Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult.

abstract：:Although social, physical, and cognitive activities have each been suggested to reduce the risk of Alzheimer's disease (AD), epidemiologic studies cannot determine which activity or combination of activities is most important. To address this question, mutant APP transgenic AD mice were reared long-term in one of four...

journal_title：Neurobiology of learning and memory

authors： Cracchiolo JR,Mori T,Nazian SJ,Tan J,Potter H,Arendash GW

更新日期：2007-10-01 00:00:00

abstract：:Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...

journal_title：Neurobiology of learning and memory

authors： Tai CT,Cassaday HJ,Feldon J,Rawlins JN

更新日期：1995-07-01 00:00:00

abstract：:Evidence is reviewed that behavioral training and neural injury can engage metaplastic processes that regulate adaptive potential. This issue is explored within a model system that examines how training affects the capacity to learn within the lower (lumbosacral) spinal cord. Response-contingent (controllable) stimula...

journal_title：Neurobiology of learning and memory

authors： Grau JW,Huang YJ

更新日期：2018-10-01 00:00:00

abstract：:Over the last decade, the interest in transcranial direct current stimulation (tDCS) has continued to increase, along with consideration of how it affects neuroplasticity mechanisms in the brain. Both human and animal studies have demonstrated numerous benefits and, although its application has increased, the neurophy...

journal_title：Neurobiology of learning and memory

authors： Stafford J,Brownlow ML,Qualley A,Jankord R

更新日期：2018-04-01 00:00:00

abstract：:The present work shows that the dorsomedial telencephalic pallium of teleost fish, proposed as homologous to the amygdala of mammals, is involved in taste aversion learning (TAL). To analyze the behavioral properties of TAL in goldfish, in Experiment 1, we used a delayed procedure similar to that employed with mammals...

journal_title：Neurobiology of learning and memory

authors： Martín I,Gómez A,Salas C,Puerto A,Rodríguez F

更新日期：2011-09-01 00:00:00

abstract：:Rats were trained to run on a staircase stopping on the 3rd, 6th, 9th, and 12th steps (correct responses). Stopping on any other step was considered an error. Acute administration of 0.5 mg/kg of arecoline 15 min before the trial improved behavior and 3.5 mg/kg of arecoline caused a reduction of correct responses. An ...

journal_title：Neurobiology of learning and memory

authors： Molinengo L,Orsetti M,Pastorello B,Scordo I,Ghi P

更新日期：1995-03-01 00:00:00

abstract：:Conditioning-specific reflex modification (CRM) of the rabbit's nictitating membrane response (NMR) involves changes in responding to an unconditioned stimulus (US) when the US is tested in the absence of the conditioned stimulus. Previous experiments have shown that CRM is a function of the type and intensity of the ...

journal_title：Neurobiology of learning and memory

authors： Schreurs BG,Smith-Bell CA

更新日期：2005-09-01 00:00:00

abstract：:The current review provides a historical perspective on the evolution of hypothesized mechanisms for senescent neurophysiology, focused on the CA1 region of the hippocampus, and the relationship of senescent neurophysiology to impaired hippocampal-dependent memory. Senescent neurophysiology involves processes linked t...

journal_title：Neurobiology of learning and memory

authors： Foster TC

更新日期：2019-10-01 00:00:00

abstract：:The present study investigated whether the selective nociceptin opioid peptide (NOP) receptor agonist, Ro64-6198, impairs acquisition of fear conditioning through glutamatergic mechanisms. Systemic administration of Ro64-6198 (0.3 and 1mg/kg) or the non-competitive NMDA receptor antagonist, MK-801 (0.03 and 0.1mg/kg) ...

journal_title：Neurobiology of learning and memory

authors： Goeldner C,Reiss D,Wichmann J,Kieffer BL,Ouagazzal AM

更新日期：2009-05-01 00:00:00

abstract：:Nitric oxide (NO) is a highly labile chemical messenger which has previously been implicated in memory processes in a variety of learning paradigms and species. However, there is only limited evidence to suggest which enzymes are acted upon by NO during the formation of memory. The present study investigates the role ...

journal_title：Neurobiology of learning and memory

authors： Edwards TM,Rickard NS,Ng KT

更新日期：2002-05-01 00:00:00

abstract：:Human studies of sleep and cognition have established thatdifferent sleep stages contribute to distinct aspects of cognitive and emotional processing. However, since the majority of these findings are based on single-night studies, it is difficult to determine whether such effects arise due to individual, between-subj...

journal_title：Neurobiology of learning and memory

authors： Lerner I,Lupkin SM,Corter JE,Peters SE,Cannella LA,Gluck MA

更新日期：2016-10-01 00:00:00

abstract：:We previously identified a set of 50 genes that were differentially transcribed in the hippocampal CA1 region of aged, learning-impaired rats compared to aged, superior learning animals during a Morris water maze paradigm. In the current study, we expressed three of these genes (Pctk1, Tcf12 and Ccnd1), which had show...

journal_title：Neurobiology of learning and memory

authors： Wu K,Li S,Bodhinathan K,Meyers C,Chen W,Campbell-Thompson M,McIntyre L,Foster TC,Muzyczka N,Kumar A

更新日期：2012-01-01 00:00:00

abstract：:Corticosterone (CORT), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion CA3. We tested the hypothesis that CORT would impair spatial memory, a hippocampal function. In each of the three experiments, rats received daily, subcutaneous injections of either CORT (26.8 mg/kg bod...

journal_title：Neurobiology of learning and memory

authors： Coburn-Litvak PS,Pothakos K,Tata DA,McCloskey DP,Anderson BJ

更新日期：2003-07-01 00:00:00

abstract：:The neurophysiological basis for context conditioning is conceptually problematic because neurophysiological descriptions of activity-dependent (associative) forms of neuronal plasticity uniformly assume that a specific temporal relationship between signals is necessary for memory induction. In the present experiments...

journal_title：Neurobiology of learning and memory

authors： Talk AC,Muzzio IA,Matzel LD

更新日期：1999-09-01 00:00:00

abstract：:The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the i...

journal_title：Neurobiology of learning and memory

authors： Shymansky T,Hughes E,Rothwell CM,Lukowiak K

更新日期：2018-03-01 00:00:00

abstract：:It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...

journal_title：Neurobiology of learning and memory

authors： Roesler R

更新日期：2017-07-01 00:00:00

abstract：:Drug addiction can be understood as a pathological subversion of normal brain learning and memory processes strengthened by the motivational impact of drug-associated stimuli, leading to the establishment of compulsive drug-seeking habits. Such habits evolve through a cascade of complex associative processes with Pavl...

journal_title：Neurobiology of learning and memory

authors： Robbins TW,Everitt BJ

更新日期：2002-11-01 00:00:00

abstract：:One of the major achievements of the last century of research in experimental psychology is the identification of a coherent set of theories and principles to characterize the nature of simple forms of associative learning. Major advances are also currently being made at a rapid pace in the neurobiology of associative...

journal_title：Neurobiology of learning and memory

authors： Delamater AR,Lattal KM

更新日期：2014-02-01 00:00:00

abstract：:Studies of both humans and animals suggest that anterior cingulate cortex (ACC) is important for processing pain perception. We identified that perigenul ACC (pACC) sensitization and enhanced visceral pain in a visceral hypersensitive rat in previous studies. Pain contains both sensory and affective dimensions. Teasin...

journal_title：Neurobiology of learning and memory

authors： Yan N,Cao B,Xu J,Hao C,Zhang X,Li Y

更新日期：2012-01-01 00:00:00

abstract：:Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in differ...

journal_title：Neurobiology of learning and memory

authors： Obiang P,Maubert E,Bardou I,Nicole O,Launay S,Bezin L,Vivien D,Agin V

更新日期：2011-09-01 00:00:00

abstract：:Human episodic memory refers to the recollection of an unique past experience in terms of what happened, and where and when it happened. Factoring out the issue of conscious recollection, episodic memory, even at the behavioral level, has been difficult to demonstrate in non-human mammals. Although, it was previously ...

journal_title：Neurobiology of learning and memory

authors： Dere E,Huston JP,De Souza Silva MA

更新日期：2005-11-01 00:00:00

abstract：:Three experiments studied the effectiveness of ketamine acting as an aversive unconditioned stimulus (UCS) in a conditioned flavor aversion procedure. In Experiment 1a, three conditioning trials where sucrose was paired with ketamine produced a weak but significant aversion to sucrose; Experiment 1b showed that this e...

journal_title：Neurobiology of learning and memory

authors： Aguado L,del Valle R,Pérez L

更新日期：1997-09-01 00:00:00

abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...

journal_title：Neurobiology of learning and memory

authors： Rohan JG,Miklasevich MK,McInturf SM,Bechmann NA,Moore RJ,Hatcher-Solis C,Jankord R

更新日期：2020-01-01 00:00:00

abstract：:Two experiments investigated the potential facilitative effects of prior instructed awareness and predetermined learning criteria on humans' ability to make transitive inference (TI) judgments. Participants were first exposed to a learning phase and required to learn five premise pairs (A+B-, B+C-, C+D-, D+E-, E+F-). ...

journal_title：Neurobiology of learning and memory

authors： Munnelly A,Dymond S

更新日期：2014-03-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:Carriers of a FMR1 premutation allele (between 55 and 199 CGG repeats) are at risk of developing a wide range of medical, psychiatric and cognitive disorders, including executive dysfunction. These cognitive deficits are often less severe for female premutation carriers compared to male premutation carriers, albeit si...

journal_title：Neurobiology of learning and memory

authors： Shelton AL,Cornish K,Fielding J

更新日期：2017-10-01 00:00:00

abstract：:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanis...

journal_title：Neurobiology of learning and memory

authors： Hughes E,Shymansky T,Sunada H,Lukowiak K

更新日期：2016-12-01 00:00:00

abstract：:Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activati...

journal_title：Neurobiology of learning and memory

authors： Metherate R,Hsieh CY

更新日期：2003-11-01 00:00:00

abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

journal_title：Neurobiology of learning and memory

authors： Quartermain D,Garcia deSoria V

更新日期：2001-07-01 00:00:00

abstract：:Adult male Wistar rats with a substantia nigra pars compacta (SNc) lesion induced by intranigral administration of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used as a model of early phase Parkinson's disease (PD). This lesion caused a partial depletion of striatal dopamine (DA). The animals w...

journal_title：Neurobiology of learning and memory

authors： Bellissimo MI,Kouzmine I,Ferro MM,de Oliveira BH,Canteras NS,Da Cunha C

更新日期：2004-09-01 00:00:00