Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.

abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

journal_title：Neurobiology of learning and memory

authors： Quartermain D,Garcia deSoria V

更新日期：2001-07-01 00:00:00

abstract：:Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...

journal_title：Neurobiology of learning and memory

authors： Wright WG,McCance EF,Carew TJ

更新日期：1996-05-01 00:00:00

abstract：:Recent evidence suggests that an interaction of noradrenaline (NE) and cortisol (CORT) during encoding leads to greater consolidation of emotional memories. Convergent models of posttraumatic stress disorder (PTSD) suggest the release of CORT and NE lead to greater intrusive memories in PTSD. This study examined the e...

journal_title：Neurobiology of learning and memory

authors： Nicholson EL,Bryant RA,Felmingham KL

更新日期：2014-07-01 00:00:00

abstract：:It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the fo...

journal_title：Neurobiology of learning and memory

authors： Havekes R,Nijholt IM,Visser AK,Eisel UL,Van der Zee EA

更新日期：2008-05-01 00:00:00

abstract：:It has been shown that the brain has its own intrinsic renin-angiotensin system (RAS) and angiotensin-(1-7) (Ang-(1-7)) is particularly interesting, because it appears to counterbalance most of the Ang II effects. Ang-(1-7) exerts its biological function through activation of the G-protein-coupled receptor Mas. Intere...

journal_title：Neurobiology of learning and memory

authors： Lazaroni TL,Raslan AC,Fontes WR,de Oliveira ML,Bader M,Alenina N,Moraes MF,Dos Santos RA,Pereira GS

更新日期：2012-01-01 00:00:00

abstract：:Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...

journal_title：Neurobiology of learning and memory

authors： Epstein HT,Child FM,Kuzirian AM,Alkon DL

更新日期：2003-03-01 00:00:00

abstract：:Studies of both humans and animals suggest that anterior cingulate cortex (ACC) is important for processing pain perception. We identified that perigenul ACC (pACC) sensitization and enhanced visceral pain in a visceral hypersensitive rat in previous studies. Pain contains both sensory and affective dimensions. Teasin...

journal_title：Neurobiology of learning and memory

authors： Yan N,Cao B,Xu J,Hao C,Zhang X,Li Y

更新日期：2012-01-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is abundantly expressed in postmitotic neurons of the developed nervous system. MAPK is activated and required for induction of long-term potentiation (LTP) in the CA1 area of the hippocampus, which is blocked by the specific inhibitor of the MAPK kinase, PD 098059. Recently it ...

journal_title：Neurobiology of learning and memory

authors： Walz R,Roesler R,Quevedo J,Sant'Anna MK,Madruga M,Rodrigues C,Gottfried C,Medina JH,Izquierdo I

更新日期：2000-01-01 00:00:00

abstract：:Memory consolidation is associated with sleep physiology but the contribution of specific sleep stages remains controversial. To clarify the contribution of REM sleep, participants were administered two REM sleep-sensitive tasks to determine if associated changes occurred only in REM sleep. Twenty-two participants (7 ...

journal_title：Neurobiology of learning and memory

authors： Nielsen T,O'Reilly C,Carr M,Dumel G,Godin I,Solomonova E,Lara-Carrasco J,Blanchette-Carrière C,Paquette T

更新日期：2015-07-01 00:00:00

abstract：:Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in th...

journal_title：Neurobiology of learning and memory

authors： Kinney JW,Sanchez-Alavez M,Barr AM,Criado JR,Crawley JN,Behrens MM,Henriksen SJ,Bartfai T

更新日期：2009-10-01 00:00:00

abstract：:Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in differ...

journal_title：Neurobiology of learning and memory

authors： Obiang P,Maubert E,Bardou I,Nicole O,Launay S,Bezin L,Vivien D,Agin V

更新日期：2011-09-01 00:00:00

abstract：:Trace eyeblink conditioning requires animals to associate a neutral stimulus (CS) and an aversive periorbital shock (US) that occurred moment later. Acquisition in this conditioning depends on several forebrain regions including the hippocampus, medial prefrontal, and entorhinal cortices in addition to the cerebellum....

journal_title：Neurobiology of learning and memory

authors： Shearkhani O,Takehara-Nishiuchi K

更新日期：2013-02-01 00:00:00

abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...

journal_title：Neurobiology of learning and memory

authors： Chatburn A,Lushington K,Kohler MJ

更新日期：2021-01-15 00:00:00

abstract：:There is extensive evidence that post-training administration of the adrenocortical hormone corticosterone facilitates memory consolidation processes in a variety of contextual and spatial-dependent learning situations. The present experiments examine whether corticosterone can modulate memory of auditory-cue classica...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Figueroa IR,Poytress BS,Roozendaal B,McGaugh JL,Weinberger NM

更新日期：2004-01-01 00:00:00

abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...

journal_title：Neurobiology of learning and memory

authors： Beggiato S,Borelli AC,Tomasini MC,Morgano L,Antonelli T,Tanganelli S,Cuomo V,Ferraro L

更新日期：2017-03-01 00:00:00

abstract：:Molecular genetic manipulation of the mouse offers the possibility of elucidating the function of individual gene products in neural systems underlying learning and memory. Many extant learning paradigms for mice rely on negative reinforcement, involve simple problems that are relatively rapidly acquired and thus prec...

journal_title：Neurobiology of learning and memory

authors： Brooks AI,Cory-Slechta DA,Murg SL,Federoff HJ

更新日期：2000-11-01 00:00:00

abstract：:The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine ar...

journal_title：Neurobiology of learning and memory

authors： Soares JC,Fornari RV,Oliveira MG

更新日期：2006-09-01 00:00:00

abstract：:In insects, cholinergic neurons are thought to transmit olfactory conditioned stimulus (CS) to the sites for associating the CS with unconditioned stimulus (US), but the types of acetylcholine (ACh) receptor used by neurons participating in the association have not been determined. In cockroaches, a type of nicotinic ...

journal_title：Neurobiology of learning and memory

authors： Watanabe H,Matsumoto CS,Nishino H,Mizunami M

更新日期：2011-01-01 00:00:00

abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

journal_title：Neurobiology of learning and memory

authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

更新日期：2016-01-01 00:00:00

abstract：:Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp ...

journal_title：Neurobiology of learning and memory

authors： Camus S,Ko WK,Pioli E,Bezard E

更新日期：2015-10-01 00:00:00

abstract：:Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...

journal_title：Neurobiology of learning and memory

authors： Buttigieg A,Flores O,Hernández A,Sáez-Briones P,Burgos H,Morgan C

更新日期：2014-01-01 00:00:00

abstract：:Formation of long-term memories requires coordinated gene expression, which can be regulated at transcriptional, post-transcriptional, and translational levels. Post-transcriptional stabilization and destabilization of mRNAs provides precise temporal and spatial regulation of gene expression, which is critical for con...

journal_title：Neurobiology of learning and memory

authors： Lee YS,Lee JA,Kaang BK

更新日期：2015-10-01 00:00:00

abstract：:Carriers of a FMR1 premutation allele (between 55 and 199 CGG repeats) are at risk of developing a wide range of medical, psychiatric and cognitive disorders, including executive dysfunction. These cognitive deficits are often less severe for female premutation carriers compared to male premutation carriers, albeit si...

journal_title：Neurobiology of learning and memory

authors： Shelton AL,Cornish K,Fielding J

更新日期：2017-10-01 00:00:00

abstract：:Spatial orientation is a cognitive ability that is indispensable for survival. Several visual distal cues present in the context can be integrated, establishing a cognitive map. Although there is cumulative evidence about the neural substrate involved in spatial memory acquisition, the brain networks mediating the pro...

journal_title：Neurobiology of learning and memory

authors： Zorzo C,Arias JL,Méndez M

更新日期：2020-11-01 00:00:00

abstract：:Human drug addiction is a complex disorder, in which exogenous substances are able to recruit and maintain behaviors involved in drug taking. Many drugs that are addictive in humans are able to act on natural brain systems for learning and memory, and while many memory systems may be affected by addictive drugs, work ...

journal_title：Neurobiology of learning and memory

authors： Schmitzer-Torbert N,Apostolidis S,Amoa R,O'Rear C,Kaster M,Stowers J,Ritz R

更新日期：2015-02-01 00:00:00

abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...

journal_title：Neurobiology of learning and memory

authors： Turner LF,Liu Z,Bures J

更新日期：1997-07-01 00:00:00

abstract：:Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a neutral cue to predict a biologically relevant event: after repeated predictive pairings, Pavlov's dogs were conditioned to anticipate food at the sound of a bell, which caused them to salivate. Like sustenance, danger is biologically releva...

journal_title：Neurobiology of learning and memory

authors： VanElzakker MB,Dahlgren MK,Davis FC,Dubois S,Shin LM

更新日期：2014-09-01 00:00:00

abstract：:In spite of evidence about negative effects of Nandrolone Decanoate (ND) on cognitive and memory performance, the underlying mechanisms are complex and have remained unclear. This research examines the role of Calcineurin in synaptic plasticity and memory storage impairment in ND administrated adolescent male rats. Fo...

journal_title：Neurobiology of learning and memory

authors： Moradpour F,Moazedi AA,Pourmotabbed A,Zarei F

更新日期：2019-09-01 00:00:00

abstract：:Rats were trained to run on a staircase stopping on the 3rd, 6th, 9th, and 12th steps (correct responses). Stopping on any other step was considered an error. Acute administration of 0.5 mg/kg of arecoline 15 min before the trial improved behavior and 3.5 mg/kg of arecoline caused a reduction of correct responses. An ...

journal_title：Neurobiology of learning and memory

authors： Molinengo L,Orsetti M,Pastorello B,Scordo I,Ghi P

更新日期：1995-03-01 00:00:00

abstract：:Electrolytic lesions centered on the amygdaloid central nucleus (ACe) resulted in the inability of rats to acquire a Pavlovian conditional vocalization response. Conditioning consisted of pairing a light conditional stimulus with a tailshock unconditional stimulus (US). The thresholds of three unconditional responses ...

journal_title：Neurobiology of learning and memory

authors： Borszcz GS,Leaton RN

更新日期：2003-05-01 00:00:00