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Impairment of memory consolidation by galanin correlates with in vivo inhibition of both LTP and CREB phosphorylation.

Abstract：

:Changes in the state of CREB phosphorylation and in LTP in the hippocampus have been associated with learning and memory. Here we show that galanin, the neuropeptide released in the hippocampal formation from cholinergic and noradrenergic fibers, that has been shown to produce impairments in memory consolidation in the Morris water maze task inhibits both LTP and CREB phosphorylation in the rat hippocampus in vivo. While there are many transmitters regulating CREB phosphorylation none has been shown to suppress behaviorally-induced hippocampal CREB phosphorylation as potently as galanin. The in vivo inhibition of dentate gyrus-LTP and of CREB phosphorylation by the agonist occupancy of GalR1 and GalR2-type galanin receptors provides strong in vivo cellular and molecular correlates to galanin-induced learning deficits and designates galanin as a major regulator of the memory consolidation process.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Kinney JW,Sanchez-Alavez M,Barr AM,Criado JR,Crawley JN,Behrens MM,Henriksen SJ,Bartfai T

doi

10.1016/j.nlm.2009.06.005

subject

Has Abstract

pub_date

2009-10-01 00:00:00

pages

429-38

issue

3

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(09)00128-2

journal_volume

92

pub_type

杂志文章

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