Abstract：
:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippocampal ERK participation in LTM reconsolidation and persistence using an inhibitory avoidance task (IA) at different time points. Intra-dorsal-hippocampal (dHIP) administration of an ERK inhibitor (PD098059, PD, 1.0μg/hippocampus) 3h after retrieval did not affect reconsolidation of a strong IA, when tested 24h apart. However, the same manipulation impaired performance when animals were tested at 7d, regardless of the training's strength; and being specific to memory reactivation. To the best of our knowledge, this is the first report showing that persistence might be triggered after memory reactivation involving an ERK/MAPK-dependent process.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Krawczyk MC,Navarro N,Blake MG,Romano A,Feld M,Boccia MMdoi
10.1016/j.nlm.2016.06.013subject
Has Abstractpub_date
2016-09-01 00:00:00pages
79-88eissn
1074-7427issn
1095-9564pii
S1074-7427(16)30088-0journal_volume
133pub_type
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