Abstract：
:The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng). The lesion reduced ChAT activity in the frontal and parietal cortices, hippocampus, and olfactory bulbs. The lesion did not significantly alter Na+/K(+)-ATPase activity in cortex, hippocampus, or olfactory bulbs, or endogenous levels of neuropeptide Y and neurokinin B within the BF. The BF lesions impaired both stimulus discriminability and response bias in young and old rats. The BF lesions had a significantly greater effect upon stimulus discriminability and response bias in aged rats, compared to young rats, only when the stimulus duration was very brief, i.e., when the task was most difficult to solve. At longer stimulus durations, aging and lesions showed no interaction. The results suggest that the selective loss of cholinergic cells in the BF, but not normal aging, impairs the ability to discriminate between independent sensory stimuli. The loss of these cells confers a response bias in simple operant tasks involving motor responses to reward-related visual stimuli.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Stoehr JD,Mobley SL,Roice D,Brooks R,Baker LM,Wiley RG,Wenk GLdoi
10.1006/nlme.1997.3768subject
Has Abstractpub_date
1997-05-01 00:00:00pages
214-27issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(97)93768-0journal_volume
67pub_type
杂志文章abstract：:Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, t...
journal_title：Neurobiology of learning and memory
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,meta分析,评审
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