Abstract:
:The hypotheses that the medial septal area (MSA) is critical for working memory and that MSA neural activity is positively regulated by cholinergic inputs leads to two testable predictions: (1) working memory can be bidirectionally modulated by muscarinic manipulations of the MSA and (2) muscarinic activation of the MSA can enhance memory under conditions of mnemonic impairment. Memory was assessed by T-maze spatial alternation following intraseptal infusion of muscarinic drugs in rats pretreated with intraperitoneal (IP-) injections of scopolamine. Scopolamine dose-dependently impaired working memory and shifted the hippocampal theta activity to a higher peak frequency. Intraseptal scopolamine mimicked the behavioral effects of IP-scopolamine, and intraseptal carbachol appeared to reverse both the behavioral and physiological effects of IP-scopolamine. The results indicate that the amnestic effect of antimuscarinic drugs may be due to an interaction in the MSA and that conditions of memory impairment may be alleviated by selective muscarinic activation of the MSA.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Givens B,Olton DSdoi
10.1006/nlme.1995.1031subject
Has Abstractpub_date
1995-05-01 00:00:00pages
269-76issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(85)71031-3journal_volume
63pub_type
临床试验,杂志文章,随机对照试验abstract::An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regu...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2013.07.014
更新日期:2014-02-01 00:00:00
abstract::Memories for daily events require that individuals integrate initial fragile traces of events over time. Recent evidence suggests that reward anticipation enhances memory performance and amplifies frontal theta activity for remembered items vs. forgotten items. However, little is known about how incidental rewards aft...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2019.01.008
更新日期:2019-02-01 00:00:00
abstract::Expression of immediate-early genes, like Egr-1, has been shown to be induced by activity-dependent synaptic plasticity or behavioral training and is widely thought to play an important role in long-term memory (LTM) formation. However, little is known about the role of Egr-1 in the maintenance of memory storage. Here...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2012.08.001
更新日期:2012-10-01 00:00:00
abstract::Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.07.001
更新日期:2016-11-01 00:00:00
abstract::Early life adverse events can lead to structural and functional impairments in the prefrontal cortex (PFC). Here, we investigated whether maternal deprivation (MD) alters PFC-dependent executive functions, neurons and astrocytes number and synaptic plasticity in adult male Long-Evans rats. The deprivation protocol con...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2012.08.004
更新日期:2012-10-01 00:00:00
abstract::The pond snail Lymnaea stagnalis is capable of learning taste aversion by pairing presentations of a sucrose solution and an electric shock and consolidating it into long-term memory (LTM), which is referred to as conditioned taste aversion (CTA). We asked here if the neurotransmitter octopamine is involved in CTA. We...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2017.04.010
更新日期:2017-05-01 00:00:00
abstract::The unique polarity of neurons requires that synaptic inputs are relayed to the nucleus to trigger changes in gene expression. This long distance signaling process is crucial for the function and survival of neuronal circuits. To that end, neurons have developed multiple modes of signal transmission from the synapse t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2016.07.024
更新日期:2017-02-01 00:00:00
abstract::The purpose of this study was to explore the effects of slow-wave disruption on positive and negative word recognition in a sample of healthy control participants and those with major depressive disorder. Prior to sleep, participants learned a set of emotional and neutral words during an encoding task by responding wh...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2015.09.006
更新日期:2015-11-01 00:00:00
abstract::Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2020.107355
更新日期:2021-01-01 00:00:00
abstract::Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as 'incubation of craving'. As adolescence...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.09.002
更新日期:2017-09-01 00:00:00
abstract::Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippoca...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.11.003
更新日期:2016-12-01 00:00:00
abstract::Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...
journal_title:Neurobiology of learning and memory
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.nlm.2004.09.001
更新日期:2005-03-01 00:00:00
abstract::Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2011.04.002
更新日期:2011-07-01 00:00:00
abstract::Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2015.11.020
更新日期:2016-01-01 00:00:00
abstract::Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a neutral cue to predict a biologically relevant event: after repeated predictive pairings, Pavlov's dogs were conditioned to anticipate food at the sound of a bell, which caused them to salivate. Like sustenance, danger is biologically releva...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2013.11.014
更新日期:2014-09-01 00:00:00
abstract::Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form of discrepancies between actual and expected reward outcomes. Additionally, in learn...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2014.07.010
更新日期:2015-01-01 00:00:00
abstract::The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine ar...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2006.02.006
更新日期:2006-09-01 00:00:00
abstract::Temporal lobe epilepsy patients have demonstrated a relative preservation in the integrity of implicit memory procedures. We examined performance in a verbal implicit and explicit memory task in left anterior temporal lobectomy patients (LATL) and healthy normal controls (NCs) while undergoing fMRI. We hypothesized th...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2012.08.005
更新日期:2012-10-01 00:00:00
abstract::In order to study the effects of differential housing conditions on recovery from damage to different components of the hippocampal formation, 85 rats received bilateral lesions of the hippocampus, entorhinal cortex, or subiculum or sham surgery and then were housed for 30 days in either an enriched environment or an ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.3745
更新日期:1997-01-01 00:00:00
abstract::Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pai...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/s1074-7427(03)00057-1
更新日期:2003-09-01 00:00:00
abstract::Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2013.10.018
更新日期:2014-01-01 00:00:00
abstract::There is extensive evidence that post-training administration of the adrenocortical hormone corticosterone facilitates memory consolidation processes in a variety of contextual and spatial-dependent learning situations. The present experiments examine whether corticosterone can modulate memory of auditory-cue classica...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2003.09.002
更新日期:2004-01-01 00:00:00
abstract::The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2008.07.013
更新日期:2008-11-01 00:00:00
abstract::Chronic stress leads to a dysregulated inhibitory tone that could impact hippocampal-dependent spatial learning and memory. The present study examined whether spatial memory deficits resulting from chronic stress could be overcome by antagonizing the GABAA receptor, a prominent inhibitory receptor of GABA in the hippo...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2017.09.002
更新日期:2017-11-01 00:00:00
abstract::The activation of cAMP response element-binding protein (CREB) after a learning experience is a common feature in the formation of several associative memories. We recently demonstrated that the increase in the hippocampal phosphorylated CREB (pCREB) levels 1 h after a short exploration of an open field (OF) was assoc...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2005.12.002
更新日期:2006-07-01 00:00:00
abstract::Most models of human and animal learning assume that learning is proportional to the discrepancy between a delivered outcome and the outcome predicted by all cues present during that trial (i.e., total error across a stimulus compound). This total error reduction (TER) view has been implemented in connectionist and ar...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2013.07.018
更新日期:2014-02-01 00:00:00
abstract::Brief physical exercise enhances memories for neutral events, and recently has been shown to modulate fear learning in animals. To date there is no evidence pertaining to the impact of exercise on emotional memories in humans. Accordingly, this study investigated the role of brief exercise in the development of emotio...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.nlm.2017.03.012
更新日期:2017-05-01 00:00:00
abstract::Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1042
更新日期:1995-07-01 00:00:00
abstract::Intellectual disability is a common feature in genetic disorders with enhanced RAS-ERK1/2 signaling, including neurofibromatosis type 1 (NF1) and Noonan syndrome (NS). Additional training trials and additional spacing between trials, respectively, restores memory deficits in animal models of NF1 and NS. However, the r...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2020.107233
更新日期:2020-07-01 00:00:00
abstract::Research on how steroid hormones mediate mnemonic processes have focused on effects of 17beta-estradiol (E(2)); yet, progesterone (P(4)) co-varies with E(2) across endogenous hormonal milieu, and itself may influence cognitive processes. We investigated the hypothesis that acute P(4) treatment enhances cognitive perfo...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2008.03.005
更新日期:2008-07-01 00:00:00