Abstract：
:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in different combinations were recently developed. The validity of these mouse models of AD from a behavioral viewpoint, however, has not been extensively evaluated. Thus, using an automated behavior monitoring system, we analyzed various behavioral domains, including executive function, and learning and memory. The App-KI mice carrying NL-G-F mutations showed clear deficits in spatial memory and flexible learning, enhanced compulsive behavior, and reduced attention performance. Mice carrying NL-F mutations exhibited modest abnormalities. The NL-G-F mice had a greater and more rapid accumulation of Aβ deposits and glial responses. These findings reveal that single pathologic App-KI is sufficient to produce deficits in broad cognitive domains and that App-KI mouse lines with different levels of pathophysiology are useful models of AD.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara Sdoi
10.1016/j.nlm.2016.07.001subject
Has Abstractpub_date
2016-11-01 00:00:00pages
73-82eissn
1074-7427issn
1095-9564pii
S1074-7427(16)30101-0journal_volume
135pub_type
杂志文章abstract：:Phosphodiesterase inhibitors (PDE-Is) enhance cAMP and/or cGMP signaling via reducing the degradation of these cyclic nucleotides. Both cAMP and cGMP signaling are essential for a variety of cellular functions and exert their effects both pre- and post-synaptically. Either of these second messengers relays and amplifi...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
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abstract：:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...
journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2010.11.012
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abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2014.11.002
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2003.09.002
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2017.07.002
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.08.005
更新日期：2012-10-01 00:00:00
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journal_title：Neurobiology of learning and memory
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doi：10.1006/nlme.1999.3913
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.2000.3990
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2011.06.003
更新日期：2011-09-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.03.005
更新日期：2007-07-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.2000.3975
更新日期：2001-03-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2006.05.002
更新日期：2006-11-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1996.0031
更新日期：1996-05-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2005.07.002
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.12.004
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journal_title：Neurobiology of learning and memory
pub_type： 临床试验,杂志文章
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更新日期：2005-07-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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更新日期：2011-01-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2016.06.005
更新日期：2016-09-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.01.002
更新日期：2008-07-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
abstract：:Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.01.004
更新日期：2018-03-01 00:00:00
abstract：:This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.10.008
更新日期：2009-03-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
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更新日期：2013-11-01 00:00:00
abstract：:Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2005.03.002
更新日期：2005-07-01 00:00:00
