当前位置： SCI文献检索 > NEUROBIOLOGY OF LEARNING AND MEMORY期刊下所有文献 > Integrated memory for objects, places, and temporal order: evidence for episodic-like memory in mice.

Integrated memory for objects, places, and temporal order: evidence for episodic-like memory in mice.

Abstract：

:Human episodic memory refers to the recollection of an unique past experience in terms of what happened, and where and when it happened. Factoring out the issue of conscious recollection, episodic memory, even at the behavioral level, has been difficult to demonstrate in non-human mammals. Although, it was previously shown that rodents can associate what and when or what and where information given on unique trials, it proved to be difficult to demonstrate memory for what, where, and when simultaneously in mammals, without using extensive training procedures, which might induce semantic rather than episodic memory recall. Towards the goal of an animal model of human episodic memory we designed an three-trial object exploration task in which different versions of the novelty-preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored, and (c) the temporal order memory for object presented at distinct time points. We found that mice spent more time exploring two "old familiar" objects relative to two "recent familiar" objects, reflecting memory for what and when and concomitantly directed more exploration at a spatially displaced "old familiar" object relative to a stationary "old familiar" object, reflecting memory for what and where. These results suggest that during a single test trial the mice were able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered, and (c) to discriminate the relative recency in which different objects were presented. According to the currently discussed behavioral criteria for episodic-like memory in animals, our results suggest that mice are capable to form such higher order memories.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Dere E,Huston JP,De Souza Silva MA

doi

10.1016/j.nlm.2005.07.002

keywords:

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

214-21

issue

3

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(05)00057-2

journal_volume

84

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF LEARNING AND MEMORY文献大全
  • The perisylvian language network and language analytical abilities.

    abstract：:Aiming at exploring the brain's structural organisation underlying successful second language learning, we investigate the anatomy of the perisylvian language network in a group of healthy adults, consisting of participants with high and average language analytical abilities. Utilising deterministic tractography, six ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.07.003

    authors： Kepinska O,Lakke EAJF,Dutton EM,Caspers J,Schiller NO

    更新日期：2017-10-01 00:00:00

  • Effects of oral cortisol treatment in healthy young women on memory retrieval of negative and neutral words.

    abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

    journal_title：Neurobiology of learning and memory

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.nlm.2004.09.001

    authors： Kuhlmann S,Kirschbaum C,Wolf OT

    更新日期：2005-03-01 00:00:00

  • Experience with songs in adulthood reduces song-induced gene expression in songbird auditory forebrain.

    abstract：:Male songbirds learn to produce song within a limited phase early in life; however they continue to learn to recognize songs in adulthood. Studies looking at Zenk activation after exposure to songs learned early in life for song production and songs learned in adulthood show opposite patterns of activation, suggesting...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.05.002

    authors： McKenzie TL,Hernandez AM,MacDougall-Shackleton SA

    更新日期：2006-11-01 00:00:00

  • Agmatine facilitates memory of an inhibitory avoidance task in adult rats.

    abstract：:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after traini...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2002.4076

    authors： Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CA

    更新日期：2002-09-01 00:00:00

  • Systemic administrations of β-estradiol alleviate both conditioned and sensitized fear responses in an ovariectomized rat model of post-traumatic stress disorder.

    abstract：:Although no single widely accepted animal model of PTSD has been established to date, the single prolonged stress (SPS) animal model has been partially validated as a model for PTSD. SPS rats mimic the pathophysiological abnormalities and behavioral characteristics of PTSD, such as enhanced fear response to the trauma...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2013.02.003

    authors： Mirshekar M,Abrari K,Goudarzi I,Rashidy-Pour A

    更新日期：2013-05-01 00:00:00

  • The study of associative learning: mapping from psychological to neural levels of analysis.

    abstract：:One of the major achievements of the last century of research in experimental psychology is the identification of a coherent set of theories and principles to characterize the nature of simple forms of associative learning. Major advances are also currently being made at a rapid pace in the neurobiology of associative...

    journal_title：Neurobiology of learning and memory

    pub_type： 社论

    doi：10.1016/j.nlm.2013.12.006

    authors： Delamater AR,Lattal KM

    更新日期：2014-02-01 00:00:00

  • Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder.

    abstract：:Recent evidence suggests that an interaction of noradrenaline (NE) and cortisol (CORT) during encoding leads to greater consolidation of emotional memories. Convergent models of posttraumatic stress disorder (PTSD) suggest the release of CORT and NE lead to greater intrusive memories in PTSD. This study examined the e...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2013.11.018

    authors： Nicholson EL,Bryant RA,Felmingham KL

    更新日期：2014-07-01 00:00:00

  • Developmental emergence of long-term memory for sensitization in Aplysia.

    abstract：:Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0031

    authors： Wright WG,McCance EF,Carew TJ

    更新日期：1996-05-01 00:00:00

  • 2D:4D and spatial abilities: From rats to humans.

    abstract：:Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and waterm...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.04.012

    authors： Müller N,Campbell S,Nonaka M,Rost TM,Pipa G,Konrad BN,Steiger A,Czisch M,Fernández G,Dresler M,Genzel L

    更新日期：2018-05-01 00:00:00

  • ORAI1-dependent synaptic plasticity in rat hippocampal neurons.

    abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.12.024

    authors： Tshuva RY,Korkotian E,Segal M

    更新日期：2017-04-01 00:00:00

  • Enhanced cognitive activity--over and above social or physical activity--is required to protect Alzheimer's mice against cognitive impairment, reduce Abeta deposition, and increase synaptic immunoreactivity.

    abstract：:Although social, physical, and cognitive activities have each been suggested to reduce the risk of Alzheimer's disease (AD), epidemiologic studies cannot determine which activity or combination of activities is most important. To address this question, mutant APP transgenic AD mice were reared long-term in one of four...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.07.007

    authors： Cracchiolo JR,Mori T,Nazian SJ,Tan J,Potter H,Arendash GW

    更新日期：2007-10-01 00:00:00

  • Ethanol-seeking behavior is expressed directly through an extended amygdala to midbrain neural circuit.

    abstract：:Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.11.013

    authors： Pina MM,Cunningham CL

    更新日期：2017-01-01 00:00:00

  • Relational memory generalization and integration in a transitive inference task with and without instructed awareness.

    abstract：:Two experiments investigated the potential facilitative effects of prior instructed awareness and predetermined learning criteria on humans' ability to make transitive inference (TI) judgments. Participants were first exposed to a learning phase and required to learn five premise pairs (A+B-, B+C-, C+D-, D+E-, E+F-). ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.01.004

    authors： Munnelly A,Dymond S

    更新日期：2014-03-01 00:00:00

  • Psychophysiological arousal at encoding leads to reduced reactivity but enhanced emotional memory following sleep.

    abstract：:While sleep's role in emotional memory processing is gaining increasing support, its effect on emotion regulation remains equivocal. Moreover, little is known about the link between emotional reactivity at the time of encoding and subsequent sleep-based emotional memory consolidation. This study examined whether sleep...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.06.002

    authors： Cunningham TJ,Crowell CR,Alger SE,Kensinger EA,Villano MA,Mattingly SM,Payne JD

    更新日期：2014-10-01 00:00:00

  • Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology.

    abstract：:We previously identified a set of 50 genes that were differentially transcribed in the hippocampal CA1 region of aged, learning-impaired rats compared to aged, superior learning animals during a Morris water maze paradigm. In the current study, we expressed three of these genes (Pctk1, Tcf12 and Ccnd1), which had show...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2011.09.006

    authors： Wu K,Li S,Bodhinathan K,Meyers C,Chen W,Campbell-Thompson M,McIntyre L,Foster TC,Muzyczka N,Kumar A

    更新日期：2012-01-01 00:00:00

  • Loss of MsrB1 perturbs spatial learning and long-term potentiation/long-term depression in mice.

    abstract：:MsrB1 belongs to the methionine sulfoxide reductase family, it is also known as selenoprotein R for the sake of possessing a selenocysteine residue. It has been reported that MsrB1 could interact with actin, TRPM6, clusterin, and amyloid-beta in vitro. Thus, we presumed that MsrB1 may play an important role in central...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.107104

    authors： Shi T,Yang Y,Zhang Z,Zhang L,Song J,Ping Y,Du X,Song G,Liu Q,Li N

    更新日期：2019-12-01 00:00:00

  • Scopolamine does not impact declarative and motor memory consolidation across a night of sleep or a day of wakefulness.

    abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.08.017

    authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

    更新日期：2018-11-01 00:00:00

  • Effects of intrastriatal injections of platelet-activating factor and the PAF antagonist BN 52021 on memory.

    abstract：:The present experiments examined the effects of posttraining intra-dorsal striatal (i.e., caudate-putamen) injections of the phospholipid methylcarbamyl platelet-activating factor (mc-PAF) and the platelet-activating factor (PAF) antagonist BN 52021 on memory using a striatal-dependent cued water maze task. Male Long-...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0058

    authors： Packard MG,Teather LA,Bazan NG

    更新日期：1996-09-01 00:00:00

  • Acute psychophysiological stress impairs human associative learning.

    abstract：:Addiction is increasingly discussed asa disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions t...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.09.003

    authors： Ehlers MR,Todd RM

    更新日期：2017-11-01 00:00:00

  • Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.

    abstract：:In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague-Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.05.001

    authors： Hunt PS,Barnet RC,Shea ME,Baker EM

    更新日期：2006-11-01 00:00:00

  • Significant life events and the shape of memories to come: a hypothesis.

    abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2005.09.004

    authors： Shors TJ

    更新日期：2006-03-01 00:00:00

  • The effects of calcium channel antagonists on short- and long-term retention in mice using spontaneous alternation behavior.

    abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2000.3981

    authors： Quartermain D,Garcia deSoria V

    更新日期：2001-07-01 00:00:00

  • "Despair" induced by extinction trials in the water maze: relationship with measures of anxiety in aged and adult rats.

    abstract：:We have previously reported that extinction of escape behavior in the water maze due to the removal of the platform coincided with the development of behavioral "despair" in aged and adult rats, as assessed by immobility. The present study examines further predictions derived from the hypothesis that the withholding o...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.09.006

    authors： Schulz D,Huston JP,Buddenberg T,Topic B

    更新日期：2007-03-01 00:00:00

  • Effects of unilateral entorhinal cortex lesion on retention of water maze performance.

    abstract：:In a previous study, adult male Sprague-Dawley rats with unilateral, electrolytic entorhinal cortex lesions showed significant deficits in acquisition of a water maze task that measured working memory. The 10 days of testing used two trials per day with an intertrial interval of 1 h, and the rats with entorhinal damag...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1998.3832

    authors： Glasier MM,Janis LS,Roof RL,Stein DG

    更新日期：1999-01-01 00:00:00

  • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease.

    abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2011.04.002

    authors： Stilling RM,Fischer A

    更新日期：2011-07-01 00:00:00

  • Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway.

    abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2015.11.020

    authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

    更新日期：2016-01-01 00:00:00

  • Polarity and subfield specific effects of transcranial direct current stimulation on hippocampal plasticity.

    abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.107126

    authors： Rohan JG,Miklasevich MK,McInturf SM,Bechmann NA,Moore RJ,Hatcher-Solis C,Jankord R

    更新日期：2020-01-01 00:00:00

  • The neural basis of individual differences in memory performance in young and older adults: Using the encoding/retrieval flip account as framework.

    abstract：:Aging is associated with cognitive decline, specifically in episodic memory. However, there are large individual differences in the extent of this decline and previous research suggests that these are associated with differences in executive functioning (EF). These EF differences, and associated differences in the enc...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2020.107251

    authors： Fu L,Maes JHR,Kessels RPC,Huijbers W

    更新日期：2020-09-01 00:00:00

  • Neonatal tactile stimulation enhances spatial working memory, prefrontal long-term potentiation, and D1 receptor activation in adult rats.

    abstract：:Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counterac...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.10.010

    authors： Zhang M,Cai JX

    更新日期：2008-05-01 00:00:00

  • Altered protein synthesis is a trigger for long-term memory formation.

    abstract：:There is ongoing debate concerning whether new protein synthesis is necessary for, or even contributes to, memory formation and storage. This review summarizes a contemporary model proposing a role for altered protein synthesis in memory formation and its subsequent stabilization. One defining aspect of the model is t...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2007.08.009

    authors： Klann E,Sweatt JD

    更新日期：2008-03-01 00:00:00