Developmental emergence of long-term memory for sensitization in Aplysia.

Abstract:

:Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we examined the development of long-term memory for sensitization. Long-term sensitization of the siphon withdrawal reflex was quantified as an increase in mean response duration observed 20-24 h after receiving a training regime of one or more 90-min sessions of electrical shock to the tail. In the first three experiments we assessed the capacity for long-term sensitization in adults and in juveniles of stages late 12 and early 12. Animals in all three age classes showed long-term sensitization. In a fourth experiment we simultaneously trained and tested both early stage 12 animals and stage 11 animals with identical stimulus parameters that were scaled down to a level appropriate to the smaller stage 11 animals. Under these conditions, the early stage 12 animals demonstrated long-term sensitization, while the stage 11 animals still showed no evidence of long-term sensitization. These results indicate that long-term sensitization first emerges at early stage 12, which is the same developmental stage in which short-term sensitization first emerges. Although these behavioral data do not elucidate underlying mechanisms, the fact that short-term and long-term memory emerge according to the same developmental timetable is consistent with the possibility that these two forms of memory may share at least some common mechanistic features.

journal_name

Neurobiol Learn Mem

authors

Wright WG,McCance EF,Carew TJ

doi

10.1006/nlme.1996.0031

subject

Has Abstract

pub_date

1996-05-01 00:00:00

pages

261-8

issue

3

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(96)90031-3

journal_volume

65

pub_type

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