Abstract：
:Activation of N-methyl-d-aspartate (NMDA) receptors has been hypothesized to mediate certain forms of learning and memory. This hypothesis is based on the ability of competitive and uncompetitive NMDA receptor antagonists to disrupt learning. We investigated the effects of glycine site antagonists and partial agonists on deficits of acquisition (learning) and consolidation (memory) in a single trial inhibitory avoidance learning paradigm. Posttraining administration of either hypoxia (exposure to 7% oxygen) or the convulsant drug pentylenetetrazole (PTZ) (45 mg/kg) to mice impaired consolidation without producing neuronal cell death. Pretreatment with the competitive glycine antagonist 7-chlorokynurenic acid (7KYN) and the glycine partial agonists 1-aminocyclopropanecarboxylic acid (ACPC) and (+)HA-966 prevented memory deficits induced by hypoxia and PTZ, but did not affect scopolamine-induced learning impairment. In addition, ACPC prevented consolidation deficits evoked by a nonexcitotoxic concentration of l-trans-pyrrolidine-2, 4-dicarboxylate, a competitive inhibitor of glutamate transport that increases extracellular levels of glutamate. Moreover, (+)HA-966, 7KYN, and ACPC facilitated both acquisition and consolidation of inhibitory avoidance training, an effect that was dose-dependent and reversed by glycine. These results indicate that memory deficits induced by both hypoxia and PTZ involve NMDA receptor activation. Furthermore, the present findings demonstrate that glycine site antagonists and partial agonists prevent memory deficits of inhibitory avoidance learning by affecting consolidation, but not acquisition processes.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Viu E,Zapata A,Capdevila J,Skolnick P,Trullas Rdoi
10.1006/nlme.1999.3947keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
146-60issue
2eissn
1074-7427issn
1095-9564pii
S1074-7427(99)93947-3journal_volume
74pub_type
杂志文章abstract：:The cholinergic system has consistently been implicated in Pavlovian fear conditioning. Considerable work has been done to localize specific nicotinic receptor subtypes in the hippocampus and determine their functional importance; however, the specific function of many of these subtypes has yet to be determined. An al...
journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.03.005
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.05.010
更新日期：2016-09-01 00:00:00
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2016.06.005
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
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doi：10.1006/nlme.1998.3866
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
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journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
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journal_title：Neurobiology of learning and memory
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