Abstract:
:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after training or 1 h before testing. Posttraining injection of agmatine facilitated (p < 0.05) memory consolidation in this task; however pretest treatment showed no effect on retrieval (p > 0.05). We suggest that the facilitatory effect of agmatine on memory consolidation in inhibitory avoidance task might be mediated through the activation of the locus coeruleus.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CAdoi
10.1006/nlme.2002.4076keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
465-9issue
2eissn
1074-7427issn
1095-9564pii
S1074742702940761journal_volume
78pub_type
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