Abstract:
:Animals tend to repeat actions that are associated with reward delivery, whereas they tend to shift responses to alternate choices following reward omission. These so-called win-stay and lose-shift responses are employed by a wide range of animals in a variety of decision-making scenarios, and depend on dissociated regions of the striatum. Specifically, lose-shift responding is impaired by extensive excitotoxic lesions of the lateral striatum. Here we used focal lesions to assess whether dorsal and ventral regions of the lateral striatum contribute differently to this effect. We found that damage to ventrolateral striatum reduced lose-shift responding without impairing win-stay, motoric, or motivational aspects of behaviour in the task, whereas lesions confined to the dorsolateral striatum significantly impaired the ability of rats to complete trials of the task. Moreover, lesions to the dorsomedial striatum had no effect on either lose-shift or win-stay responding. Together, these data suggest a novel role of the ventral portion of the lateral striatum in driving lose-shift decisions.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Thapa R,Gruber AJdoi
10.1016/j.nlm.2018.08.022subject
Has Abstractpub_date
2018-11-01 00:00:00pages
446-451eissn
1074-7427issn
1095-9564pii
S1074-7427(18)30220-Xjournal_volume
155pub_type
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