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Microinfusions of flumazenil into the basolateral but not the central nucleus of the amygdala enhance memory consolidation in rats.

Abstract：

:Extensive evidence indicates that benzodiazepine receptors in the amygdala are involved in regulating memory consolidation. Recent findings indicate that many other drugs and hormones influence memory through selective activation of the basolateral amygdala nucleus (BLA). This experiment examined whether the memory-modulatory effect of flumazenil, a benzodiazepine receptor antagonist, selectively involves the BLA. Bilateral microinfusions of flumazenil (12 nmol in 0.2 microl) into the BLA of rats administered immediately after training in an inhibitory avoidance task significantly enhanced 48-h retention performance whereas infusions into the central nucleus were ineffective. These findings indicate that the BLA is selectively involved in mediating flumazenil's influence on memory storage and are thus consistent with extensive evidence indicating that the BLA is involved in regulating memory consolidation.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Da Cunha C,Roozendaal B,Vazdarjanova A,McGaugh JL

doi

10.1006/nlme.1999.3912

keywords:

subject

Has Abstract

pub_date

1999-07-01 00:00:00

pages

1-7

issue

1

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(99)93912-6

journal_volume

72

pub_type

杂志文章

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