Abstract:
:The present experiment examined whether posttraining noradrenergic activity within the basolateral complex of the amygdala (BLA) is required for mediating the facilitating effects of acutely administered glucocorticoids on memory for auditory-cue classical fear conditioning. Male Sprague-Dawley rats received five pairings of a single-frequency auditory stimulus and footshock, followed immediately by bilateral infusions of the beta1-adrenoceptor antagonist atenolol (0.5 microg in 0.2 microl) or saline into the BLA together with a subcutaneous injection of either corticosterone (3.0 mg/kg) or vehicle. Retention was tested 24 h later in a novel test chamber and suppression of ongoing motor behavior served as the measure of conditioned fear. Corticosterone facilitated memory as assessed by suppression of motor activity during the 10-s presentation of the auditory stimulus and intra-BLA administration of atenolol selectively blocked this corticosterone-induced memory enhancement. These findings provide evidence that, as found with other emotionally arousing tasks, the enhancing effects of corticosterone on memory consolidation of auditory-cue fear conditioning require posttraining noradrenergic activity within the BLA.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Roozendaal B,Hui GK,Hui IR,Berlau DJ,McGaugh JL,Weinberger NMdoi
10.1016/j.nlm.2006.03.003subject
Has Abstractpub_date
2006-11-01 00:00:00pages
249-55issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(06)00032-3journal_volume
86pub_type
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