Molecular mechanisms controlling protein synthesis in memory reconsolidation.

abstract：:Attempts were made to further analyze the role of 5-HT1A receptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1A receptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the ...

journal_title：Neurobiology of learning and memory

authors： Meneses A,Hong E

更新日期：1999-03-01 00:00:00

abstract：:We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoid...

journal_title：Neurobiology of learning and memory

authors： Rawson T,O'Kane M,Talk A

更新日期：2010-01-01 00:00:00

abstract：:Mixed results with the synthetic β-adrenergic receptor blocker, propranolol, have been reported in human populations with regards to its therapeutic efficacy for PTSD treatments targeting the memory reconsolidation process. Stress alters the ability to form and maintain memory, but whether the causal neuronal mechanis...

journal_title：Neurobiology of learning and memory

authors： Hughes E,Shymansky T,Sunada H,Lukowiak K

更新日期：2016-12-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...

journal_title：Neurobiology of learning and memory

authors： Alvarenga TA,Patti CL,Andersen ML,Silva RH,Calzavara MB,Lopez GB,Frussa-Filho R,Tufik S

更新日期：2008-11-01 00:00:00

abstract：:The present work shows that the dorsomedial telencephalic pallium of teleost fish, proposed as homologous to the amygdala of mammals, is involved in taste aversion learning (TAL). To analyze the behavioral properties of TAL in goldfish, in Experiment 1, we used a delayed procedure similar to that employed with mammals...

journal_title：Neurobiology of learning and memory

authors： Martín I,Gómez A,Salas C,Puerto A,Rodríguez F

更新日期：2011-09-01 00:00:00

abstract：:N-methyl-D-aspartate receptors (NMDARs) are critically involved in various learning mechanisms including modulation of fear memory, brain development and brain disorders. While NMDARs mediate opposite effects on medial prefrontal cortex (mPFC) interneurons and excitatory neurons, NMDAR antagonists trigger profound cor...

journal_title：Neurobiology of learning and memory

authors： Vieira PA,Corches A,Lovelace JW,Westbrook KB,Mendoza M,Korzus E

更新日期：2015-03-01 00:00:00

abstract：:Cocaine experience affects motivation structures such as the nucleus accumbens (NAc) and its major output target, the ventral pallidum (VP). Previous studies demonstrated that both NAc activity and hedonic responses change reliably as a taste cue comes to predict cocaine availability. Here we extended this investigati...

journal_title：Neurobiology of learning and memory

authors： Chan CL,Wheeler DS,Wheeler RA

更新日期：2016-04-01 00:00:00

abstract：:Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...

journal_title：Neurobiology of learning and memory

authors： Buttigieg A,Flores O,Hernández A,Sáez-Briones P,Burgos H,Morgan C

更新日期：2014-01-01 00:00:00

abstract：:Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pai...

journal_title：Neurobiology of learning and memory

authors： Gould TJ,Higgins JS

更新日期：2003-09-01 00:00:00

abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Wong KL,Chavez CM,Leon MI,Robin KM,Weinberger NM

更新日期：2009-07-01 00:00:00

abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

journal_title：Neurobiology of learning and memory

authors： McKinney BC,Sze W,Lee B,Murphy GG

更新日期：2009-11-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

journal_title：Neurobiology of learning and memory

authors： Kuhlmann S,Kirschbaum C,Wolf OT

更新日期：2005-03-01 00:00:00

abstract：:The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become "destabilized". This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memories. One component of this process involves the rapid internalization of...

journal_title：Neurobiology of learning and memory

authors： Ferrara NC,Trask S,Pullins SE,Helmstetter FJ

更新日期：2019-12-01 00:00:00

abstract：:Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the ...

journal_title：Neurobiology of learning and memory

authors： Torregrossa MM,Corlett PR,Taylor JR

更新日期：2011-11-01 00:00:00

abstract：:The beneficial effects of caloric restriction (CR) on health and life expectancy are well documented, although its ability to slow down age-dependent cognitive decline and the underlying biochemical changes remains unclear. Therefore, the aim of this study was to investigate the effects of CR on spatial memory in aged...

journal_title：Neurobiology of learning and memory

authors： Rojic-Becker D,Portero-Tresserra M,Martí-Nicolovius M,Vale-Martínez A,Guillazo-Blanch G

更新日期：2019-12-01 00:00:00

abstract：:Sex differences in learned fear expression and extinction involve the medial prefrontal cortex (mPFC). We recently demonstrated that enhanced learned fear expression during auditory fear extinction and its recall is linked to persistent theta activation in the prelimbic (PL) but not infralimbic (IL) cortex of female r...

journal_title：Neurobiology of learning and memory

authors： Fenton GE,Halliday DM,Mason R,Bredy TW,Stevenson CW

更新日期：2016-11-01 00:00:00

abstract：:In the wild, house mice live in social groups, whereas in the laboratory male mice are often singly housed. Environmental enrichment such as that provided by social housing has been argued to improve the cognitive performance of laboratory animals in experimental tests. The aim of the present study was to test the cos...

journal_title：Neurobiology of learning and memory

authors： Fitchett AE,Collins SA,Barnard CJ,Cassaday HJ

更新日期：2005-11-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:Brief physical exercise enhances memories for neutral events, and recently has been shown to modulate fear learning in animals. To date there is no evidence pertaining to the impact of exercise on emotional memories in humans. Accordingly, this study investigated the role of brief exercise in the development of emotio...

journal_title：Neurobiology of learning and memory

authors： Keyan D,Bryant RA

更新日期：2017-05-01 00:00:00

abstract：:Recently developed neuroimaging and electrophysiological techniques are allowing us to answer fundamental questions about how behavioral states regulate our perception of the external environment. Studies using these techniques have yielded surprising insights into how sensory processing is affected at the earliest st...

journal_title：Neurobiology of learning and memory

authors： Aton SJ

更新日期：2013-11-01 00:00:00

abstract：:Anxiety disorders and obesity are both common in youth and young adults. Despite increasing evidence that over-consumption of palatable high-fat/high-sugar "junk" foods leads to adverse neurocognitive outcomes, little is known about the effects of palatable diets on emotional memories and fear regulation. In the prese...

journal_title：Neurobiology of learning and memory

authors： Baker KD,Reichelt AC

更新日期：2016-12-01 00:00:00

abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

journal_title：Neurobiology of learning and memory

authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

更新日期：2016-01-01 00:00:00

abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...

journal_title：Neurobiology of learning and memory

authors： Boccia MM,Blake MG,Baratti CM,McGaugh JL

更新日期：2009-01-01 00:00:00

abstract：:Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive a...

journal_title：Neurobiology of learning and memory

authors： Vanvossen AC,Portes MAM,Scoz-Silva R,Reichmann HB,Stern CAJ,Bertoglio LJ

更新日期：2017-01-01 00:00:00

abstract：:Considerable work demonstrates that Pavlovian fear conditioning depends on N-methyl-D-aspartate (NMDA) receptor-dependent plasticity within the amygdala. In addition, the bed nucleus of the stria terminalis (BNST) has also been implicated in fear conditioning, particularly in the expression of fear to poor predictors ...

journal_title：Neurobiology of learning and memory

authors： Ressler RL,Goode TD,Evemy C,Maren S

更新日期：2020-10-01 00:00:00

abstract：:Over the last decade, the interest in transcranial direct current stimulation (tDCS) has continued to increase, along with consideration of how it affects neuroplasticity mechanisms in the brain. Both human and animal studies have demonstrated numerous benefits and, although its application has increased, the neurophy...

journal_title：Neurobiology of learning and memory

authors： Stafford J,Brownlow ML,Qualley A,Jankord R

更新日期：2018-04-01 00:00:00

abstract：:Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and waterm...

journal_title：Neurobiology of learning and memory

authors： Müller N,Campbell S,Nonaka M,Rost TM,Pipa G,Konrad BN,Steiger A,Czisch M,Fernández G,Dresler M,Genzel L

更新日期：2018-05-01 00:00:00

abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...

journal_title：Neurobiology of learning and memory

authors： Foilb AR,Flyer-Adams JG,Maier SF,Christianson JP

更新日期：2016-10-01 00:00:00

abstract：:Medial thalamic damage is a common cause of severe memory disruption in humans. Both the anterior thalamic nuclei (ATN) and the intralaminar thalamic nuclei (ILN) have been suggested as primary sites of diencephalic injury underlying learning and memory deficits, but their respective roles have yet to be resolved. The...

journal_title：Neurobiology of learning and memory

authors： Wolff M,Gibb SJ,Cassel JC,Dalrymple-Alford JC

更新日期：2008-07-01 00:00:00