当前位置： SCI文献检索 > NEUROBIOLOGY OF LEARNING AND MEMORY期刊下所有文献 > Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.

Cholinergic modulation of trace conditioning trained in serial compound: A developmental analysis.

Abstract：

:In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague-Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age were shown to be capable of trace conditioning between a visual CS1 and a shock US, provided the trace interval was filled with a non-target CS2 during serial conditioning trials (CS1-->CS2-->US). To explore cholinergic mechanisms involved in trace and serial conditioning, additional experiments assessed conditioned responding following pre-training administration of the muscarinic receptor antagonist scopolamine. Scopolamine produced a dose-dependent reduction in responding to the trace CS1, regardless of whether subjects were trained with standard trace (CS1-->trace interval-->US) or serial (CS1-->CS2-->US) trials. Responding to CS2 was unaffected by scopolamine. These data suggest that central cholinergic systems are functional in the young animals, but are not normally sufficiently activated by standard trace conditioning procedures. The results suggest that serial compound conditioning can promote trace conditioning in young rats, as it does in adults, perhaps by enhancing cholinergic activity during training. Implications for the late ontogenetic emergence of trace conditioning as it relates to maturation of neural pathways and their role in the potentiating effects of a gap filler are discussed.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Hunt PS,Barnet RC,Shea ME,Baker EM

doi

10.1016/j.nlm.2006.05.001

subject

Has Abstract

pub_date

2006-11-01 00:00:00

pages

311-21

issue

3

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(06)00068-2

journal_volume

86

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF LEARNING AND MEMORY文献大全
  • Interaction of noradrenaline and cortisol predicts negative intrusive memories in posttraumatic stress disorder.

    abstract：:Recent evidence suggests that an interaction of noradrenaline (NE) and cortisol (CORT) during encoding leads to greater consolidation of emotional memories. Convergent models of posttraumatic stress disorder (PTSD) suggest the release of CORT and NE lead to greater intrusive memories in PTSD. This study examined the e...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2013.11.018

    authors： Nicholson EL,Bryant RA,Felmingham KL

    更新日期：2014-07-01 00:00:00

  • Hippocampal Arc (Arg3.1) expression is induced by memory recall and required for memory reconsolidation in trace fear conditioning.

    abstract：:Mounting evidence suggests that long-lasting, protein synthesis-dependent changes in synaptic strength accompany both the initial acquisition and subsequent recall of specific memories. Within brain areas thought to be important for learning and memory, including the hippocampus, learning-related plasticity is likely ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2013.06.021

    authors： Chia C,Otto T

    更新日期：2013-11-01 00:00:00

  • Memory enhancement by a semantically unrelated emotional arousal source induced after learning.

    abstract：:It has been well established that moderate physiological or emotional arousal modulates memory. However, there is some controversy about whether the source of arousal must be semantically related to the information to be remembered. To test this idea, 35 healthy young adult participants learned a list of common nouns ...

    journal_title：Neurobiology of learning and memory

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.nlm.2005.04.001

    authors： Nielson KA,Yee D,Erickson KI

    更新日期：2005-07-01 00:00:00

  • Influence of chronic corticosterone and glucocorticoid receptor antagonism in the amygdala on fear conditioning.

    abstract：:Glucocorticoid receptor activation within the basolateral amygdala (BLA) during fear conditioning may mediate enhancement in rats chronically exposed to stress levels of corticosterone. Male Sprague-Dawley rats received corticosterone (400 microg/ml) in their drinking water (days 1-21), a manipulation that was previou...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2004.01.002

    authors： Conrad CD,MacMillan DD 2nd,Tsekhanov S,Wright RL,Baran SE,Fuchs RA

    更新日期：2004-05-01 00:00:00

  • Differential effects of anterior and posterior insular cortex lesions on the acquisition of conditioned taste aversion and spatial learning.

    abstract：:In this study, we evaluated the effects of NMDA-induced lesions in different sites of the insular cortex of the rat on the acquisition of conditioned taste aversion and spatial learning in the Morris water maze. The lesions were produced by bilateral microinjections of NMDA in the insular cortex at +3.7 mm (Anterior g...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0042

    authors： Nerad L,Ramírez-Amaya V,Ormsby CE,Bermúdez-Rattoni F

    更新日期：1996-07-01 00:00:00

  • Conditioned tone control of brain reward behavior produces highly specific representational gain in the primary auditory cortex.

    abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2009.02.008

    authors： Hui GK,Wong KL,Chavez CM,Leon MI,Robin KM,Weinberger NM

    更新日期：2009-07-01 00:00:00

  • Scopolamine does not impact declarative and motor memory consolidation across a night of sleep or a day of wakefulness.

    abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.08.017

    authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

    更新日期：2018-11-01 00:00:00

  • Intra-medial prefrontal administration of SCH-23390 attenuates ERK phosphorylation and long-term memory for trace fear conditioning in rats.

    abstract：:The prefrontal cortex is known to be involved in the acquisition of trace conditioning, a higher-cognitive form of Pavlovian conditioning in which a conditioned stimulus and an unconditioned stimulus are separated by a time gap. We have recently reported that medial prefrontal (mPFC) extracellular-signal regulated kin...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2004.04.006

    authors： Runyan JD,Dash PK

    更新日期：2004-09-01 00:00:00

  • Dose-dependent impairing effects of morphine on avoidance acquisition and performance in male mice.

    abstract：:The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. H...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1997.3804

    authors： Aguilar MA,Miñarro J,Simón VM

    更新日期：1998-03-01 00:00:00

  • Asymmetrical number-space mapping in the avian brain.

    abstract：:When trained to peck a selected position in a sagittally-oriented series of identical food containers, and then required to generalize to an identical series rotated by 90°, chicks identify as correct only the target position from the left end, while choosing the right one at chance. Here we show that when accustomed ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2010.11.012

    authors： Rugani R,Vallortigara G,Vallini B,Regolin L

    更新日期：2011-03-01 00:00:00

  • Antagonizing the GABAA receptor during behavioral training improves spatial memory at different doses in control and chronically stressed rats.

    abstract：:Chronic stress leads to a dysregulated inhibitory tone that could impact hippocampal-dependent spatial learning and memory. The present study examined whether spatial memory deficits resulting from chronic stress could be overcome by antagonizing the GABAA receptor, a prominent inhibitory receptor of GABA in the hippo...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.09.002

    authors： Nishimura KJ,Ortiz JB,Conrad CD

    更新日期：2017-11-01 00:00:00

  • Polarity and subfield specific effects of transcranial direct current stimulation on hippocampal plasticity.

    abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.107126

    authors： Rohan JG,Miklasevich MK,McInturf SM,Bechmann NA,Moore RJ,Hatcher-Solis C,Jankord R

    更新日期：2020-01-01 00:00:00

  • Conditional knockout of MET receptor tyrosine kinase in cortical excitatory neurons leads to enhanced learning and memory in young adult mice but early cognitive decline in older adult mice.

    abstract：:Human genetic studies established MET gene as a risk factor for autism spectrum disorders. We have previously shown that signaling mediated by MET receptor tyrosine kinase, expressed in early postnatal developing forebrain circuits, controls glutamatergic neuron morphological development, synapse maturation, and corti...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2021.107397

    authors： Xia B,Wei J,Ma X,Nehme A,Liong K,Cui Y,Chen C,Gallitano A,Ferguson D,Qiu S

    更新日期：2021-01-29 00:00:00

  • Effects of postoperative housing conditions on functional recovery in rats with lesions of the hippocampus, subiculum, or entorhinal cortex.

    abstract：:In order to study the effects of differential housing conditions on recovery from damage to different components of the hippocampal formation, 85 rats received bilateral lesions of the hippocampus, entorhinal cortex, or subiculum or sham surgery and then were housed for 30 days in either an enriched environment or an ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.3745

    authors： Galani R,Jarrard LE,Will BE,Kelche C

    更新日期：1997-01-01 00:00:00

  • The neural basis of individual differences in memory performance in young and older adults: Using the encoding/retrieval flip account as framework.

    abstract：:Aging is associated with cognitive decline, specifically in episodic memory. However, there are large individual differences in the extent of this decline and previous research suggests that these are associated with differences in executive functioning (EF). These EF differences, and associated differences in the enc...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2020.107251

    authors： Fu L,Maes JHR,Kessels RPC,Huijbers W

    更新日期：2020-09-01 00:00:00

  • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease.

    abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2011.04.002

    authors： Stilling RM,Fischer A

    更新日期：2011-07-01 00:00:00

  • Impaired fear extinction retention and increased anxiety-like behaviours induced by limited daily access to a high-fat/high-sugar diet in male rats: Implications for diet-induced prefrontal cortex dysregulation.

    abstract：:Anxiety disorders and obesity are both common in youth and young adults. Despite increasing evidence that over-consumption of palatable high-fat/high-sugar "junk" foods leads to adverse neurocognitive outcomes, little is known about the effects of palatable diets on emotional memories and fear regulation. In the prese...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.10.002

    authors： Baker KD,Reichelt AC

    更新日期：2016-12-01 00:00:00

  • ORAI1-dependent synaptic plasticity in rat hippocampal neurons.

    abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.12.024

    authors： Tshuva RY,Korkotian E,Segal M

    更新日期：2017-04-01 00:00:00

  • Nicotine enhances contextual fear conditioning in C57BL/6J mice at 1 and 7 days post-training.

    abstract：:Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pai...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/s1074-7427(03)00057-1

    authors： Gould TJ,Higgins JS

    更新日期：2003-09-01 00:00:00

  • Effects of moderate treadmill exercise and fluoxetine on behavioural and cognitive deficits, hypothalamic-pituitary-adrenal axis dysfunction and alternations in hippocampal BDNF and mRNA expression of apoptosis - related proteins in a rat model of post-tr

    abstract：:Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need f...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.01.009

    authors： Shafia S,Vafaei AA,Samaei SA,Bandegi AR,Rafiei A,Valadan R,Hosseini-Khah Z,Mohammadkhani R,Rashidy-Pour A

    更新日期：2017-03-01 00:00:00

  • Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus.

    abstract：:Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and/or 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, a...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.07.001

    authors： Edinger KL,Frye CA

    更新日期：2007-01-01 00:00:00

  • Newly acquired and reactivated contextual fear memories are more intense and prone to generalize after activation of prelimbic cortex NMDA receptors.

    abstract：:Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive a...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.12.002

    authors： Vanvossen AC,Portes MAM,Scoz-Silva R,Reichmann HB,Stern CAJ,Bertoglio LJ

    更新日期：2017-01-01 00:00:00

  • Short-term treatment with flumazenil restores long-term object memory in a mouse model of Down syndrome.

    abstract：:Down syndrome (DS) is a common genetic cause of intellectual disability yet no pro-cognitive drug therapies are approved for human use. Mechanistic studies in a mouse model of DS (Ts65Dn mice) demonstrate that impaired cognitive function is due to excessive neuronal inhibitory tone. These deficits are normalized by ch...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.02.006

    authors： Colas D,Chuluun B,Garner CC,Heller HC

    更新日期：2017-04-01 00:00:00

  • Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult.

    abstract：:Cognitive impairments are amongst the most debilitating deficits of schizophrenia and the best predictor of functional outcome. Schizophrenia is hypothesized to have a neurodevelopmental origin, making animal models of neurodevelopmental insult important for testing predictions that early insults will impair cognitive...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.07.034

    authors： O'Reilly KC,Perica MI,Fenton AA

    更新日期：2016-10-01 00:00:00

  • Muscimol diffusion after intracerebral microinjections: a reevaluation based on electrophysiological and autoradiographic quantifications.

    abstract：:Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/micro...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2001.4035

    authors： Edeline JM,Hars B,Hennevin E,Cotillon N

    更新日期：2002-07-01 00:00:00

  • From Pavlov to PTSD: the extinction of conditioned fear in rodents, humans, and anxiety disorders.

    abstract：:Nearly 100 years ago, Ivan Pavlov demonstrated that dogs could learn to use a neutral cue to predict a biologically relevant event: after repeated predictive pairings, Pavlov's dogs were conditioned to anticipate food at the sound of a bell, which caused them to salivate. Like sustenance, danger is biologically releva...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2013.11.014

    authors： VanElzakker MB,Dahlgren MK,Davis FC,Dubois S,Shin LM

    更新日期：2014-09-01 00:00:00

  • Mice with targeted genetic reduction of GABA(A) receptor alpha1 subunits display performance differences in Morris water maze tasks.

    abstract：:Recent research has begun to demonstrate that specific subunits of GABA(A) receptors may be involved in the normal expression of specific behaviors. The present research used mice with GABA(A) receptors whose alpha1 subunits contained mutations of serine 270 to histidine and leucine 277 to alanine in the TM2 region. T...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2008.06.004

    authors： Berry RB,Werner DF,Wang X,Jablonski MM,Homanics GE,Mittleman G,Matthews DB

    更新日期：2008-10-01 00:00:00

  • Different types of exercise induce differential effects on neuronal adaptations and memory performance.

    abstract：:Different exercise paradigms show differential effects on various forms of memory. We hypothesize that the differential effects of exercises on memory performance are caused by different neuroplasticity changes in relevant brain regions in response to different exercise trainings. We examined the effects of treadmill ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2011.10.006

    authors： Lin TW,Chen SJ,Huang TY,Chang CY,Chuang JI,Wu FS,Kuo YM,Jen CJ

    更新日期：2012-01-01 00:00:00

  • Long-lasting alterations of hippocampal GABAergic neurotransmission in adult rats following perinatal Δ9-THC exposure.

    abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.12.023

    authors： Beggiato S,Borelli AC,Tomasini MC,Morgano L,Antonelli T,Tanganelli S,Cuomo V,Ferraro L

    更新日期：2017-03-01 00:00:00

  • Chronic high-frequency repetitive transcranial magnetic stimulation improves age-related cognitive impairment in parallel with alterations in neuronal excitability and the voltage-dependent Ca2+ current in female mice.

    abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.11.002

    authors： Wang HL,Xian XH,Wang YY,Geng Y,Han B,Wang MW,Li WB

    更新日期：2015-02-01 00:00:00