Free and nanoencapsulated curcumin suppress β-amyloid-induced cognitive impairments in rats: involvement of BDNF and Akt/GSK-3β signaling pathway.

abstract：:The single-trial passive avoidance task is a useful procedure for examining learning and memory in the young chick. However, it has recently been suggested that discrepant results reported by different laboratories are due to differences in training procedure. The present study investigated a number of parameters surr...

journal_title：Neurobiology of learning and memory

authors： Crowe SF,Hale MW

更新日期：2002-09-01 00:00:00

abstract：:Glucocorticoid receptor activation within the basolateral amygdala (BLA) during fear conditioning may mediate enhancement in rats chronically exposed to stress levels of corticosterone. Male Sprague-Dawley rats received corticosterone (400 microg/ml) in their drinking water (days 1-21), a manipulation that was previou...

journal_title：Neurobiology of learning and memory

authors： Conrad CD,MacMillan DD 2nd,Tsekhanov S,Wright RL,Baran SE,Fuchs RA

更新日期：2004-05-01 00:00:00

abstract：:Mounting evidence suggests that long-lasting, protein synthesis-dependent changes in synaptic strength accompany both the initial acquisition and subsequent recall of specific memories. Within brain areas thought to be important for learning and memory, including the hippocampus, learning-related plasticity is likely ...

journal_title：Neurobiology of learning and memory

authors： Chia C,Otto T

更新日期：2013-11-01 00:00:00

abstract：:Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activati...

journal_title：Neurobiology of learning and memory

authors： Metherate R,Hsieh CY

更新日期：2003-11-01 00:00:00

abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

journal_title：Neurobiology of learning and memory

authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

更新日期：2021-01-19 00:00:00

abstract：:The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng)....

journal_title：Neurobiology of learning and memory

authors： Stoehr JD,Mobley SL,Roice D,Brooks R,Baker LM,Wiley RG,Wenk GL

更新日期：1997-05-01 00:00:00

abstract：:Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor(6) (5-HT(6)) improve memory and reverse amnesia although the mechanisms involved are poorly understood. Hence, in this paper RT-PCR was used to evaluate changes in mRNA expression of 5-HT(6) receptor in trained and untrained ra...

journal_title：Neurobiology of learning and memory

authors： Huerta-Rivas A,Pérez-García G,González-Espinosa C,Meneses A

更新日期：2010-01-01 00:00:00

abstract：:Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g., visuospatial interference tasks, like Tetris) have been shown to be effective at disrupting reactivated memory. In the present study, participants created a memory ...

journal_title：Neurobiology of learning and memory

authors： Gotthard GH,Gura H

更新日期：2018-12-01 00:00:00

abstract：:In the marine snail Hermissenda, associative learning can be accomplished by paired presentations of light and vestibular stimulation. It is generally assumed that associative learning depends upon the intensity or salience of the conditioned or unconditioned stimulus (CS and US, respectively). Accordingly, during Her...

journal_title：Neurobiology of learning and memory

authors： Tomsic D,Alkon DL

更新日期：2000-07-01 00:00:00

abstract：:Inactivation of the rodent medial prefrontal cortex (mPFC) and hippocampus or disconnection of the hippocampus from the mPFC produces deficits in spatial working memory tasks. Previous studies have shown that delay length determines the extent to which mPFC and hippocampus functionally interact, with both structures b...

journal_title：Neurobiology of learning and memory

authors： Layfield DM,Patel M,Hallock H,Griffin AL

更新日期：2015-11-01 00:00:00

abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

journal_title：Neurobiology of learning and memory

authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

更新日期：2016-01-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:Although tissue type plasminogen activator (tPA) and brain derived neurotrophic factor (BDNF) have been extensively described to influence brain outcomes in a number of disorders, their roles during physiological aging are poorly investigated. In the present study, we investigated whether maintenance of mice in differ...

journal_title：Neurobiology of learning and memory

authors： Obiang P,Maubert E,Bardou I,Nicole O,Launay S,Bezin L,Vivien D,Agin V

更新日期：2011-09-01 00:00:00

abstract：:Spatial orientation is a cognitive ability that is indispensable for survival. Several visual distal cues present in the context can be integrated, establishing a cognitive map. Although there is cumulative evidence about the neural substrate involved in spatial memory acquisition, the brain networks mediating the pro...

journal_title：Neurobiology of learning and memory

authors： Zorzo C,Arias JL,Méndez M

更新日期：2020-11-01 00:00:00

abstract：:Over the past several years, drug addiction has increasingly been accepted to be a disease of the brain as opposed to simply being due to a lack of willpower or personality flaw. Exposure to addictive substances has been shown to create enduring changes in brain structure and function that are thought to underlie the ...

journal_title：Neurobiology of learning and memory

authors： Torregrossa MM,Corlett PR,Taylor JR

更新日期：2011-11-01 00:00:00

abstract：:An enormous amount of research has been aimed at identifying biological and environmental factors that are contributing to the current global obesity pandemic. The present paper reviews recent findings which suggest that obesity is attributable, at least in part, to a disruption of the Pavlovian control of energy regu...

journal_title：Neurobiology of learning and memory

authors： Davidson TL,Sample CH,Swithers SE

更新日期：2014-02-01 00:00:00

abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

journal_title：Neurobiology of learning and memory

authors： Stilling RM,Fischer A

更新日期：2011-07-01 00:00:00

abstract：:Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its con...

journal_title：Neurobiology of learning and memory

authors： Oyanedel CN,Sawangjit A,Born J,Inostroza M

更新日期：2019-04-01 00:00:00

abstract：:We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoid...

journal_title：Neurobiology of learning and memory

authors： Rawson T,O'Kane M,Talk A

更新日期：2010-01-01 00:00:00

abstract：:Attempts were made to further analyze the role of 5-HT1A receptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1A receptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the ...

journal_title：Neurobiology of learning and memory

authors： Meneses A,Hong E

更新日期：1999-03-01 00:00:00

abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...

journal_title：Neurobiology of learning and memory

authors： Rohan JG,Miklasevich MK,McInturf SM,Bechmann NA,Moore RJ,Hatcher-Solis C,Jankord R

更新日期：2020-01-01 00:00:00

abstract：:MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement...

journal_title：Neurobiology of learning and memory

authors： Gulmez Karaca K,Brito DVC,Zeuch B,Oliveira AMM

更新日期：2018-03-01 00:00:00

abstract：:Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Here we show that if Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, which at either site alone are insuff...

journal_title：Neurobiology of learning and memory

authors： Sherff CM,Carew TJ

更新日期：2002-11-01 00:00:00

abstract：:Sleep loss affects emotional memory, but the specific effects on its contextual and non-contextual aspects are unknown. In this study we investigated the possible differential influence of one night of sleep deprivation on the encoding and subsequent recall of these two aspects of emotional information. Forty-eight he...

journal_title：Neurobiology of learning and memory

authors： Tempesta D,Socci V,Coppo M,Dello Ioio G,Nepa V,De Gennaro L,Ferrara M

更新日期：2016-05-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is abundantly expressed in postmitotic neurons of the developed nervous system. MAPK is activated and required for induction of long-term potentiation (LTP) in the CA1 area of the hippocampus, which is blocked by the specific inhibitor of the MAPK kinase, PD 098059. Recently it ...

journal_title：Neurobiology of learning and memory

authors： Walz R,Roesler R,Quevedo J,Sant'Anna MK,Madruga M,Rodrigues C,Gottfried C,Medina JH,Izquierdo I

更新日期：2000-01-01 00:00:00

abstract：:The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...

journal_title：Neurobiology of learning and memory

authors： Oboh AM,Paredes RG,Baum MJ

更新日期：1995-01-01 00:00:00

abstract：:The amygdala, medial hypothalamus, dorsal periaqueductal gray (dPAG), superior and inferior colliculus together constitutes the encephalic aversion system which has been considered the main neural substrate for the integration of unconditioned aversive behavioral states. Within the amygdala the basolateral nucleus (BL...

journal_title：Neurobiology of learning and memory

authors： Carvalho MC,Santos JM,Bassi GS,Brandão ML

更新日期：2013-05-01 00:00:00

abstract：:Adult male Wistar rats with a substantia nigra pars compacta (SNc) lesion induced by intranigral administration of 1 micromol 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) were used as a model of early phase Parkinson's disease (PD). This lesion caused a partial depletion of striatal dopamine (DA). The animals w...

journal_title：Neurobiology of learning and memory

authors： Bellissimo MI,Kouzmine I,Ferro MM,de Oliveira BH,Canteras NS,Da Cunha C

更新日期：2004-09-01 00:00:00

abstract：:Formation of long-term memories requires coordinated gene expression, which can be regulated at transcriptional, post-transcriptional, and translational levels. Post-transcriptional stabilization and destabilization of mRNAs provides precise temporal and spatial regulation of gene expression, which is critical for con...

journal_title：Neurobiology of learning and memory

authors： Lee YS,Lee JA,Kaang BK

更新日期：2015-10-01 00:00:00

abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...

journal_title：Neurobiology of learning and memory

authors： Turner LF,Liu Z,Bures J

更新日期：1997-07-01 00:00:00