Time-course of 5-HT(6) receptor mRNA expression during memory consolidation and amnesia.

abstract：:Learning is ubiquitous in the animal kingdom but has been studied extensively in only a handful of species. Moreover, learning studied under laboratory conditions is typically unrelated to the animal's natural environment or life history. Here, we designed a task relevant to the natural behavior of male African cichli...

journal_title：Neurobiology of learning and memory

authors： Wood LS,Desjardins JK,Fernald RD

更新日期：2011-03-01 00:00:00

abstract：:Effects of estradiol benzoate (EB), ERα-selective agonist, propyl pyrazole triol (PPT) and ERβ-selective agonists, diarylpropionitrile (DPN) and Compound 19 (C-19) on memory were investigated in OVX rats using object recognition (OR) and placement (OP) memory tasks. Treatments were acute (behavior 4h later) or sub chr...

journal_title：Neurobiology of learning and memory

authors： Jacome LF,Gautreaux C,Inagaki T,Mohan G,Alves S,Lubbers LS,Luine V

更新日期：2010-11-01 00:00:00

abstract：:Spatial orientation is a cognitive ability that is indispensable for survival. Several visual distal cues present in the context can be integrated, establishing a cognitive map. Although there is cumulative evidence about the neural substrate involved in spatial memory acquisition, the brain networks mediating the pro...

journal_title：Neurobiology of learning and memory

authors： Zorzo C,Arias JL,Méndez M

更新日期：2020-11-01 00:00:00

abstract：:Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippoca...

journal_title：Neurobiology of learning and memory

authors： Hales JB,Ocampo AC,Broadbent NJ,Clark RE

更新日期：2016-12-01 00:00:00

abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...

journal_title：Neurobiology of learning and memory

authors： Turner LF,Liu Z,Bures J

更新日期：1997-07-01 00:00:00

abstract：:Pre-verbal infants and non-human animals associate small numbers with the left space and large numbers with the right space. Birds and primates, trained to identify a given position in a sagittal series of identical positions, whenever required to respond on a left/right oriented series, referred the given position st...

journal_title：Neurobiology of learning and memory

authors： Rugani R,Vallortigara G,Regolin L

更新日期：2016-09-01 00:00:00

abstract：:Neuronal plasticity and neurogenesis occur in the adult hippocampus and in other brain structures such as the olfactory bulb and often involve the neural cell adhesion molecule NCAM. During an olfactory associative discrimination learning task, NCAM polysialylation triggers neuronal plasticity in the adult hippocampus...

journal_title：Neurobiology of learning and memory

authors： Mione J,Manrique C,Duhoo Y,Roman FS,Guiraudie-Capraz G

更新日期：2016-04-01 00:00:00

abstract：:The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. H...

journal_title：Neurobiology of learning and memory

authors： Aguilar MA,Miñarro J,Simón VM

更新日期：1998-03-01 00:00:00

abstract：:We have previously reported that extinction of escape behavior in the water maze due to the removal of the platform coincided with the development of behavioral "despair" in aged and adult rats, as assessed by immobility. The present study examines further predictions derived from the hypothesis that the withholding o...

journal_title：Neurobiology of learning and memory

authors： Schulz D,Huston JP,Buddenberg T,Topic B

更新日期：2007-03-01 00:00:00

abstract：:Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in diff...

journal_title：Neurobiology of learning and memory

authors： Masuda A,Kobayashi Y,Kogo N,Saito T,Saido TC,Itohara S

更新日期：2016-11-01 00:00:00

abstract：:Memory consolidation is associated with sleep physiology but the contribution of specific sleep stages remains controversial. To clarify the contribution of REM sleep, participants were administered two REM sleep-sensitive tasks to determine if associated changes occurred only in REM sleep. Twenty-two participants (7 ...

journal_title：Neurobiology of learning and memory

authors： Nielsen T,O'Reilly C,Carr M,Dumel G,Godin I,Solomonova E,Lara-Carrasco J,Blanchette-Carrière C,Paquette T

更新日期：2015-07-01 00:00:00

abstract：:The therapeutic efficacy of the synthetic β-adrenergic receptor blocker, propranolol, for the treatment of post-traumatic stress disorder (PTSD) is currently being debated. Mixed results have been published regarding propranolol's ability to disrupt the consolidation and reconsolidation of memories. Here, we use the i...

journal_title：Neurobiology of learning and memory

authors： Shymansky T,Hughes E,Rothwell CM,Lukowiak K

更新日期：2018-03-01 00:00:00

abstract：:Inactivation of the rodent medial prefrontal cortex (mPFC) and hippocampus or disconnection of the hippocampus from the mPFC produces deficits in spatial working memory tasks. Previous studies have shown that delay length determines the extent to which mPFC and hippocampus functionally interact, with both structures b...

journal_title：Neurobiology of learning and memory

authors： Layfield DM,Patel M,Hallock H,Griffin AL

更新日期：2015-11-01 00:00:00

abstract：:Cocaine experience affects motivation structures such as the nucleus accumbens (NAc) and its major output target, the ventral pallidum (VP). Previous studies demonstrated that both NAc activity and hedonic responses change reliably as a taste cue comes to predict cocaine availability. Here we extended this investigati...

journal_title：Neurobiology of learning and memory

authors： Chan CL,Wheeler DS,Wheeler RA

更新日期：2016-04-01 00:00:00

abstract：:Early life adverse events can lead to structural and functional impairments in the prefrontal cortex (PFC). Here, we investigated whether maternal deprivation (MD) alters PFC-dependent executive functions, neurons and astrocytes number and synaptic plasticity in adult male Long-Evans rats. The deprivation protocol con...

journal_title：Neurobiology of learning and memory

authors： Baudin A,Blot K,Verney C,Estevez L,Santamaria J,Gressens P,Giros B,Otani S,Daugé V,Naudon L

更新日期：2012-10-01 00:00:00

abstract：:In a previous study, adult male Sprague-Dawley rats with unilateral, electrolytic entorhinal cortex lesions showed significant deficits in acquisition of a water maze task that measured working memory. The 10 days of testing used two trials per day with an intertrial interval of 1 h, and the rats with entorhinal damag...

journal_title：Neurobiology of learning and memory

authors： Glasier MM,Janis LS,Roof RL,Stein DG

更新日期：1999-01-01 00:00:00

abstract：:The prefrontal cortex is known to be involved in the acquisition of trace conditioning, a higher-cognitive form of Pavlovian conditioning in which a conditioned stimulus and an unconditioned stimulus are separated by a time gap. We have recently reported that medial prefrontal (mPFC) extracellular-signal regulated kin...

journal_title：Neurobiology of learning and memory

authors： Runyan JD,Dash PK

更新日期：2004-09-01 00:00:00

abstract：:Synaptic plasticity is subject to activity-dependent long-term modification (metaplasticity). We have recently described a novel form of heterosynaptic metaplasticity in hippocampal CA1, whereby 'priming' activity at one set of synapses confers a metaplastic state that inhibits subsequent LTP both within and between d...

journal_title：Neurobiology of learning and memory

authors： Jones OD,Hulme SR,Abraham WC

更新日期：2013-10-01 00:00:00

abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...

journal_title：Neurobiology of learning and memory

authors： Boccia MM,Blake MG,Baratti CM,McGaugh JL

更新日期：2009-01-01 00:00:00

abstract：:The protein product of the immediate-early gene, c-fos, was visualized immunocytochemically in forebrain neurons of gonadectomized male and female rats which were injected daily with testosterone propionate (TP) and either tested for mounting directed toward a sexually receptive female or left alone in a test arena. L...

journal_title：Neurobiology of learning and memory

authors： Oboh AM,Paredes RG,Baum MJ

更新日期：1995-01-01 00:00:00

abstract：:Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant ...

journal_title：Neurobiology of learning and memory

authors： Cunha-Rodrigues MC,Balduci CTDN,Tenório F,Barradas PC

更新日期：2018-03-01 00:00:00

abstract：:Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial for restoring cognitive abilities in individuals with DS. Attention...

journal_title：Neurobiology of learning and memory

authors： Heller HC,Salehi A,Chuluun B,Das D,Lin B,Moghadam S,Garner CC,Colas D

更新日期：2014-12-01 00:00:00

abstract：:The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become "destabilized". This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memories. One component of this process involves the rapid internalization of...

journal_title：Neurobiology of learning and memory

authors： Ferrara NC,Trask S,Pullins SE,Helmstetter FJ

更新日期：2019-12-01 00:00:00

abstract：:Adenosine, a purine ribonucleoside, exhibits neuromodulatory and neuroprotective effects in the brain and is involved in memory formation and cognitive function. Adenosine signaling is mediated by adenosine receptors (A1, A2A, A2B, and A3); in turn, nucleotide and nucleoside-metabolizing enzymes and adenosine transpor...

journal_title：Neurobiology of learning and memory

authors： Bortolotto JW,Melo GM,Cognato Gde P,Vianna MR,Bonan CD

更新日期：2015-02-01 00:00:00

abstract：:Based on computational models of the hippocampus, it has been suggested that a possible mechanism for memory retrieval is pattern completion, wherein an autoassociative network recalls previous patterns of activity given noisy or degraded cues. However, there are few behavioral data examining pattern completion per se...

journal_title：Neurobiology of learning and memory

authors： Kirwan CB,Gilbert PE,Kesner RP

更新日期：2005-01-01 00:00:00

abstract：:Recent data have demonstrated a biochemical sequence of events in the rat hippocampus that is necessary for memory formation of inhibitory avoidance behavior. The sequence initially involves the activation of three different types of glutamate receptors followed by changes in second messengers and biochemical cascades...

journal_title：Neurobiology of learning and memory

authors： Izquierdo I,Medina JH

更新日期：1997-11-01 00:00:00

abstract：:In four experiments the effects of serial compound conditioning on responding to a trace-conditioned CS were evaluated using a fear conditioning paradigm. The subjects were 18- and 25-day-old Sprague-Dawley rats, previously shown to exhibit little or no trace fear conditioning. Here, animals as young as 18 days of age...

journal_title：Neurobiology of learning and memory

authors： Hunt PS,Barnet RC,Shea ME,Baker EM

更新日期：2006-11-01 00:00:00

abstract：:The dynamics of learning in the Active Avoidance test was analyzed at the trials level as well as at the level of daily sessions, each comprising numerous trials. The two scales (large scale for the sessions and small scale for the trials) were demonstrated to be mutually independent. The intermediate derived scales (...

journal_title：Neurobiology of learning and memory

authors： Giuliani A,Mancini AM,Ghirardi O,Ramacci MT,Voronina T,Sirabella P,Colosimo A

更新日期：1996-01-01 00:00:00

abstract：:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippo...

journal_title：Neurobiology of learning and memory

authors： Krawczyk MC,Navarro N,Blake MG,Romano A,Feld M,Boccia MM

更新日期：2016-09-01 00:00:00

abstract：:The entorhinal cortex (EC) has been shown to be an integral piece of the hippocampal memory system. It sits in a unique position within the brain with strong, intricate, reciprocal connectivity with the hippocampus as well as a vast array of neocortical regions. Topographical patterns of afferent and efferent projecti...

journal_title：Neurobiology of learning and memory

authors： Morrissey MD,Takehara-Nishiuchi K

更新日期：2014-11-01 00:00:00