Abstract：
:Synaptic plasticity is subject to activity-dependent long-term modification (metaplasticity). We have recently described a novel form of heterosynaptic metaplasticity in hippocampal CA1, whereby 'priming' activity at one set of synapses confers a metaplastic state that inhibits subsequent LTP both within and between dendritic compartments. Here, we investigated the roles of purinergic signalling and gap junctions in mediating this long-distance communication between synapses. We found that the heterosynaptic metaplasticity requires the hydrolysis of extracellular ATP to adenosine, and activation of adenosine A2, but not A1 receptors. The metaplasticity was also blocked by the non-selective gap junction blockers carbenoxolone and meclofenamic acid, and by a connexin43-specific mimetic peptide. These results indicate that an intercellular signalling cascade underlies the long-distance communication required for this form of metaplasticity.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Jones OD,Hulme SR,Abraham WCdoi
10.1016/j.nlm.2013.05.010subject
Has Abstractpub_date
2013-10-01 00:00:00pages
31-9eissn
1074-7427issn
1095-9564pii
S1074-7427(13)00091-9journal_volume
105pub_type
杂志文章abstract：:Previous evidence suggests that a high-salt (HS) diet may increase oxidative stress and contribute to the development of hypertension that is already present. Oxidative stress is thought to play a critical role in the development of neurodegenerative diseases. Lower dietary sodium intake putatively contributes to a lo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2014.04.010
更新日期：2014-10-01 00:00:00
abstract：:An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose pok...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.01.002
更新日期：2008-07-01 00:00:00
abstract：:Primary sensory cortical fields develop highly specific associative representational plasticity, notably enlarged area of representation of reinforced signal stimuli within their topographic maps. However, overtraining subjects after they have solved an instrumental task can reduce or eliminate the expansion while the...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：:Although no single widely accepted animal model of PTSD has been established to date, the single prolonged stress (SPS) animal model has been partially validated as a model for PTSD. SPS rats mimic the pathophysiological abnormalities and behavioral characteristics of PTSD, such as enhanced fear response to the trauma...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2013.02.003
更新日期：2013-05-01 00:00:00
abstract：:Activity dependent calcium entry into neurons can initiate a form of synaptic plasticity called long-term potentiation (LTP). This phenomenon is considered by many to be one possible cellular mechanism underlying learning and memory. The calcium entry that induces this phenomenon can occur when N-methyl-D-aspartate re...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2003.10.003
更新日期：2004-03-01 00:00:00
abstract：:Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/s1074-7427(02)00020-5
更新日期：2003-03-01 00:00:00
abstract：:The posterior parietal cortex (PPC) of rats has most recently been defined based on patterns of thalamic and cortical connectivity. The anatomical characteristics of this area suggest that it may be homologous to the PPC of primates and contribute to similar functions. This review summarizes evidence for and against a...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2008.07.004
更新日期：2009-02-01 00:00:00
abstract：:In spite of evidence about negative effects of Nandrolone Decanoate (ND) on cognitive and memory performance, the underlying mechanisms are complex and have remained unclear. This research examines the role of Calcineurin in synaptic plasticity and memory storage impairment in ND administrated adolescent male rats. Fo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.107032
更新日期：2019-09-01 00:00:00
abstract：:Memory consolidation is associated with sleep physiology but the contribution of specific sleep stages remains controversial. To clarify the contribution of REM sleep, participants were administered two REM sleep-sensitive tasks to determine if associated changes occurred only in REM sleep. Twenty-two participants (7 ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2014.09.007
更新日期：2015-07-01 00:00:00
abstract：:The consolidation of newly formed memories occurs slowly, allowing memories to be altered by experience for some time after their formation. Various treatments, including arousal, can modulate memory consolidation when given soon after learning, but the degree of time-dependency of these treatments in humans has not b...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.03.005
更新日期：2007-07-01 00:00:00
abstract：:Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.07.012
更新日期：2009-01-01 00:00:00
abstract：:We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoid...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.09.003
更新日期：2010-01-01 00:00:00
abstract：:New neurons are continually produced in the adult mammalian brain from progenitor cells located in specific brain regions, including the subgranular zone (SGZ) of the dentate gyrus of the hippocampus. We hypothesized that neurogenesis occurs in the canine brain and is reduced with age. We examined neurogenesis in the ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.05.001
更新日期：2007-09-01 00:00:00
abstract：:Carriers of a FMR1 premutation allele (between 55 and 199 CGG repeats) are at risk of developing a wide range of medical, psychiatric and cognitive disorders, including executive dysfunction. These cognitive deficits are often less severe for female premutation carriers compared to male premutation carriers, albeit si...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2017.07.002
更新日期：2017-10-01 00:00:00
abstract：:The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of whether intranasally applied pregnenolone (IN-PREG) also has promnestic properties in the rat. We examined the effects of IN-PREG at doses of 0.187 and 0.373mg/kg on memo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.07.012
更新日期：2016-09-01 00:00:00
abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2017.05.009
更新日期：2017-07-01 00:00:00
abstract：:Although septal infusions of glucose typically have positive effects on memory, we have shown repeatedly that this treatment exacerbates memory deficits produced by co-infusions of gamma-aminobutyric acid (GABA) receptor agonists. The present experiments tested whether this negative interaction between glucose and GAB...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2007.07.008
更新日期：2008-02-01 00:00:00
abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.02.008
更新日期：2009-07-01 00:00:00
abstract：:Numerous preclinical studies show that acute cannabinoid administration impairs cognitive performance. Almost all of this research has employed cannabinoid injections, however, whereas smoking is the preferred route of cannabis administration in humans. The goal of these experiments was to systematically determine how...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.12.001
更新日期：2019-01-01 00:00:00
abstract：:There is extensive evidence that post-training administration of the adrenocortical hormone corticosterone facilitates memory consolidation processes in a variety of contextual and spatial-dependent learning situations. The present experiments examine whether corticosterone can modulate memory of auditory-cue classica...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2003.09.002
更新日期：2004-01-01 00:00:00
abstract：:The two main objectives of this study were (1) to replicate previous findings that 6 days of binge-like exposure to alcohol during the neonatal brain growth spurt induces significant place learning deficits in juvenile rats and (2) to determine whether more limited (3-day) binge-like exposure during the neonatal perio...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1995.0009
更新日期：1995-11-01 00:00:00
abstract：:Mounting evidence suggests that long-lasting, protein synthesis-dependent changes in synaptic strength accompany both the initial acquisition and subsequent recall of specific memories. Within brain areas thought to be important for learning and memory, including the hippocampus, learning-related plasticity is likely ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2013.06.021
更新日期：2013-11-01 00:00:00
abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.12.023
更新日期：2017-03-01 00:00:00
abstract：:Epidemiological studies demonstrated association between head injury (HI) and the subsequent development of Alzheimer's disease (AD). Certain hallmarks of AD, e.g. amyloid-β (Aβ) containing deposits, may be found in patients following traumatic BI (TBI). Recent studies uncover the cellular prion protein, PrP(C), as a ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2013.10.019
更新日期：2014-01-01 00:00:00
abstract：:Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2016.11.013
更新日期：2017-01-01 00:00:00
abstract：:Corticosterone (CORT), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion CA3. We tested the hypothesis that CORT would impair spatial memory, a hippocampal function. In each of the three experiments, rats received daily, subcutaneous injections of either CORT (26.8 mg/kg bod...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/s1074-7427(03)00019-4
更新日期：2003-07-01 00:00:00
abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2005.09.004
更新日期：2006-03-01 00:00:00
abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.04.009
更新日期：2019-05-01 00:00:00
abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.06.012
更新日期：2009-11-01 00:00:00
abstract：:Temporal lobe epilepsy patients have demonstrated a relative preservation in the integrity of implicit memory procedures. We examined performance in a verbal implicit and explicit memory task in left anterior temporal lobectomy patients (LATL) and healthy normal controls (NCs) while undergoing fMRI. We hypothesized th...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.08.005
更新日期：2012-10-01 00:00:00
