Abstract:
:The two main objectives of this study were (1) to replicate previous findings that 6 days of binge-like exposure to alcohol during the neonatal brain growth spurt induces significant place learning deficits in juvenile rats and (2) to determine whether more limited (3-day) binge-like exposure during the neonatal period induces place learning deficits and whether the effects depend on the developmental timing of the exposure. Using artificial rearing methods and a split-litter experimental design, groups of male and female neonatal rats were given binge-like exposure to 4.5 g/kg/day of ethanol in milk formula either on Postnatal Days (PD) 4-6, PD 7-9, or PD 4-9, which yielded mean peak blood alcohol concentrations of 230-260 mg/dl. Controls included an artificially reared gastrostomy control group (GC) given an isocaloric milk formula diet on PD 4-9 and a suckle control group reared normally by lactating dams. Acquisition of place learning in the Morris spatial navigation task was trained for 6 consecutive days beginning on PD 26; a probe trial was given at the end of the sixth day. As expected, both males and females given alcohol on PD 4-9 had significant deficits in acquisition and probe trial performance relative to SC and GC groups. Males given the PD 7-9 exposure had significant place learning deficits which were as severe as with the full 6-day exposure. The PD 4-6 exposure in males produced only a nonsignificant trend toward slower acquisition. Females were not significantly affected by either 3-day exposure. The latter phase of the neonatal brain growth spurt appears to constitute a sex-specific period of enhanced vulnerability to alcohol-induced developmental spatial learning deficits.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Goodlett CR,Peterson SDdoi
10.1006/nlme.1995.0009subject
Has Abstractpub_date
1995-11-01 00:00:00pages
265-75issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(85)70009-3journal_volume
64pub_type
杂志文章abstract::Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...
journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2012.08.004
更新日期:2012-10-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2003.09.002
更新日期:2004-01-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2004.04.006
更新日期:2004-09-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2007.05.007
更新日期:2008-02-01 00:00:00
abstract::Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2020.107355
更新日期:2021-01-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1995.1017
更新日期:1995-03-01 00:00:00
abstract::Acetylcholine plays an important role in regulating the processing of sensory stimuli, and understanding its specific cellular actions is critical to understanding how sensory cortex develops and functions in different behavioral states. Here we review recent work on the cellular effects of nicotinic receptor activati...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/s1074-7427(03)00062-5
更新日期:2003-11-01 00:00:00
abstract::The current review provides a historical perspective on the evolution of hypothesized mechanisms for senescent neurophysiology, focused on the CA1 region of the hippocampus, and the relationship of senescent neurophysiology to impaired hippocampal-dependent memory. Senescent neurophysiology involves processes linked t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2019.107064
更新日期:2019-10-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3841
更新日期:1998-07-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2015.11.020
更新日期:2016-01-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2018.09.005
更新日期:2018-11-01 00:00:00
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2003.10.003
更新日期:2004-03-01 00:00:00
abstract::Activity in the rodent prelimbic (PL) cortex contributes to consolidation, retrieval and reconsolidation of learned fear. The PL cortex is considered homologous to the primate dorsal anterior cingulate cortex (dACC). In patients with post-traumatic stress disorder (PTSD), the dACC is often reported to be hyperactive a...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.12.002
更新日期:2017-01-01 00:00:00
abstract::Aiming at exploring the brain's structural organisation underlying successful second language learning, we investigate the anatomy of the perisylvian language network in a group of healthy adults, consisting of participants with high and average language analytical abilities. Utilising deterministic tractography, six ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2017.07.003
更新日期:2017-10-01 00:00:00
abstract::Several studies using inhibitory avoidance models have demonstrated the importance of limbic structures, such as the amygdala, dorsal hippocampus and medial prefrontal cortex, in the consolidation of emotional memory. However, we aimed to investigate the role of the amygdala (AMG), dorsal hippocampus (DH) and medial p...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.01.012
更新日期:2016-04-01 00:00:00
abstract::Effects of estradiol benzoate (EB), ERα-selective agonist, propyl pyrazole triol (PPT) and ERβ-selective agonists, diarylpropionitrile (DPN) and Compound 19 (C-19) on memory were investigated in OVX rats using object recognition (OR) and placement (OP) memory tasks. Treatments were acute (behavior 4h later) or sub chr...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2010.08.016
更新日期:2010-11-01 00:00:00
abstract::Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...
journal_title:Neurobiology of learning and memory
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/j.nlm.2004.09.001
更新日期:2005-03-01 00:00:00
abstract::Reinforcement learning enables organisms to adjust their behavior in order to maximize rewards. Electrophysiological recordings of dopaminergic midbrain neurons have shown that they code the difference between actual and predicted rewards, i.e., the reward prediction error, in many species. This error signal is convey...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2014.05.002
更新日期:2014-10-01 00:00:00
abstract::Previous studies have reported that drugs affecting neuromodulatory systems within the basolateral amygdala (BLA), including drugs affecting muscarinic cholinergic receptors, modulate the consolidation of many kinds of training, including contextual fear conditioning (CFC). The present experiments investigated the inv...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2008.07.012
更新日期:2009-01-01 00:00:00
abstract::The posterior parietal cortex (PPC) of rats has most recently been defined based on patterns of thalamic and cortical connectivity. The anatomical characteristics of this area suggest that it may be homologous to the PPC of primates and contribute to similar functions. This review summarizes evidence for and against a...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2008.07.004
更新日期:2009-02-01 00:00:00