Postnatal exposure to poly (I:C) impairs learning and memory through changes in synaptic plasticity gene expression in developing rat brain.

abstract：:Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, t...

journal_title：Neurobiology of learning and memory

authors： Cai R,Zhou X,Guo F,Xu J,Zhang J,Sun X

更新日期：2010-11-01 00:00:00

abstract：:The present experiment examined whether posttraining noradrenergic activity within the basolateral complex of the amygdala (BLA) is required for mediating the facilitating effects of acutely administered glucocorticoids on memory for auditory-cue classical fear conditioning. Male Sprague-Dawley rats received five pair...

journal_title：Neurobiology of learning and memory

authors： Roozendaal B,Hui GK,Hui IR,Berlau DJ,McGaugh JL,Weinberger NM

更新日期：2006-11-01 00:00:00

abstract：:Memories for daily events require that individuals integrate initial fragile traces of events over time. Recent evidence suggests that reward anticipation enhances memory performance and amplifies frontal theta activity for remembered items vs. forgotten items. However, little is known about how incidental rewards aft...

journal_title：Neurobiology of learning and memory

authors： Pu M,Yu R

更新日期：2019-02-01 00:00:00

abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

journal_title：Neurobiology of learning and memory

authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

更新日期：2016-01-01 00:00:00

abstract：:The use of visual habituation in the study of infant cognition and learning is reviewed. This article traces the history of the technique, underlying theory, and procedural variation in its measurement. In addition, we review empirical findings with respect to the cognitive processes that presumably contribute to habi...

journal_title：Neurobiology of learning and memory

authors： Colombo J,Mitchell DW

更新日期：2009-09-01 00:00:00

abstract：:Physical exercise can improve cognitive functions and promote learning and memory, especially when performed in close temporal proximity to the encoding of information. This benefit may occur due to circulating stress hormones released in response to acute exercise. When administered after encoding, acute stress typic...

journal_title：Neurobiology of learning and memory

authors： Jentsch VL,Wolf OT

更新日期：2020-09-01 00:00:00

abstract：:Effects of estradiol benzoate (EB), ERα-selective agonist, propyl pyrazole triol (PPT) and ERβ-selective agonists, diarylpropionitrile (DPN) and Compound 19 (C-19) on memory were investigated in OVX rats using object recognition (OR) and placement (OP) memory tasks. Treatments were acute (behavior 4h later) or sub chr...

journal_title：Neurobiology of learning and memory

authors： Jacome LF,Gautreaux C,Inagaki T,Mohan G,Alves S,Lubbers LS,Luine V

更新日期：2010-11-01 00:00:00

abstract：:Regional differences in large-scale connectivity have been proposed to underlie functional specialization along the anterior-posterior axis of the medial temporal lobe (MTL), including the hippocampus (HC) and the parahippocampal gyrus (PHG). However, it is unknown whether functional connectivity (FC) can be used reli...

journal_title：Neurobiology of learning and memory

authors： Wang SF,Ritchey M,Libby LA,Ranganath C

更新日期：2016-10-01 00:00:00

abstract：:Androgens can have performance-enhancing effects in some cognitive tasks, but the mechanism of these effects has not been established. Experiments examined whether androgens' actions to bind to intracellular androgen receptors (ARs) in the hippocampus are necessary to enhance cognitive performance in the inhibitory av...

journal_title：Neurobiology of learning and memory

authors： Edinger KL,Frye CA

更新日期：2007-02-01 00:00:00

abstract：:Molecular genetic manipulation of the mouse offers the possibility of elucidating the function of individual gene products in neural systems underlying learning and memory. Many extant learning paradigms for mice rely on negative reinforcement, involve simple problems that are relatively rapidly acquired and thus prec...

journal_title：Neurobiology of learning and memory

authors： Brooks AI,Cory-Slechta DA,Murg SL,Federoff HJ

更新日期：2000-11-01 00:00:00

abstract：:Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial for restoring cognitive abilities in individuals with DS. Attention...

journal_title：Neurobiology of learning and memory

authors： Heller HC,Salehi A,Chuluun B,Das D,Lin B,Moghadam S,Garner CC,Colas D

更新日期：2014-12-01 00:00:00

abstract：:The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...

journal_title：Neurobiology of learning and memory

authors： Quartermain D,Garcia deSoria V

更新日期：2001-07-01 00:00:00

abstract：:Whether or not spatial memories reorganize in the rodent brain is an unanswered question that carries the importance of whether the rodent provides a suitable animal model of human retrograde amnesia. The finding of equally impaired recent and remote spatial memory could reflect the continued importance of the hippoca...

journal_title：Neurobiology of learning and memory

authors： Hales JB,Ocampo AC,Broadbent NJ,Clark RE

更新日期：2016-12-01 00:00:00

abstract：:Recently developed neuroimaging and electrophysiological techniques are allowing us to answer fundamental questions about how behavioral states regulate our perception of the external environment. Studies using these techniques have yielded surprising insights into how sensory processing is affected at the earliest st...

journal_title：Neurobiology of learning and memory

authors： Aton SJ

更新日期：2013-11-01 00:00:00

abstract：:Studies in rodents have demonstrated that glucocorticoids enhance memory consolidation but impair delayed memory retrieval. Similar findings have been reported in humans. Emotional items are better remembered than neutral items. However, it is unknown if emotional valence influences the effects of cortisol on retrieva...

journal_title：Neurobiology of learning and memory

authors： Kuhlmann S,Kirschbaum C,Wolf OT

更新日期：2005-03-01 00:00:00

abstract：:Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. ...

journal_title：Neurobiology of learning and memory

authors： von Leden RE,Curley LC,Greenberg GD,Hunsaker MR,Willemsen R,Berman RF

更新日期：2014-03-01 00:00:00

abstract：:Over the last decade, the interest in transcranial direct current stimulation (tDCS) has continued to increase, along with consideration of how it affects neuroplasticity mechanisms in the brain. Both human and animal studies have demonstrated numerous benefits and, although its application has increased, the neurophy...

journal_title：Neurobiology of learning and memory

authors： Stafford J,Brownlow ML,Qualley A,Jankord R

更新日期：2018-04-01 00:00:00

abstract：:Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Here we show that if Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, which at either site alone are insuff...

journal_title：Neurobiology of learning and memory

authors： Sherff CM,Carew TJ

更新日期：2002-11-01 00:00:00

abstract：:Most long-term memories are forgotten, becoming progressively less likely to be recalled. Still, some memory fragments may persist, as savings memory (easier relearning) can be detected long after recall has become impossible. What happens to a memory trace during forgetting that makes it inaccessible for recall and y...

journal_title：Neurobiology of learning and memory

authors： Patel U,Perez L,Farrell S,Steck D,Jacob A,Rosiles T,Krause E,Nguyen M,Calin-Jageman RJ,Calin-Jageman IE

更新日期：2018-11-01 00:00:00

abstract：:Formation of long-term memories requires coordinated gene expression, which can be regulated at transcriptional, post-transcriptional, and translational levels. Post-transcriptional stabilization and destabilization of mRNAs provides precise temporal and spatial regulation of gene expression, which is critical for con...

journal_title：Neurobiology of learning and memory

authors： Lee YS,Lee JA,Kaang BK

更新日期：2015-10-01 00:00:00

abstract：:The study of bidirectional conditioning began more than a century ago, yet it has failed to take strong root in psychology and neuroscience. We revisit this topic by exploiting E. A. Asratyan's alternating procedure of stimulus presentation, in which both forward (e.g., A → B) and backward (e.g., B → A) training trial...

journal_title：Neurobiology of learning and memory

authors： Navarro VM,Wasserman EA

更新日期：2020-05-01 00:00:00

abstract：:Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...

journal_title：Neurobiology of learning and memory

authors： Buttigieg A,Flores O,Hernández A,Sáez-Briones P,Burgos H,Morgan C

更新日期：2014-01-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:Intellectual disability is a common feature in genetic disorders with enhanced RAS-ERK1/2 signaling, including neurofibromatosis type 1 (NF1) and Noonan syndrome (NS). Additional training trials and additional spacing between trials, respectively, restores memory deficits in animal models of NF1 and NS. However, the r...

journal_title：Neurobiology of learning and memory

authors： Cattaneo V,San Martin A,Lew SE,Gelb BD,Pagani MR

更新日期：2020-07-01 00:00:00

abstract：:It has been well established that moderate physiological or emotional arousal modulates memory. However, there is some controversy about whether the source of arousal must be semantically related to the information to be remembered. To test this idea, 35 healthy young adult participants learned a list of common nouns ...

journal_title：Neurobiology of learning and memory

authors： Nielson KA,Yee D,Erickson KI

更新日期：2005-07-01 00:00:00

abstract：:The purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, Extracellular signal-Regulated Kinase (ERK) and Mammalian Target of Rapamycin (mTOR) pathways in the development of short and long term memories during the acquisition and recall of the step-down inhibitory ...

journal_title：Neurobiology of learning and memory

authors： Giovannini MG,Lana D,Pepeu G

更新日期：2015-03-01 00:00:00

abstract：:Neuronal plasticity and neurogenesis occur in the adult hippocampus and in other brain structures such as the olfactory bulb and often involve the neural cell adhesion molecule NCAM. During an olfactory associative discrimination learning task, NCAM polysialylation triggers neuronal plasticity in the adult hippocampus...

journal_title：Neurobiology of learning and memory

authors： Mione J,Manrique C,Duhoo Y,Roman FS,Guiraudie-Capraz G

更新日期：2016-04-01 00:00:00

abstract：:Although everyone would agree that successful translation of therapeutic candidates for central nervous disorders should involve non-human primate (nhp) models of cognitive disorders, we are left with the paucity of publications reporting either the target validation or the actual preclinical testing in heuristic nhp ...

journal_title：Neurobiology of learning and memory

authors： Camus S,Ko WK,Pioli E,Bezard E

更新日期：2015-10-01 00:00:00

abstract：:We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on h...

journal_title：Neurobiology of learning and memory

authors： Van der Jeugd A,Ahmed T,Burnouf S,Belarbi K,Hamdame M,Grosjean ME,Humez S,Balschun D,Blum D,Buée L,D'Hooge R

更新日期：2011-03-01 00:00:00

abstract：:Research has shown that a single presentation of the conditioned stimulus prior to extinction training can diminish conditioned responses. However, replication has proven difficult and appears to be limited by boundary conditions. Here we tested the boundary condition of memory strength by comparing the effect of rein...

journal_title：Neurobiology of learning and memory

authors： Kitamura H,Johnston P,Johnson L,Strodl E

更新日期：2020-10-01 00:00:00