Abstract:
:Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. Fmrp, Arc, and c-Fos protein levels were quantified by Western blot in the contralateral motor cortex of mice following training to reach for sucrose pellets with a non-preferred paw and compared to levels in the ipsilateral motor cortex. After training, all mice showed increases in Fmrp, Arc, and c-Fos protein levels in the contralateral compared to the ipsilateral hemisphere; however, the increase in CGG KI mice was less than wildtype mice. Increases in Fmrp and Arc proteins scaled with learning, whereas this relationship was not observed with the c-Fos levels. These data suggest the possibility that reduced levels of activity-dependent proteins associated with synaptic plasticity such as Fmrp and Arc may contribute to the neurocognitive phenotype reported in the CGG KI mice and the fragile X premutation.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
von Leden RE,Curley LC,Greenberg GD,Hunsaker MR,Willemsen R,Berman RFdoi
10.1016/j.nlm.2014.01.011subject
Has Abstractpub_date
2014-03-01 00:00:00pages
160-8eissn
1074-7427issn
1095-9564pii
S1074-7427(14)00012-4journal_volume
109pub_type
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