Abstract：
:The hippocampus is important for memory and learning, being a brain site where initial memories are formed and where sharp wave - ripples (SWR) are found, which are responsible for mapping recent memories to long-term storage during sleep-related memory replay. While this conceptual schema is well established, specific intrinsic and network-level mechanisms driving spatio-temporal patterns of hippocampal activity during sleep, and specifically controlling off-line memory reactivation are unknown. In this study, we discuss a model of hippocampal CA1-CA3 network generating spontaneous characteristic SWR activity. Our study predicts the properties of CA3 input which are necessary for successful CA1 ripple generation and the role of synaptic interactions and intrinsic excitability in spike sequence replay during SWRs. Specifically, we found that excitatory synaptic connections promote reactivation in both CA3 and CA1, but the different dynamics of sharp waves in CA3 and ripples in CA1 result in a differential role for synaptic inhibition in modulating replay: promoting spike sequence specificity in CA3 but not in CA1 areas. Finally, we describe how awake learning of spatial trajectories leads to synaptic changes sufficient to drive hippocampal cells' reactivation during sleep, as required for sleep-related memory consolidation.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Malerba P,Bazhenov Mdoi
10.1016/j.nlm.2018.04.018subject
Has Abstractpub_date
2019-04-01 00:00:00pages
98-107eissn
1074-7427issn
1095-9564pii
S1074-7427(18)30103-5journal_volume
160pub_type
杂志文章abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2021.107384
更新日期：2021-01-15 00:00:00
abstract：:The activation of cAMP response element-binding protein (CREB) after a learning experience is a common feature in the formation of several associative memories. We recently demonstrated that the increase in the hippocampal phosphorylated CREB (pCREB) levels 1 h after a short exploration of an open field (OF) was assoc...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2005.12.002
更新日期：2006-07-01 00:00:00
abstract：:Pre-test exposure to training-related cues is known to improve subsequent retention performance. To identify brain regions engaged in processes promoted by retrieval cues, a brain imaging approach using the [6-14C]glucose autoradiographic technique was used. Sprague-Dawley rats trained in a brightness discrimination a...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/s1074-7427(02)00010-2
更新日期：2003-01-01 00:00:00
abstract：:Drug addiction can be understood as a pathological subversion of normal brain learning and memory processes strengthened by the motivational impact of drug-associated stimuli, leading to the establishment of compulsive drug-seeking habits. Such habits evolve through a cascade of complex associative processes with Pavl...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.2002.4103
更新日期：2002-11-01 00:00:00
abstract：:The purpose of this review is to summarize the present knowledge on the interplay among the cholinergic system, Extracellular signal-Regulated Kinase (ERK) and Mammalian Target of Rapamycin (mTOR) pathways in the development of short and long term memories during the acquisition and recall of the step-down inhibitory ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2014.12.014
更新日期：2015-03-01 00:00:00
abstract：:This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.10.008
更新日期：2009-03-01 00:00:00
abstract：:The neurophysiological basis for context conditioning is conceptually problematic because neurophysiological descriptions of activity-dependent (associative) forms of neuronal plasticity uniformly assume that a specific temporal relationship between signals is necessary for memory induction. In the present experiments...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.1998.3890
更新日期：1999-09-01 00:00:00
abstract：:Primary sensory cortical fields develop highly specific associative representational plasticity, notably enlarged area of representation of reinforced signal stimuli within their topographic maps. However, overtraining subjects after they have solved an instrumental task can reduce or eliminate the expansion while the...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2015.10.006
更新日期：2015-12-01 00:00:00
abstract：:This article argues both rapid eye movement (REM) and non-rapid eye movement (NREM) sleep contribute to overnight episodic memory processes but their roles differ. Episodic memory may have evolved from memory for spatial navigation in animals and humans. Equally, mnemonic navigation in world and mental space may rely ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2015.04.005
更新日期：2015-07-01 00:00:00
abstract：:Nicotine has been demonstrated to enhance learning processes. The present experiments extend these results to examine the effects of nicotine on acquisition and consolidation of contextual and cued fear conditioning, and the duration of nicotine's enhancement of conditioned fear. C57BL/6 mice were trained with two pai...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/s1074-7427(03)00057-1
更新日期：2003-09-01 00:00:00
abstract：:The current review provides a historical perspective on the evolution of hypothesized mechanisms for senescent neurophysiology, focused on the CA1 region of the hippocampus, and the relationship of senescent neurophysiology to impaired hippocampal-dependent memory. Senescent neurophysiology involves processes linked t...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2019.107064
更新日期：2019-10-01 00:00:00
abstract：:An increasing number of studies using human subjects substantiate the use of transcranial direct current stimulation (tDCS) as a noninvasive approach to treat various neurological symptoms. tDCS has been tested in conditions from motor to cognition dysfunctions. Performance enhancement of healthy subjects using tDCS h...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.107126
更新日期：2020-01-01 00:00:00
abstract：:Medial thalamic damage is a common cause of severe memory disruption in humans. Both the anterior thalamic nuclei (ATN) and the intralaminar thalamic nuclei (ILN) have been suggested as primary sites of diencephalic injury underlying learning and memory deficits, but their respective roles have yet to be resolved. The...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2008.01.007
更新日期：2008-07-01 00:00:00
abstract：:MeCP2 is required both during postnatal neurodevelopment and throughout the adult life for brain function. Although it is well accepted that MeCP2 in the maturing nervous system is critical for establishing normal development, the functions of MeCP2 during adulthood are poorly understood. Particularly, the requirement...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.02.010
更新日期：2018-03-01 00:00:00
abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2014.11.002
更新日期：2015-02-01 00:00:00
abstract：:The hippocampus is heavily involved in the learning and memory processes necessary to successfully encode environmental stimuli and representations over time. Impairment of hippocampal function is associated with numerous neuropsychiatric diseases and can lead to detriments in the quality of life. In order to take ful...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2015.08.002
更新日期：2015-11-01 00:00:00
abstract：:The amygdala, medial hypothalamus, dorsal periaqueductal gray (dPAG), superior and inferior colliculus together constitutes the encephalic aversion system which has been considered the main neural substrate for the integration of unconditioned aversive behavioral states. Within the amygdala the basolateral nucleus (BL...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2013.03.004
更新日期：2013-05-01 00:00:00
abstract：:Human episodic memory refers to the recollection of an unique past experience in terms of what happened, and where and when it happened. Factoring out the issue of conscious recollection, episodic memory, even at the behavioral level, has been difficult to demonstrate in non-human mammals. Although, it was previously ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2005.07.002
更新日期：2005-11-01 00:00:00
abstract：:It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or drug-related behaviors, they have not been ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.11.003
更新日期：2013-02-01 00:00:00
abstract：:Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g., visuospatial interference tasks, like Tetris) have been shown to be effective at disrupting reactivated memory. In the present study, participants created a memory ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2018.11.003
更新日期：2018-12-01 00:00:00
abstract：:Temporal lobe epilepsy patients have demonstrated a relative preservation in the integrity of implicit memory procedures. We examined performance in a verbal implicit and explicit memory task in left anterior temporal lobectomy patients (LATL) and healthy normal controls (NCs) while undergoing fMRI. We hypothesized th...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.08.005
更新日期：2012-10-01 00:00:00
abstract：:Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of re...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章,评审
doi：10.1016/j.nlm.2018.04.004
更新日期：2019-04-01 00:00:00
abstract：:Corticosterone (CORT), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion CA3. We tested the hypothesis that CORT would impair spatial memory, a hippocampal function. In each of the three experiments, rats received daily, subcutaneous injections of either CORT (26.8 mg/kg bod...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/s1074-7427(03)00019-4
更新日期：2003-07-01 00:00:00
abstract：:This experiment tests the hypothesis that the cholinergic nucleus basalis magnocellularis (NBM) is necessary for complex or configural association learning, but not elemental or simple association learning. Male Long-Evans rats with bilateral 192 IgG-saporin lesions of the NBM (n = 12) and sham-operated controls (n = ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1006/nlme.2001.4013
更新日期：2002-03-01 00:00:00
abstract：:It is widely accepted that unitization can promote familiarity-based associative recognition, but the role of unitization in recognition of individual component elements which originate from compound words remains unclear. The goals of this study were to elaborate on how unitization affects item recognition and furthe...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2019.107130
更新日期：2020-01-01 00:00:00
abstract：:When placed in a novel environment, mice tend to explore for a period of time, and then reduce the level of exploration. This reduction in locomotor or exploratory behavior is known as habituation and can occur within a single session or across sessions, respectively, termed intrasession and intersession habituation. ...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2009.02.002
更新日期：2009-09-01 00:00:00
abstract：:We previously identified a set of 50 genes that were differentially transcribed in the hippocampal CA1 region of aged, learning-impaired rats compared to aged, superior learning animals during a Morris water maze paradigm. In the current study, we expressed three of these genes (Pctk1, Tcf12 and Ccnd1), which had show...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2011.09.006
更新日期：2012-01-01 00:00:00
abstract：:Chronic stress leads to a dysregulated inhibitory tone that could impact hippocampal-dependent spatial learning and memory. The present study examined whether spatial memory deficits resulting from chronic stress could be overcome by antagonizing the GABAA receptor, a prominent inhibitory receptor of GABA in the hippo...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2017.09.002
更新日期：2017-11-01 00:00:00
abstract：:Early life adverse events can lead to structural and functional impairments in the prefrontal cortex (PFC). Here, we investigated whether maternal deprivation (MD) alters PFC-dependent executive functions, neurons and astrocytes number and synaptic plasticity in adult male Long-Evans rats. The deprivation protocol con...
journal_title：Neurobiology of learning and memory
pub_type： 杂志文章
doi：10.1016/j.nlm.2012.08.004
更新日期：2012-10-01 00:00:00
abstract：:One of the major achievements of the last century of research in experimental psychology is the identification of a coherent set of theories and principles to characterize the nature of simple forms of associative learning. Major advances are also currently being made at a rapid pace in the neurobiology of associative...
journal_title：Neurobiology of learning and memory
pub_type： 社论
doi：10.1016/j.nlm.2013.12.006
更新日期：2014-02-01 00:00:00
