当前位置： SCI文献检索 > NEUROBIOLOGY OF LEARNING AND MEMORY期刊下所有文献 > Loss of hippocampal function impairs pattern separation on a mouse touch-screen operant paradigm.

Loss of hippocampal function impairs pattern separation on a mouse touch-screen operant paradigm.

Abstract：

:The hippocampus is heavily involved in the learning and memory processes necessary to successfully encode environmental stimuli and representations over time. Impairment of hippocampal function is associated with numerous neuropsychiatric diseases and can lead to detriments in the quality of life. In order to take full advantage of preclinical models of these disorders, there is a need for the development of more refined measures of clinically relevant hippocampal behaviors. While arena-based navigation tasks have provided fundamental information regarding the role of the hippocampus in spatial memory, the development of automated operant variants have had mixed results. Recently, an automated touch-screen paradigm has been shown to be highly sensitive to hippocampal function in the rat and eliminated mediating strategies that arose in previous tasks. Here we show that mice with lesions encompassing the entire ventral portion of the dorsal hippocampus are impaired on pattern separation behavior using a delayed nonmatching-to-location (TUNL) adapted for mice. Lesioned mice readily acquired the task at control rates when separations were maximal and delay periods were short while decreasing separations significantly impaired lesion mice. However, in contrast to previously reported results in the rat, consistently increasing delays did not significantly impair performance in the lesion group. Presentation of a variable delay within a session significantly impaired performance in lesion mice across delay periods. The current results demonstrate the utility of a touch-screen paradigm for measuring hippocampal-dependent pattern separation in the mouse and establish the paradigm as an important platform for future studies in disease models.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Josey M,Brigman JL

doi

10.1016/j.nlm.2015.08.002

subject

Has Abstract

pub_date

2015-11-01 00:00:00

pages

85-92

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(15)00150-1

journal_volume

125

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF LEARNING AND MEMORY文献大全
  • Exposure to a retrieval cue in rats induces changes in regional brain glucose metabolism in the amygdala and other related brain structures.

    abstract：:Pre-test exposure to training-related cues is known to improve subsequent retention performance. To identify brain regions engaged in processes promoted by retrieval cues, a brain imaging approach using the [6-14C]glucose autoradiographic technique was used. Sprague-Dawley rats trained in a brightness discrimination a...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/s1074-7427(02)00010-2

    authors： Boujabit M,Bontempi B,Destrade C,Gisquet-Verrier P

    更新日期：2003-01-01 00:00:00

  • Alcohol-related amnesia and dementia: animal models have revealed the contributions of different etiological factors on neuropathology, neurochemical dysfunction and cognitive impairment.

    abstract：:Chronic alcoholism is associated with impaired cognitive functioning. Over 75% of autopsied chronic alcoholics have significant brain damage and over 50% of detoxified alcoholics display some degree of learning and memory impairment. However, the relative contributions of different etiological factors to the developme...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2011.01.003

    authors： Vetreno RP,Hall JM,Savage LM

    更新日期：2011-11-01 00:00:00

  • Both electrolytic and excitotoxic lesions of nucleus accumbens disrupt latent inhibition of learning in rats.

    abstract：:Evidence indicating a role for the nucleus accumbens in the development of latent inhibition of learning has accumulated. Two experiments were conducted using Wistar rats to investigate this role directly. Experiment 1 used a conditioned emotional response paradigm to assess the effects of discrete electrolytic lesion...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1995.1042

    authors： Tai CT,Cassaday HJ,Feldon J,Rawlins JN

    更新日期：1995-07-01 00:00:00

  • Reduced activity-dependent protein levels in a mouse model of the fragile X premutation.

    abstract：:Environmental enrichment results in increased levels of Fmrp in brain and increased dendritic complexity. The present experiment evaluated activity-dependent increases in Fmrp levels in the motor cortex in response to training on a skilled forelimb reaching task in the CGG KI mouse model of the fragile X premutation. ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.01.011

    authors： von Leden RE,Curley LC,Greenberg GD,Hunsaker MR,Willemsen R,Berman RF

    更新日期：2014-03-01 00:00:00

  • Multiple memory systems as substrates for multiple decision systems.

    abstract：:It has recently become widely appreciated that value-based decision making is supported by multiple computational strategies. In particular, animal and human behavior in learning tasks appears to include habitual responses described by prominent model-free reinforcement learning (RL) theories, but also more deliberati...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.04.014

    authors： Doll BB,Shohamy D,Daw ND

    更新日期：2015-01-01 00:00:00

  • Daytime napping: Effects on human direct associative and relational memory.

    abstract：:Sleep facilitates declarative memory processing. However, we know little about whether sleep plays a role in the processing of a fundamental feature of declarative memory, relational memory - the flexible representation of items not directly learned prior to sleep. Thirty-one healthy participants first learned at 12 p...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.nlm.2010.02.003

    authors： Lau H,Tucker MA,Fishbein W

    更新日期：2010-05-01 00:00:00

  • The effect of amygdala lesions on conditional and unconditional vocalizations in rats.

    abstract：:Electrolytic lesions centered on the amygdaloid central nucleus (ACe) resulted in the inability of rats to acquire a Pavlovian conditional vocalization response. Conditioning consisted of pairing a light conditional stimulus with a tailshock unconditional stimulus (US). The thresholds of three unconditional responses ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/s1074-7427(03)00002-9

    authors： Borszcz GS,Leaton RN

    更新日期：2003-05-01 00:00:00

  • Boundary conditions of post-retrieval extinction: A direct comparison of low and high partial reinforcement.

    abstract：:Research has shown that a single presentation of the conditioned stimulus prior to extinction training can diminish conditioned responses. However, replication has proven difficult and appears to be limited by boundary conditions. Here we tested the boundary condition of memory strength by comparing the effect of rein...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2020.107285

    authors： Kitamura H,Johnston P,Johnson L,Strodl E

    更新日期：2020-10-01 00:00:00

  • Maternal deprivation induces deficits in temporal memory and cognitive flexibility and exaggerates synaptic plasticity in the rat medial prefrontal cortex.

    abstract：:Early life adverse events can lead to structural and functional impairments in the prefrontal cortex (PFC). Here, we investigated whether maternal deprivation (MD) alters PFC-dependent executive functions, neurons and astrocytes number and synaptic plasticity in adult male Long-Evans rats. The deprivation protocol con...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2012.08.004

    authors： Baudin A,Blot K,Verney C,Estevez L,Santamaria J,Gressens P,Giros B,Otani S,Daugé V,Naudon L

    更新日期：2012-10-01 00:00:00

  • Effects of a flavor-placement reversal test after different modalities of taste aversion learning.

    abstract：:Taste aversion learning is induced through two different behavioral procedures: a short-term or concurrent (two-daily flavors) and a long-term or sequential (one-daily flavor) procedure. For the concurrent group of animals, two gustatory/olfactory stimuli are presented separately but at the same time on a daily basis....

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2000.3990

    authors： Mediavilla C,Molina F,Puerto A

    更新日期：2001-09-01 00:00:00

  • The effects of selective cholinergic basal forebrain lesions and aging upon expectancy in the rat.

    abstract：:The effects of selective cholinergic cell loss within the basal forebrain (BF) were determined using a task that requires shifting of attention between two visual stimuli. Discriminability between two stimuli and response bias were determined in young and old F-344 rats given BF injections of IgG-192 saporin (100 ng)....

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1997.3768

    authors： Stoehr JD,Mobley SL,Roice D,Brooks R,Baker LM,Wiley RG,Wenk GL

    更新日期：1997-05-01 00:00:00

  • Impaired long-term potentiation and enhanced neuronal excitability in the amygdala of Ca(V)1.3 knockout mice.

    abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2009.06.012

    authors： McKinney BC,Sze W,Lee B,Murphy GG

    更新日期：2009-11-01 00:00:00

  • 2D:4D and spatial abilities: From rats to humans.

    abstract：:Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and waterm...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.04.012

    authors： Müller N,Campbell S,Nonaka M,Rost TM,Pipa G,Konrad BN,Steiger A,Czisch M,Fernández G,Dresler M,Genzel L

    更新日期：2018-05-01 00:00:00

  • Relational memory generalization and integration in a transitive inference task with and without instructed awareness.

    abstract：:Two experiments investigated the potential facilitative effects of prior instructed awareness and predetermined learning criteria on humans' ability to make transitive inference (TI) judgments. Participants were first exposed to a learning phase and required to learn five premise pairs (A+B-, B+C-, C+D-, D+E-, E+F-). ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.01.004

    authors： Munnelly A,Dymond S

    更新日期：2014-03-01 00:00:00

  • Intrasession and intersession habituation in mice: from inbred strain variability to linkage analysis.

    abstract：:When placed in a novel environment, mice tend to explore for a period of time, and then reduce the level of exploration. This reduction in locomotor or exploratory behavior is known as habituation and can occur within a single session or across sessions, respectively, termed intrasession and intersession habituation. ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2009.02.002

    authors： Bolivar VJ

    更新日期：2009-09-01 00:00:00

  • The critical role of cholinergic basal forebrain neurons in morphological change and memory encoding: a hypothesis.

    abstract：:It has been known for a long time that cholinergic basal forebrain neurons which project to the cerebral cortex play a role in learning and memory. Behavioral studies following lesions, for example, repeatedly have suggested multiple learning-related roles for these neurons. Apart from behavioral studies, cholinergic ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0068

    authors： Woolf NJ

    更新日期：1996-11-01 00:00:00

  • Latent inhibition in conditioned taste aversion: the roles of stimulus frequency and duration and the amount of fluid ingested during preexposure.

    abstract：:Two experiments examined the effects of total stimulus preexposure on latent inhibition (LI) in a conditioned taste aversion procedure with rats. Experiment 1 varied the frequency and duration of saccharin preexposures. LI was an increasing function of the product of frequency x duration. Experiment 2 kept saccharin e...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1995.1051

    authors： De la Casa G,Lubow RE

    更新日期：1995-09-01 00:00:00

  • Fetal alcohol-exposed rats exhibit differential response to cholinergic drugs on a delay-dependent memory task.

    abstract：:Fetal alcohol exposure in human and rodents produces a number of cognitive deficits including impairments in learning and memory. Recent evidence in our laboratory has shown that fetal alcohol-exposed (FAE) rats respond differently to systemic administration of cholinergic drugs when tested for vigilance and locomotor...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1999.3909

    authors： Nagahara AH,Handa RJ

    更新日期：1999-11-01 00:00:00

  • Micro- and macrostructure of learning in active avoidance: a quantitative approach.

    abstract：:The dynamics of learning in the Active Avoidance test was analyzed at the trials level as well as at the level of daily sessions, each comprising numerous trials. The two scales (large scale for the sessions and small scale for the trials) were demonstrated to be mutually independent. The intermediate derived scales (...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0009

    authors： Giuliani A,Mancini AM,Ghirardi O,Ramacci MT,Voronina T,Sirabella P,Colosimo A

    更新日期：1996-01-01 00:00:00

  • Enhanced neuronal excitability in rat CA1 pyramidal neurons following trace eyeblink conditioning acquisition is not due to alterations in I M.

    abstract：:Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.07.002

    authors： Kuo AG,Lee G,McKay BM,Disterhoft JF

    更新日期：2008-02-01 00:00:00

  • The role of glucocorticoids, catecholamines and endocannabinoids in the development of traumatic memories and posttraumatic stress symptoms in survivors of critical illness.

    abstract：:Critically ill patients are at an increased risk for traumatic memories and post-traumatic stress disorder (PTSD). Memories of one or more traumatic events play an important part in the symptom pattern of PTSD. Studies in long-term survivors of intensive care unit (ICU) treatment demonstrated a clear and vivid recall ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2013.10.003

    authors： Hauer D,Kaufmann I,Strewe C,Briegel I,Campolongo P,Schelling G

    更新日期：2014-07-01 00:00:00

  • Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation.

    abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.04.009

    authors： Collins BE,Sweatt JD,Greer CB

    更新日期：2019-05-01 00:00:00

  • The medial prefrontal cortex and memory of cue location in the rat.

    abstract：:We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoid...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2009.09.003

    authors： Rawson T,O'Kane M,Talk A

    更新日期：2010-01-01 00:00:00

  • Positive and negative sources of emotional arousal enhance long-term word-list retention when induced as long as 30 min after learning.

    abstract：:The consolidation of newly formed memories occurs slowly, allowing memories to be altered by experience for some time after their formation. Various treatments, including arousal, can modulate memory consolidation when given soon after learning, but the degree of time-dependency of these treatments in humans has not b...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.03.005

    authors： Nielson KA,Powless M

    更新日期：2007-07-01 00:00:00

  • Chronic high-frequency repetitive transcranial magnetic stimulation improves age-related cognitive impairment in parallel with alterations in neuronal excitability and the voltage-dependent Ca2+ current in female mice.

    abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.11.002

    authors： Wang HL,Xian XH,Wang YY,Geng Y,Han B,Wang MW,Li WB

    更新日期：2015-02-01 00:00:00

  • Weak involvement of octopamine in aversive taste learning in a snail.

    abstract：:The pond snail Lymnaea stagnalis is capable of learning taste aversion by pairing presentations of a sucrose solution and an electric shock and consolidating it into long-term memory (LTM), which is referred to as conditioned taste aversion (CTA). We asked here if the neurotransmitter octopamine is involved in CTA. We...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.04.010

    authors： Aonuma H,Kaneda M,Hatakeyama D,Watanabe T,Lukowiak K,Ito E

    更新日期：2017-05-01 00:00:00

  • Effects of postoperative housing conditions on functional recovery in rats with lesions of the hippocampus, subiculum, or entorhinal cortex.

    abstract：:In order to study the effects of differential housing conditions on recovery from damage to different components of the hippocampal formation, 85 rats received bilateral lesions of the hippocampus, entorhinal cortex, or subiculum or sham surgery and then were housed for 30 days in either an enriched environment or an ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.3745

    authors： Galani R,Jarrard LE,Will BE,Kelche C

    更新日期：1997-01-01 00:00:00

  • Developmental emergence of long-term memory for sensitization in Aplysia.

    abstract：:Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.0031

    authors： Wright WG,McCance EF,Carew TJ

    更新日期：1996-05-01 00:00:00

  • Spatial learning in the holeboard impairs an early phase of long-term potentiation in the rat hippocampal CA1-region.

    abstract：:Long-term potentiation (LTP) and depression (LTD) are considered as cellular models for learning and memory. We studied the impact of holeboard training on LTP in the rat CA1 hippocampal region. In 7-week-old Wistar rats a recording electrode was chronically implanted into the hippocampal pyramidal cell layer of the C...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2007.11.003

    authors： Makhracheva-Stepochkina D,Frey S,Frey JU,Korz V

    更新日期：2008-05-01 00:00:00

  • Diversity of mnemonic function within the entorhinal cortex: a meta-analysis of rodent behavioral studies.

    abstract：:The entorhinal cortex (EC) has been shown to be an integral piece of the hippocampal memory system. It sits in a unique position within the brain with strong, intricate, reciprocal connectivity with the hippocampus as well as a vast array of neocortical regions. Topographical patterns of afferent and efferent projecti...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.nlm.2014.08.006

    authors： Morrissey MD,Takehara-Nishiuchi K

    更新日期：2014-11-01 00:00:00