The critical role of cholinergic basal forebrain neurons in morphological change and memory encoding: a hypothesis.

abstract：:The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lo...

journal_title：Neurobiology of learning and memory

authors： Freeman FM,Young IG

更新日期：2001-05-01 00:00:00

abstract：:This study was designed to examine the effect of corticosterone on consolidation of contextual fear memory and hippocampal long-term potentiation (LTP) in rats. In Experiment 1, dose-response effects of corticosterone on consolidation of contextual fear memory were determined. Immediately after training in contextual ...

journal_title：Neurobiology of learning and memory

authors： Abrari K,Rashidy-Pour A,Semnanian S,Fathollahi Y,Jadid M

更新日期：2009-03-01 00:00:00

abstract：:Drug abuse, overeating, and smoking are all examples of instrumental behaviors that often involve chains or sequences of behavior. A behavior chain is minimally composed of a procurement response that is required in order for a subsequent consumption response to be reinforced. Despite the translational importance of b...

journal_title：Neurobiology of learning and memory

authors： Thrailkill EA,Bouton ME

更新日期：2016-09-01 00:00:00

abstract：:Much has been said about how significant life events modulate our response to stimuli that are integral to those events. However, we know less about the more general consequences of these events, that is, how they affect subsequent learning abilities that are seemingly irrelevant to the initial event. Here, it is prop...

journal_title：Neurobiology of learning and memory

authors： Shors TJ

更新日期：2006-03-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need f...

journal_title：Neurobiology of learning and memory

authors： Shafia S,Vafaei AA,Samaei SA,Bandegi AR,Rafiei A,Valadan R,Hosseini-Khah Z,Mohammadkhani R,Rashidy-Pour A

更新日期：2017-03-01 00:00:00

abstract：:Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as 'incubation of craving'. As adolescence...

journal_title：Neurobiology of learning and memory

authors： Madsen HB,Zbukvic IC,Luikinga SJ,Lawrence AJ,Kim JH

更新日期：2017-09-01 00:00:00

abstract：:The authors evaluate a mapping of Rescorla and Wagner's (1972) behavioral model of classical conditioning onto the cerebellar substrates for motor reflex learning and illustrate how the limitations of the Rescorla-Wagner model are just as useful as its successes for guiding the development of new psychobiological theo...

journal_title：Neurobiology of learning and memory

authors： Gluck MA,Allen MT,Myers CE,Thompson RF

更新日期：2001-11-01 00:00:00

abstract：:The present study examined the effects of posttraining ethanol administration upon retention of an appetitive task using a variety of retention behaviors associated with the task. Male C57BL/6J mice were individually trained to find a cheese pellet placed in the corner of an open field. Five behavioral measures were u...

journal_title：Neurobiology of learning and memory

authors： Ladner CJ,Babbini M,Davies DL,Parker ES,Alkana RL

更新日期：2001-01-01 00:00:00

abstract：:Previous studies showed that healthy young adults who spontaneously use caudate nucleus-dependent strategies on a virtual navigation task, have significantly lower basal levels of cortisol compared with adults who use hippocampus-dependent spatial navigation strategies. In the current paper, we assessed the relation b...

journal_title：Neurobiology of learning and memory

authors： Blanchette CA,Kurdi V,Fouquet C,Schachar R,Boivin M,Hastings P,Robaey P,West GL,Bohbot VD

更新日期：2020-03-01 00:00:00

abstract：:Mitogen-activated protein kinase (MAPK) is abundantly expressed in postmitotic neurons of the developed nervous system. MAPK is activated and required for induction of long-term potentiation (LTP) in the CA1 area of the hippocampus, which is blocked by the specific inhibitor of the MAPK kinase, PD 098059. Recently it ...

journal_title：Neurobiology of learning and memory

authors： Walz R,Roesler R,Quevedo J,Sant'Anna MK,Madruga M,Rodrigues C,Gottfried C,Medina JH,Izquierdo I

更新日期：2000-01-01 00:00:00

abstract：:Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...

journal_title：Neurobiology of learning and memory

authors： Wright WG,McCance EF,Carew TJ

更新日期：1996-05-01 00:00:00

abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...

journal_title：Neurobiology of learning and memory

authors： Wang HL,Xian XH,Wang YY,Geng Y,Han B,Wang MW,Li WB

更新日期：2015-02-01 00:00:00

abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Wong KL,Chavez CM,Leon MI,Robin KM,Weinberger NM

更新日期：2009-07-01 00:00:00

abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

journal_title：Neurobiology of learning and memory

authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

更新日期：2017-07-01 00:00:00

abstract：:It is unclear whether protein phosphatases, which counteract the actions of protein kinases, play a beneficial role in the formation and extinction of previously acquired fear memories. In this study, we investigated the role of the calcium/calmodulin dependent phosphatase 2B, also known as calcineurin (CaN) in the fo...

journal_title：Neurobiology of learning and memory

authors： Havekes R,Nijholt IM,Visser AK,Eisel UL,Van der Zee EA

更新日期：2008-05-01 00:00:00

abstract：:Chronic alcoholism is associated with impaired cognitive functioning. Over 75% of autopsied chronic alcoholics have significant brain damage and over 50% of detoxified alcoholics display some degree of learning and memory impairment. However, the relative contributions of different etiological factors to the developme...

journal_title：Neurobiology of learning and memory

authors： Vetreno RP,Hall JM,Savage LM

更新日期：2011-11-01 00:00:00

abstract：:The amygdala, medial hypothalamus, dorsal periaqueductal gray (dPAG), superior and inferior colliculus together constitutes the encephalic aversion system which has been considered the main neural substrate for the integration of unconditioned aversive behavioral states. Within the amygdala the basolateral nucleus (BL...

journal_title：Neurobiology of learning and memory

authors： Carvalho MC,Santos JM,Bassi GS,Brandão ML

更新日期：2013-05-01 00:00:00

abstract：:Adenosine, a purine ribonucleoside, exhibits neuromodulatory and neuroprotective effects in the brain and is involved in memory formation and cognitive function. Adenosine signaling is mediated by adenosine receptors (A1, A2A, A2B, and A3); in turn, nucleotide and nucleoside-metabolizing enzymes and adenosine transpor...

journal_title：Neurobiology of learning and memory

authors： Bortolotto JW,Melo GM,Cognato Gde P,Vianna MR,Bonan CD

更新日期：2015-02-01 00:00:00

abstract：:Physical exercise can improve cognitive functions and promote learning and memory, especially when performed in close temporal proximity to the encoding of information. This benefit may occur due to circulating stress hormones released in response to acute exercise. When administered after encoding, acute stress typic...

journal_title：Neurobiology of learning and memory

authors： Jentsch VL,Wolf OT

更新日期：2020-09-01 00:00:00

abstract：:Repeated exposure to an auditory stimulus leads to habituation of the electrophysiological and immediate-early-gene (IEG) expression response in the auditory system. A novel auditory stimulus reinstates this response in a form of dishabituation. This has been interpreted as the start of new memory formation for this n...

journal_title：Neurobiology of learning and memory

authors： Smulders TV,Jarvis ED

更新日期：2013-11-01 00:00:00

abstract：:Long-term potentiation (LTP) and depression (LTD) are considered as cellular models for learning and memory. We studied the impact of holeboard training on LTP in the rat CA1 hippocampal region. In 7-week-old Wistar rats a recording electrode was chronically implanted into the hippocampal pyramidal cell layer of the C...

journal_title：Neurobiology of learning and memory

authors： Makhracheva-Stepochkina D,Frey S,Frey JU,Korz V

更新日期：2008-05-01 00:00:00

abstract：:The hippocampus is important for memory and learning, being a brain site where initial memories are formed and where sharp wave - ripples (SWR) are found, which are responsible for mapping recent memories to long-term storage during sleep-related memory replay. While this conceptual schema is well established, specifi...

journal_title：Neurobiology of learning and memory

authors： Malerba P,Bazhenov M

更新日期：2019-04-01 00:00:00

abstract：:The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of whether intranasally applied pregnenolone (IN-PREG) also has promnestic properties in the rat. We examined the effects of IN-PREG at doses of 0.187 and 0.373mg/kg on memo...

journal_title：Neurobiology of learning and memory

authors： Abdel-Hafiz L,Chao OY,Huston JP,Nikolaus S,Spieler RE,de Souza Silva MA,Mattern C

更新日期：2016-09-01 00:00:00

abstract：:The recall of a previously formed fear memory triggers a process through which synapses in the amygdala become "destabilized". This labile state at retrieval may be critical for the plasticity required to modify, update, or disrupt long-term memories. One component of this process involves the rapid internalization of...

journal_title：Neurobiology of learning and memory

authors： Ferrara NC,Trask S,Pullins SE,Helmstetter FJ

更新日期：2019-12-01 00:00:00

abstract：:The impact of past history on behavior across the life span is largely unknown. This is why the role of previous experience in subsequent memory performances has been studied in a combined longitudinal (animals repeatedly tested) and cross-sectional (animals tested once at various ages) study, in male Sprague-Dawley r...

journal_title：Neurobiology of learning and memory

authors： Dellu F,Mayo W,Vallee M,Le Moal M,Simon H

更新日期：1997-03-01 00:00:00

abstract：:Growing evidence indicates that antagonists of the 5-hydroxytryptamine (serotonin) receptor(6) (5-HT(6)) improve memory and reverse amnesia although the mechanisms involved are poorly understood. Hence, in this paper RT-PCR was used to evaluate changes in mRNA expression of 5-HT(6) receptor in trained and untrained ra...

journal_title：Neurobiology of learning and memory

authors： Huerta-Rivas A,Pérez-García G,González-Espinosa C,Meneses A

更新日期：2010-01-01 00:00:00

abstract：:MsrB1 belongs to the methionine sulfoxide reductase family, it is also known as selenoprotein R for the sake of possessing a selenocysteine residue. It has been reported that MsrB1 could interact with actin, TRPM6, clusterin, and amyloid-beta in vitro. Thus, we presumed that MsrB1 may play an important role in central...

journal_title：Neurobiology of learning and memory

authors： Shi T,Yang Y,Zhang Z,Zhang L,Song J,Ping Y,Du X,Song G,Liu Q,Li N

更新日期：2019-12-01 00:00:00

abstract：:Persistence is an attribute of long-term memories (LTM) that has recently caught researcher's attention in search for mechanisms triggered by experience that assure memory perdurability. Up-to-date, scarce evidence of relationship between reconsolidation and persistence has been described. Here, we characterized hippo...

journal_title：Neurobiology of learning and memory

authors： Krawczyk MC,Navarro N,Blake MG,Romano A,Feld M,Boccia MM

更新日期：2016-09-01 00:00:00

abstract：:Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-кB), which are present before the neuronal activity induced by training. It was proposed t...

journal_title：Neurobiology of learning and memory

authors： Zalcman G,Federman N,de la Fuente V,Romano A

更新日期：2015-03-01 00:00:00

abstract：:Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form of discrepancies between actual and expected reward outcomes. Additionally, in learn...

journal_title：Neurobiology of learning and memory

authors： Hart AS,Clark JJ,Phillips PEM

更新日期：2015-01-01 00:00:00