Transgenic inhibition of neuronal calcineurin activity in the forebrain facilitates fear conditioning, but inhibits the extinction of contextual fear memories.

abstract：:A common conceptualization of the organization of memory systems in brain is that different types of memory are mediated by distinct neural systems. Strong support for this view comes from studies that show double (or triple) dissociations between spatial, response, and emotional memories following selective lesions o...

journal_title：Neurobiology of learning and memory

authors： Mizumori SJ,Yeshenko O,Gill KM,Davis DM

更新日期：2004-11-01 00:00:00

abstract：:Learning is ubiquitous in the animal kingdom but has been studied extensively in only a handful of species. Moreover, learning studied under laboratory conditions is typically unrelated to the animal's natural environment or life history. Here, we designed a task relevant to the natural behavior of male African cichli...

journal_title：Neurobiology of learning and memory

authors： Wood LS,Desjardins JK,Fernald RD

更新日期：2011-03-01 00:00:00

abstract：:Early life adverse events can lead to structural and functional impairments in the prefrontal cortex (PFC). Here, we investigated whether maternal deprivation (MD) alters PFC-dependent executive functions, neurons and astrocytes number and synaptic plasticity in adult male Long-Evans rats. The deprivation protocol con...

journal_title：Neurobiology of learning and memory

authors： Baudin A,Blot K,Verney C,Estevez L,Santamaria J,Gressens P,Giros B,Otani S,Daugé V,Naudon L

更新日期：2012-10-01 00:00:00

abstract：:Temporal lobe epilepsy patients have demonstrated a relative preservation in the integrity of implicit memory procedures. We examined performance in a verbal implicit and explicit memory task in left anterior temporal lobectomy patients (LATL) and healthy normal controls (NCs) while undergoing fMRI. We hypothesized th...

journal_title：Neurobiology of learning and memory

authors： Tracy JI,Osipowicz K,Godofsky S,Shah A,Khan W,Sharan A,Sperling MR

更新日期：2012-10-01 00:00:00

abstract：:The hippocampus is important for memory and learning, being a brain site where initial memories are formed and where sharp wave - ripples (SWR) are found, which are responsible for mapping recent memories to long-term storage during sleep-related memory replay. While this conceptual schema is well established, specifi...

journal_title：Neurobiology of learning and memory

authors： Malerba P,Bazhenov M

更新日期：2019-04-01 00:00:00

abstract：:The shell division of the nucleus accumbens receives noradrenergic input from neurons in the nucleus of the solitary tract (NTS) that transmit information regarding fluctuations in peripheral hormonal and autonomic activity. Accumbens shell neurons also receive converging inputs from limbic areas such as the hippocamp...

journal_title：Neurobiology of learning and memory

authors： Kerfoot EC,Chattillion EA,Williams CL

更新日期：2008-01-01 00:00:00

abstract：:Accumulating evidence indicates that homeostatic plasticity mechanisms dynamically adjust synaptic strength to promote stability that is crucial for memory storage. Our previous studies have shown that prior training in conditioned taste aversion (CTA) prevents the subsequent induction of long-term potentiation (LTP) ...

journal_title：Neurobiology of learning and memory

authors： Rivera-Olvera A,Nelson-Mora J,Gonsebatt ME,Escobar ML

更新日期：2018-10-01 00:00:00

abstract：:Intracerebral muscimol injection is widely used to inactivate discrete brain structures during behavioral tasks. However, little effort has been made to quantify the extent of muscimol diffusion. The authors report here electrophysiological and autoradiographic results obtained after muscimol injection (1 microg/micro...

journal_title：Neurobiology of learning and memory

authors： Edeline JM,Hars B,Hennevin E,Cotillon N

更新日期：2002-07-01 00:00:00

abstract：:The present study examined the effects of posttraining ethanol administration upon retention of an appetitive task using a variety of retention behaviors associated with the task. Male C57BL/6J mice were individually trained to find a cheese pellet placed in the corner of an open field. Five behavioral measures were u...

journal_title：Neurobiology of learning and memory

authors： Ladner CJ,Babbini M,Davies DL,Parker ES,Alkana RL

更新日期：2001-01-01 00:00:00

abstract：:Socially housed mice with cytotoxic lesions of the hippocampus do not exhibit social recognition memory 30 min following exposure to a juvenile mouse, however the social recognition memory of singly housed rats is unimpaired. The present study tests the hypothesis that social housing of rats could render social recogn...

journal_title：Neurobiology of learning and memory

authors： Squires AS,Peddle R,Milway SJ,Harley CW

更新日期：2006-01-01 00:00:00

abstract：:Chronic high-frequency repetitive transcranial magnetic stimulation (rTMS) is a noninvasive method to increase the excitability of neurons, and it induces long-term effects that can improve symptoms related to neurodegenerative diseases, including cognitive ability. The present study was undertaken to identify the mec...

journal_title：Neurobiology of learning and memory

authors： Wang HL,Xian XH,Wang YY,Geng Y,Han B,Wang MW,Li WB

更新日期：2015-02-01 00:00:00

abstract：:Male songbirds learn to produce song within a limited phase early in life; however they continue to learn to recognize songs in adulthood. Studies looking at Zenk activation after exposure to songs learned early in life for song production and songs learned in adulthood show opposite patterns of activation, suggesting...

journal_title：Neurobiology of learning and memory

authors： McKenzie TL,Hernandez AM,MacDougall-Shackleton SA

更新日期：2006-11-01 00:00:00

abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

journal_title：Neurobiology of learning and memory

authors： Stilling RM,Fischer A

更新日期：2011-07-01 00:00:00

abstract：:It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...

journal_title：Neurobiology of learning and memory

authors： Roesler R

更新日期：2017-07-01 00:00:00

abstract：:Relapse to drug use is often precipitated by exposure to drug associated cues that evoke craving. Cue-induced drug craving has been observed in both animals and humans to increase over the first few weeks of abstinence and remain high over extended periods, a phenomenon known as 'incubation of craving'. As adolescence...

journal_title：Neurobiology of learning and memory

authors： Madsen HB,Zbukvic IC,Luikinga SJ,Lawrence AJ,Kim JH

更新日期：2017-09-01 00:00:00

abstract：:Pre-verbal infants and non-human animals associate small numbers with the left space and large numbers with the right space. Birds and primates, trained to identify a given position in a sagittal series of identical positions, whenever required to respond on a left/right oriented series, referred the given position st...

journal_title：Neurobiology of learning and memory

authors： Rugani R,Vallortigara G,Regolin L

更新日期：2016-09-01 00:00:00

abstract：:It has recently become widely appreciated that value-based decision making is supported by multiple computational strategies. In particular, animal and human behavior in learning tasks appears to include habitual responses described by prominent model-free reinforcement learning (RL) theories, but also more deliberati...

journal_title：Neurobiology of learning and memory

authors： Doll BB,Shohamy D,Daw ND

更新日期：2015-01-01 00:00:00

abstract：:Although social, physical, and cognitive activities have each been suggested to reduce the risk of Alzheimer's disease (AD), epidemiologic studies cannot determine which activity or combination of activities is most important. To address this question, mutant APP transgenic AD mice were reared long-term in one of four...

journal_title：Neurobiology of learning and memory

authors： Cracchiolo JR,Mori T,Nazian SJ,Tan J,Potter H,Arendash GW

更新日期：2007-10-01 00:00:00

abstract：:Previously, we demonstrated that mice in which the gene for the L-type voltage-gated calcium channel Ca(V)1.3 is deleted (Ca(V)1.3 knockout mice) exhibit an impaired ability to consolidate contextually-conditioned fear. Given that this form of Pavlovian fear conditioning is critically dependent on the basolateral comp...

journal_title：Neurobiology of learning and memory

authors： McKinney BC,Sze W,Lee B,Murphy GG

更新日期：2009-11-01 00:00:00

abstract：:The present work shows that the dorsomedial telencephalic pallium of teleost fish, proposed as homologous to the amygdala of mammals, is involved in taste aversion learning (TAL). To analyze the behavioral properties of TAL in goldfish, in Experiment 1, we used a delayed procedure similar to that employed with mammals...

journal_title：Neurobiology of learning and memory

authors： Martín I,Gómez A,Salas C,Puerto A,Rodríguez F

更新日期：2011-09-01 00:00:00

abstract：:The aim of the present study was to investigate the effects of paradoxical sleep deprivation (PSD) for 96 h on the learning/memory processes in rats submitted to the plus-maze discriminative avoidance task (PM-DAT), which simultaneously evaluates learning, memory, anxiety and motor function. Four experiments were perf...

journal_title：Neurobiology of learning and memory

authors： Alvarenga TA,Patti CL,Andersen ML,Silva RH,Calzavara MB,Lopez GB,Frussa-Filho R,Tufik S

更新日期：2008-11-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:Post-traumatic stress disorder (PTSD) is a condition that develops after an individual has experienced a major trauma. Currently, selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are the first-line choice in PTSD drug treatment but their moderate response rates and side effects indicate an urgent need f...

journal_title：Neurobiology of learning and memory

authors： Shafia S,Vafaei AA,Samaei SA,Bandegi AR,Rafiei A,Valadan R,Hosseini-Khah Z,Mohammadkhani R,Rashidy-Pour A

更新日期：2017-03-01 00:00:00

abstract：:It is well established that D-cycloserine (DCS), a partial agonist of the NMDA receptor glycine site, enhances learning and memory processes. Although the effects of DCS have been especially elucidated in the extinction and reconsolidation of aversive behavioral paradigms or drug-related behaviors, they have not been ...

journal_title：Neurobiology of learning and memory

authors： Portero-Tresserra M,Martí-Nicolovius M,Guillazo-Blanch G,Boadas-Vaello P,Vale-Martínez A

更新日期：2013-02-01 00:00:00

abstract：:Anxiety disorders and obesity are both common in youth and young adults. Despite increasing evidence that over-consumption of palatable high-fat/high-sugar "junk" foods leads to adverse neurocognitive outcomes, little is known about the effects of palatable diets on emotional memories and fear regulation. In the prese...

journal_title：Neurobiology of learning and memory

authors： Baker KD,Reichelt AC

更新日期：2016-12-01 00:00:00

abstract：:Sleep is involved in both the consolidation of discrete episodes, as well as the generalisation of acquired memories into schemata. Here, we have isolated early versus late periods of sleep in order to replicate previous behavioural findings and to demonstrate: i) that distinct sleep and sleep electroencephalography (...

journal_title：Neurobiology of learning and memory

authors： Chatburn A,Lushington K,Kohler MJ

更新日期：2021-01-15 00:00:00

abstract：:The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. H...

journal_title：Neurobiology of learning and memory

authors： Aguilar MA,Miñarro J,Simón VM

更新日期：1998-03-01 00:00:00

abstract：:It has been proposed that normal waking levels of acetylcholine (ACH) are important for initial memory acquisition, and that decreased ACH is critical for memory consolidation. Sleep is thought to benefit memory consolidation in part due to the predominance of low ACH levels observed during non-rapid eye movement slee...

journal_title：Neurobiology of learning and memory

authors： Tucker MA,Taylor K,Merchant R,George S,Stoddard C,Kopera K

更新日期：2018-11-01 00:00:00

abstract：:The long-lasting effects of gestational cannabinoids exposure on the adult brain of the offspring are still controversial. It has already been shown that pre- or perinatal cannabinoids exposure induces learning and memory disruption in rat adult offspring, associated with permanent alterations of cortical glutamatergi...

journal_title：Neurobiology of learning and memory

authors： Beggiato S,Borelli AC,Tomasini MC,Morgano L,Antonelli T,Tanganelli S,Cuomo V,Ferraro L

更新日期：2017-03-01 00:00:00

abstract：:Synaptic plasticity is subject to activity-dependent long-term modification (metaplasticity). We have recently described a novel form of heterosynaptic metaplasticity in hippocampal CA1, whereby 'priming' activity at one set of synapses confers a metaplastic state that inhibits subsequent LTP both within and between d...

journal_title：Neurobiology of learning and memory

authors： Jones OD,Hulme SR,Abraham WC

更新日期：2013-10-01 00:00:00