Abstract:
:The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lower concentrations of (+)-SKF 10047 did not disrupt memory formation. The amnesia produced by the efficacious dose of (+)-SKF 10047 was reversed by the specific antagonist, BD 1047. It is suggested that the sigma-receptor may exert its effect on passive-avoidance memory consolidation during the later stages of long-term memory formation by modulation of memory-related neurotransmission.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Freeman FM,Young IGdoi
10.1006/nlme.2000.3985keywords:
subject
Has Abstractpub_date
2001-05-01 00:00:00pages
346-52issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(00)93985-6journal_volume
75pub_type
杂志文章abstract::The hypotheses that the medial septal area (MSA) is critical for working memory and that MSA neural activity is positively regulated by cholinergic inputs leads to two testable predictions: (1) working memory can be bidirectionally modulated by muscarinic manipulations of the MSA and (2) muscarinic activation of the M...
journal_title:Neurobiology of learning and memory
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1006/nlme.1995.1031
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journal_title:Neurobiology of learning and memory
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
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journal_title:Neurobiology of learning and memory
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