Involvement of the sigma receptor in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.

Abstract:

:The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lower concentrations of (+)-SKF 10047 did not disrupt memory formation. The amnesia produced by the efficacious dose of (+)-SKF 10047 was reversed by the specific antagonist, BD 1047. It is suggested that the sigma-receptor may exert its effect on passive-avoidance memory consolidation during the later stages of long-term memory formation by modulation of memory-related neurotransmission.

journal_name

Neurobiol Learn Mem

authors

Freeman FM,Young IG

doi

10.1006/nlme.2000.3985

keywords:

subject

Has Abstract

pub_date

2001-05-01 00:00:00

pages

346-52

issue

3

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(00)93985-6

journal_volume

75

pub_type

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