当前位置： SCI文献检索 > NEUROBIOLOGY OF LEARNING AND MEMORY期刊下所有文献 > Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines.

Estradiol and ERβ agonists enhance recognition memory, and DPN, an ERβ agonist, alters brain monoamines.

Abstract：

:Effects of estradiol benzoate (EB), ERα-selective agonist, propyl pyrazole triol (PPT) and ERβ-selective agonists, diarylpropionitrile (DPN) and Compound 19 (C-19) on memory were investigated in OVX rats using object recognition (OR) and placement (OP) memory tasks. Treatments were acute (behavior 4h later) or sub chronic (daily injections for 2 days with behavior 48 h later). Objects were explored in sample trials (T1), and discrimination between sample (old) and new object/location in recognition trials (T2) was examined after 2-4h inter-trial delays. Subjects treated sub chronically with EB, DPN, and C-19, but not PPT, discriminated between old and new objects and objects in old and new locations, suggesting that, at these doses and duration of treatments, estrogenic interactions with ERβ contribute to enhancements in recognition memory. Acute injections of DPN, but not PPT, immediately after T1, also enhanced discrimination for both tasks (C19 was not investigated). Effects of EB, DPN and PPT on anxiety and locomotion, measured on elevated plus maze and open field, did not appear to account for the mnemonic enhancements. Monoamines and metabolites were measured following DPN treatment in subjects that did not receive behavioral testing. DPN was associated with alterations in monoamines in several brain areas: indexed by the metabolite, 3-methoxy-4-hydroxyphenylglycol (MHPG), or the MHPG/norepinephrine (NE) ratio, NE activity was increased by 60-130% in the prefrontal cortex (PFC) and ventral hippocampus, and NE activity was decreased by 40-80% in the v. diagonal bands and CA1. Levels of the dopamine (DA) metabolite, homovanillic acid (HVA), increased 100% in the PFC and decreased by 50% in the dentate gyrus following DPN treatment. The metabolite of serotonin, 5-hydroxyindole acetic acid (5-HIAA), was increased in the PFC and CA3, by approximately 20%. No monoaminergic changes were noted in striatum or medial septum. Results suggest that ERβ mediates sub chronic and acute effects of estrogens on recognition memory and that memory enhancements by DPN may occur, in part, through alterations in monoaminergic containing systems primarily in PFC and hippocampus.

journal_name

Neurobiol Learn Mem

journal_title

Neurobiology of learning and memory

authors

Jacome LF,Gautreaux C,Inagaki T,Mohan G,Alves S,Lubbers LS,Luine V

doi

10.1016/j.nlm.2010.08.016

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

488-98

issue

4

eissn

1074-7427

issn

1095-9564

pii

S1074-7427(10)00142-5

journal_volume

94

pub_type

杂志文章

相关文献

NEUROBIOLOGY OF LEARNING AND MEMORY文献大全
  • Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation.

    abstract：:Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.04.009

    authors： Collins BE,Sweatt JD,Greer CB

    更新日期：2019-05-01 00:00:00

  • Mechanisms of Context Conditioning in the Developing Rat.

    abstract：:The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2021.107388

    authors： Stanton ME,Murawski NJ,Jablonski SA,Robinson-Drummer PA,Heroux NA

    更新日期：2021-01-19 00:00:00

  • Sex differences in vulnerability to developmental spatial learning deficits induced by limited binge alcohol exposure in neonatal rats.

    abstract：:The two main objectives of this study were (1) to replicate previous findings that 6 days of binge-like exposure to alcohol during the neonatal brain growth spurt induces significant place learning deficits in juvenile rats and (2) to determine whether more limited (3-day) binge-like exposure during the neonatal perio...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1995.0009

    authors： Goodlett CR,Peterson SD

    更新日期：1995-11-01 00:00:00

  • "Despair" induced by extinction trials in the water maze: relationship with measures of anxiety in aged and adult rats.

    abstract：:We have previously reported that extinction of escape behavior in the water maze due to the removal of the platform coincided with the development of behavioral "despair" in aged and adult rats, as assessed by immobility. The present study examines further predictions derived from the hypothesis that the withholding o...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.09.006

    authors： Schulz D,Huston JP,Buddenberg T,Topic B

    更新日期：2007-03-01 00:00:00

  • Modulation of adenosine signaling prevents scopolamine-induced cognitive impairment in zebrafish.

    abstract：:Adenosine, a purine ribonucleoside, exhibits neuromodulatory and neuroprotective effects in the brain and is involved in memory formation and cognitive function. Adenosine signaling is mediated by adenosine receptors (A1, A2A, A2B, and A3); in turn, nucleotide and nucleoside-metabolizing enzymes and adenosine transpor...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.11.016

    authors： Bortolotto JW,Melo GM,Cognato Gde P,Vianna MR,Bonan CD

    更新日期：2015-02-01 00:00:00

  • Background illumination effects upon in vitro conditioning in Hermissenda.

    abstract：:In the marine snail Hermissenda, associative learning can be accomplished by paired presentations of light and vestibular stimulation. It is generally assumed that associative learning depends upon the intensity or salience of the conditioned or unconditioned stimulus (CS and US, respectively). Accordingly, during Her...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1999.3938

    authors： Tomsic D,Alkon DL

    更新日期：2000-07-01 00:00:00

  • Memory enhancement by a semantically unrelated emotional arousal source induced after learning.

    abstract：:It has been well established that moderate physiological or emotional arousal modulates memory. However, there is some controversy about whether the source of arousal must be semantically related to the information to be remembered. To test this idea, 35 healthy young adult participants learned a list of common nouns ...

    journal_title：Neurobiology of learning and memory

    pub_type： 临床试验,杂志文章

    doi：10.1016/j.nlm.2005.04.001

    authors： Nielson KA,Yee D,Erickson KI

    更新日期：2005-07-01 00:00:00

  • Neurophysiological substrates of context conditioning in Hermissenda suggest a temporally invariant form of activity-dependent neuronal facilitation.

    abstract：:The neurophysiological basis for context conditioning is conceptually problematic because neurophysiological descriptions of activity-dependent (associative) forms of neuronal plasticity uniformly assume that a specific temporal relationship between signals is necessary for memory induction. In the present experiments...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1998.3890

    authors： Talk AC,Muzzio IA,Matzel LD

    更新日期：1999-09-01 00:00:00

  • Posterior insular cortex is necessary for conditioned inhibition of fear.

    abstract：:Veridical detection of safety versus danger is critical to survival. Learned signals for safety inhibit fear, and so when presented, reduce fear responses produced by danger signals. This phenomenon is termed conditioned inhibition of fear. Here, we report that CS+/CS- fear discrimination conditioning over 5 days in r...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.08.004

    authors： Foilb AR,Flyer-Adams JG,Maier SF,Christianson JP

    更新日期：2016-10-01 00:00:00

  • Coincident induction of long-term facilitation at sensory-motor synapses in Aplysia: presynaptic and postsynaptic factors.

    abstract：:Induction of long-term synaptic changes at one synapse can facilitate the induction of long-term plasticity at another synapse. Here we show that if Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, which at either site alone are insuff...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2002.4092

    authors： Sherff CM,Carew TJ

    更新日期：2002-11-01 00:00:00

  • Pathobiology of Christianson syndrome: Linking disrupted endosomal-lysosomal function with intellectual disability and sensory impairments.

    abstract：:Christianson syndrome (CS) is a recently described rare neurogenetic disorder presenting early in life with a broad range of neurological symptoms, including severe intellectual disability with nonverbal status, hyperactivity, epilepsy, and progressive ataxia due to cerebellar atrophy. CS is due to loss-of-function mu...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.05.004

    authors： Kerner-Rossi M,Gulinello M,Walkley S,Dobrenis K

    更新日期：2019-11-01 00:00:00

  • Visuospatial word search task only effective at disrupting declarative memory when prediction error is present during retrieval.

    abstract：:Prediction error is recognized as a necessary boundary condition for memory reactivation and reconsolidation. Furthermore, behavioral manipulations (e.g., visuospatial interference tasks, like Tetris) have been shown to be effective at disrupting reactivated memory. In the present study, participants created a memory ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.11.003

    authors： Gotthard GH,Gura H

    更新日期：2018-12-01 00:00:00

  • Autism Spectrum Disorders: Translating human deficits into mouse behavior.

    abstract：:Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders, with rising incidence but little effective therapeutic intervention available. Currently two main clinical features are described to diagnose ASDs: impaired social interaction and communication, and repetitive behaviors. Much work has...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2015.07.013

    authors： Pasciuto E,Borrie SC,Kanellopoulos AK,Santos AR,Cappuyns E,D'Andrea L,Pacini L,Bagni C

    更新日期：2015-10-01 00:00:00

  • Experience with songs in adulthood reduces song-induced gene expression in songbird auditory forebrain.

    abstract：:Male songbirds learn to produce song within a limited phase early in life; however they continue to learn to recognize songs in adulthood. Studies looking at Zenk activation after exposure to songs learned early in life for song production and songs learned in adulthood show opposite patterns of activation, suggesting...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2006.05.002

    authors： McKenzie TL,Hernandez AM,MacDougall-Shackleton SA

    更新日期：2006-11-01 00:00:00

  • Cytotoxic lesions of the hippocampus do not impair social recognition memory in socially housed rats.

    abstract：:Socially housed mice with cytotoxic lesions of the hippocampus do not exhibit social recognition memory 30 min following exposure to a juvenile mouse, however the social recognition memory of singly housed rats is unimpaired. The present study tests the hypothesis that social housing of rats could render social recogn...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2005.08.012

    authors： Squires AS,Peddle R,Milway SJ,Harley CW

    更新日期：2006-01-01 00:00:00

  • Olfactory discrimination learning in mice lacking the fragile X mental retardation protein.

    abstract：:An automated training system was used to compare the behavior of knockout (KO) mice lacking the fragile X mental retardation protein with that of wild-type (WT) mice (C57Bl/6 strain) in the acquisition and retention of olfactory discriminations. KO and WT mice did not differ in the acquisition of a four-stage nose pok...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2008.01.002

    authors： Larson J,Kim D,Patel RC,Floreani C

    更新日期：2008-07-01 00:00:00

  • ADRB2 gene polymorphism modulates the retention of fear extinction memory.

    abstract：:Individual differences in regulation of fear and extinction memory play significant roles in the aetiology development of post-traumatic stress disorder (PTSD). Previous animal based studies showed that the activity of β-adrenergic receptors (β-ARs) are involved in memory modulation. However in humans it is not clear ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2018.11.004

    authors： Shi L,Chen SJ,Deng JH,Que JY,Lin X,Sun Y,Bao YP,Shi J,Lu L

    更新日期：2018-12-01 00:00:00

  • Inhibition of guanylate cyclase and protein kinase G impairs retention for the passive avoidance task in the day-old chick.

    abstract：:Nitric oxide (NO) is a highly labile chemical messenger which has previously been implicated in memory processes in a variety of learning paradigms and species. However, there is only limited evidence to suggest which enzymes are acted upon by NO during the formation of memory. The present study investigates the role ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.2001.4021

    authors： Edwards TM,Rickard NS,Ng KT

    更新日期：2002-05-01 00:00:00

  • Slow-wave disruption enhances the accessibility of positive memory traces.

    abstract：:The purpose of this study was to explore the effects of slow-wave disruption on positive and negative word recognition in a sample of healthy control participants and those with major depressive disorder. Prior to sleep, participants learned a set of emotional and neutral words during an encoding task by responding wh...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2015.09.006

    authors： Goldschmied JR,Cheng P,Kim HS,Casement M,Armitage R,Deldin PJ

    更新日期：2015-11-01 00:00:00

  • Frontal cortex stroke-induced impairment in spatial working memory on the trial-unique nonmatching-to-location task in mice.

    abstract：:Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2020.107355

    authors： Houlton J,Barwick D,Clarkson AN

    更新日期：2021-01-01 00:00:00

  • Age-related forgetting in locomotor adaptation.

    abstract：:The healthy aging process affects the ability to learn and remember new facts and tasks. Prior work has shown that motor learning can be adversely affected by non-motor deficits, such as time. Here we investigated how age, and a dual task influence the learning and forgetting of a new walking pattern. We studied healt...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2015.11.003

    authors： Malone LA,Bastian AJ

    更新日期：2016-02-01 00:00:00

  • The role of histone acetylation in age-associated memory impairment and Alzheimer's disease.

    abstract：:Learning and memory are cognitive processes that are tightly regulated. A proper genome-environment interaction is a pre-requisite for cognitive function. Epigenetic processes are central regulators of genome-environment interactions. In line with this, it has been shown that the epigenetic machinery is essential for ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2011.04.002

    authors： Stilling RM,Fischer A

    更新日期：2011-07-01 00:00:00

  • Na+,K(+)-ATPase activity is reduced in hippocampus of rats submitted to an experimental model of depression: effect of chronic lithium treatment and possible involvement in learning deficits.

    abstract：:This study was undertaken to verify the effects of chronic stress and lithium treatments on the hippocampal Na+,K(+)-ATPase activity of rats, as well as to investigate the effects of stress interruption and post-stress lithium treatment on this enzyme activity and on spatial memory. Two experiments were carried out; i...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2005.05.002

    authors： de Vasconcellos AP,Zugno AI,Dos Santos AH,Nietto FB,Crema LM,Gonçalves M,Franzon R,de Souza Wyse AT,da Rocha ER,Dalmaz C

    更新日期：2005-09-01 00:00:00

  • Cerebellar learning modulates surface expression of a voltage-gated ion channel in cerebellar cortex.

    abstract：:Numerous experiments using ex vivo electrophysiology suggest that mammalian learning and memory involves regulation of voltage-gated ion channels in terms of changes in function. Yet, little is known about learning-related regulation of voltage-gated ion channels in terms of changes in expression. In two experiments, ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.05.009

    authors： Fuchs JR,Darlington SW,Green JT,Morielli AD

    更新日期：2017-07-01 00:00:00

  • Facilitation of cognitive performance in aged rats by past experience depends on the type of information processing involved: a combined cross-sectional and longitudinal study.

    abstract：:The impact of past history on behavior across the life span is largely unknown. This is why the role of previous experience in subsequent memory performances has been studied in a combined longitudinal (animals repeatedly tested) and cross-sectional (animals tested once at various ages) study, in male Sprague-Dawley r...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1006/nlme.1996.3750

    authors： Dellu F,Mayo W,Vallee M,Le Moal M,Simon H

    更新日期：1997-03-01 00:00:00

  • d-Cycloserine and estradiol enhance fear extinction in nulliparous but not primiparous female rats.

    abstract：:Female reproductive experience has been shown to alter the hormonal, neurobiological and behavioural features of fear extinction, which is the laboratory basis of exposure therapy. This raises uncertainties as to whether pharmacological agents that enhance fear extinction in reproductively inexperienced females are eq...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2019.107088

    authors： Tang S,Graham BM

    更新日期：2019-12-01 00:00:00

  • Memory deficits with intact cognitive control in the methylazoxymethanol acetate (MAM) exposure model of neurodevelopmental insult.

    abstract：:Cognitive impairments are amongst the most debilitating deficits of schizophrenia and the best predictor of functional outcome. Schizophrenia is hypothesized to have a neurodevelopmental origin, making animal models of neurodevelopmental insult important for testing predictions that early insults will impair cognitive...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2016.07.034

    authors： O'Reilly KC,Perica MI,Fenton AA

    更新日期：2016-10-01 00:00:00

  • Dynamic shaping of dopamine signals during probabilistic Pavlovian conditioning.

    abstract：:Cue- and reward-evoked phasic dopamine activity during Pavlovian and operant conditioning paradigms is well correlated with reward-prediction errors from formal reinforcement learning models, which feature teaching signals in the form of discrepancies between actual and expected reward outcomes. Additionally, in learn...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2014.07.010

    authors： Hart AS,Clark JJ,Phillips PEM

    更新日期：2015-01-01 00:00:00

  • The perisylvian language network and language analytical abilities.

    abstract：:Aiming at exploring the brain's structural organisation underlying successful second language learning, we investigate the anatomy of the perisylvian language network in a group of healthy adults, consisting of participants with high and average language analytical abilities. Utilising deterministic tractography, six ...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章

    doi：10.1016/j.nlm.2017.07.003

    authors： Kepinska O,Lakke EAJF,Dutton EM,Caspers J,Schiller NO

    更新日期：2017-10-01 00:00:00

  • Parallel processing across neural systems: implications for a multiple memory system hypothesis.

    abstract：:A common conceptualization of the organization of memory systems in brain is that different types of memory are mediated by distinct neural systems. Strong support for this view comes from studies that show double (or triple) dissociations between spatial, response, and emotional memories following selective lesions o...

    journal_title：Neurobiology of learning and memory

    pub_type： 杂志文章,评审

    doi：10.1016/j.nlm.2004.07.007

    authors： Mizumori SJ,Yeshenko O,Gill KM,Davis DM

    更新日期：2004-11-01 00:00:00