Abstract:
:This study was undertaken to verify the effects of chronic stress and lithium treatments on the hippocampal Na+,K(+)-ATPase activity of rats, as well as to investigate the effects of stress interruption and post-stress lithium treatment on this enzyme activity and on spatial memory. Two experiments were carried out; in the first experiment, adult male Wistar rats were divided into two groups: control and submitted to a chronic variate stress paradigm, and subdivided into treated or not with LiCl. After 40 days of treatment, rats were killed, and Na+,K(+)-ATPase activity was determined. In the second experiment, rats were stressed during 40 days, and their performance was evaluated in the Water Maze task. The stressed group was then subdivided into four groups, with continued or interrupted stress treatment and treated or not with lithium for 30 additional days. After a second evaluation of performance in the Water Maze, rats were killed and Na+,K(+)-ATPase activity was also measured. Results showed an impairment in Na+,K(+)-ATPase activity and in Water Maze performance of chronically stressed rats, which were prevented by lithium treatment and reversed by lithium treatment and by stress interruption. These results suggest that the modulation of Na+,K(+)-ATPase activity may be one of the mechanisms of action of lithium in the treatment of mood disorders.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
de Vasconcellos AP,Zugno AI,Dos Santos AH,Nietto FB,Crema LM,Gonçalves M,Franzon R,de Souza Wyse AT,da Rocha ER,Dalmaz Cdoi
10.1016/j.nlm.2005.05.002keywords:
subject
Has Abstractpub_date
2005-09-01 00:00:00pages
102-10issue
2eissn
1074-7427issn
1095-9564pii
S1074-7427(05)00039-0journal_volume
84pub_type
杂志文章abstract::In insects, cholinergic neurons are thought to transmit olfactory conditioned stimulus (CS) to the sites for associating the CS with unconditioned stimulus (US), but the types of acetylcholine (ACh) receptor used by neurons participating in the association have not been determined. In cockroaches, a type of nicotinic ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2010.10.004
更新日期:2011-01-01 00:00:00
abstract::Down syndrome (DS) has an incidence of about 1/700 births, and is therefore the most common cause of cognitive and behavioral impairments in children. Recent studies on mouse models of DS indicate that a number of pharmacotherapies could be beneficial for restoring cognitive abilities in individuals with DS. Attention...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2014.10.002
更新日期:2014-12-01 00:00:00
abstract::Inhibitors of protein and mRNA syntheses inhibit long-term memory (LTM), but we lack information about the time windows during which those inhibitors are effective. Anisomycin (a protein synthesis translation inhibitor) was given to Hermissenda crassicornis which had received sufficient Pavlovian conditioning to produ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/s1074-7427(02)00020-5
更新日期:2003-03-01 00:00:00
abstract::Two experiments investigated the potential facilitative effects of prior instructed awareness and predetermined learning criteria on humans' ability to make transitive inference (TI) judgments. Participants were first exposed to a learning phase and required to learn five premise pairs (A+B-, B+C-, C+D-, D+E-, E+F-). ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2014.01.004
更新日期:2014-03-01 00:00:00
abstract::Previous work done by our laboratory has demonstrated a reduction of the post-burst afterhyperpolarization (AHP) and accommodation following trace eyeblink conditioning in rabbit CA1 pyramidal neurons. Our laboratory has also demonstrated a reduction in the AHP in rat CA1 pyramidal neurons following spatial learning. ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2007.07.002
更新日期:2008-02-01 00:00:00
abstract::Different exercise paradigms show differential effects on various forms of memory. We hypothesize that the differential effects of exercises on memory performance are caused by different neuroplasticity changes in relevant brain regions in response to different exercise trainings. We examined the effects of treadmill ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2011.10.006
更新日期:2012-01-01 00:00:00
abstract::Regional differences in large-scale connectivity have been proposed to underlie functional specialization along the anterior-posterior axis of the medial temporal lobe (MTL), including the hippocampus (HC) and the parahippocampal gyrus (PHG). However, it is unknown whether functional connectivity (FC) can be used reli...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.01.005
更新日期:2016-10-01 00:00:00
abstract::Testosterone (T) may enhance cognitive performance. However, its mechanisms are not well understood. First, we hypothesized that if T's effects are mediated in part through actions of its 5alpha-reduced metabolites, dihydrotestosterone (DHT) and/or 3alpha-androstanediol (3alpha-diol) in the hippocampus, then T, DHT, a...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2006.07.001
更新日期:2007-01-01 00:00:00
abstract::Addiction is increasingly discussed asa disorder of associative learning processes, with both operant and classical conditioning contributing to the development of maladaptive habits. Stress has long been known to promote drug taking and relapse and has further been shown to shift behavior from goal-directed actions t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2017.09.003
更新日期:2017-11-01 00:00:00
abstract::Obesity is a worldwide epidemic that is increasing at an alarming rate. One of its causes is the increased availability and consumption of diets rich in fat. In the present study, we investigated the effects of short-term consumption of a high fat diet (HFD) on dietary preferences in Swiss CD1 mice and its relation in...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2013.10.018
更新日期:2014-01-01 00:00:00
abstract::It is currently well established that the synthesis of new proteins (mRNA translation) is required for long-lasting synaptic plasticity and memory formation. Translation in the brain is regulated primarily at the initiation stage by general as well as by gene-specific mechanisms. Stored memories can become sensitive t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2017.04.015
更新日期:2017-07-01 00:00:00
abstract::Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counterac...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2007.10.010
更新日期:2008-05-01 00:00:00
abstract::The article reviews our studies of contextual fear conditioning (CFC) in rats during a period of development---Postnatal Day (PND) 17-33---that represents the late-infant, juvenile, and early-adolescent stages. These studies seek to acquire 'systems level' knowledge of brain and memory development and apply it to a ro...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2021.107388
更新日期:2021-01-19 00:00:00
abstract::Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is histone 3 lysine 4 trimethylation (H3K4me3), and this ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2019.04.009
更新日期:2019-05-01 00:00:00
abstract::Adult Aplysia exhibit both short-term and long-term memory for sensitization in the gill and siphon withdrawal reflex. Previous developmental studies showed that short-term memory for sensitization emerges late in juvenile development (stage 12; Rankin and Carew, 1988; Wright et al., 1991). In the present study, we ex...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1996.0031
更新日期:1996-05-01 00:00:00
abstract::The effect of calcium channel antagonists (CCA's) on working and reference memory in mice was studied using spontaneous alternation (SA) behavior in a T maze. Mice were given either one or four forced trials to either the right or the left arm on the training session (T1) followed by a free choice test (T2) at varying...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.2000.3981
更新日期:2001-07-01 00:00:00
abstract::Stroke-induced cognitive impairments are of significant concern, however mechanisms that underpin these impairments remain poorly understood and researched. To further characterise cognitive impairments in our frontal cortex stroke model, and to align our assessments with what is used clinically, we tested young C57BL...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2020.107355
更新日期:2021-01-01 00:00:00
abstract::Recently developed neuroimaging and electrophysiological techniques are allowing us to answer fundamental questions about how behavioral states regulate our perception of the external environment. Studies using these techniques have yielded surprising insights into how sensory processing is affected at the earliest st...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2013.06.007
更新日期:2013-11-01 00:00:00
abstract::In a previous study, adult male Sprague-Dawley rats with unilateral, electrolytic entorhinal cortex lesions showed significant deficits in acquisition of a water maze task that measured working memory. The 10 days of testing used two trials per day with an intertrial interval of 1 h, and the rats with entorhinal damag...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1998.3832
更新日期:1999-01-01 00:00:00
abstract::Long-term memory formation requires gene expression after acquisition of new information. The first step in the regulation of gene expression is the participation of transcription factors (TFs) such as nuclear factor kappa B (NF-кB), which are present before the neuronal activity induced by training. It was proposed t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2014.12.013
更新日期:2015-03-01 00:00:00
abstract::Abstinent alcohol-dependent individuals experience an enduring sensitivity to cue-induced craving and relapse to drinking. There is considerable evidence indicating that structures within the midbrain and extended amygdala are involved in this process. Individually, the ventral tegmental area (VTA) and the bed nucleus...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.11.013
更新日期:2017-01-01 00:00:00
abstract::Females experience depression, posttraumatic stress disorder (PTSD), and anxiety disorders at approximately twice the rate of males, but the mechanisms underlying this difference remain undefined. The effect of sex hormones on neural substrates presents a possible mechanism. We investigated the effect of ovariectomy a...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2014.12.009
更新日期:2015-02-01 00:00:00
abstract::Episodic memory formation is considered a genuinely hippocampal function. Its study in rodents has relied on two different task paradigms, i.e. the so called "what-where-when" (WW-When) task and "what-where-which" (WW-Which) task. The WW-When task aims to assess the memory for an episode as an event bound into its con...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2018.05.013
更新日期:2019-04-01 00:00:00
abstract::Autism Spectrum Disorders are a heterogeneous group of neurodevelopmental disorders, with rising incidence but little effective therapeutic intervention available. Currently two main clinical features are described to diagnose ASDs: impaired social interaction and communication, and repetitive behaviors. Much work has...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2015.07.013
更新日期:2015-10-01 00:00:00
abstract::The current review provides a historical perspective on the evolution of hypothesized mechanisms for senescent neurophysiology, focused on the CA1 region of the hippocampus, and the relationship of senescent neurophysiology to impaired hippocampal-dependent memory. Senescent neurophysiology involves processes linked t...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2019.107064
更新日期:2019-10-01 00:00:00
abstract::Nitric oxide (NO) is a highly labile chemical messenger which has previously been implicated in memory processes in a variety of learning paradigms and species. However, there is only limited evidence to suggest which enzymes are acted upon by NO during the formation of memory. The present study investigates the role ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.2001.4021
更新日期:2002-05-01 00:00:00
abstract::The effects of morphine (6.3, 12.6, and 25.2 mg/kg) on active avoidance behavior of BALB/C mice are explored in three acquisition sessions and in two subsequent performance sessions. Morphine-treated animals showed an increase in avoidance acquisition with respect to control group without differences in performance. H...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1006/nlme.1997.3804
更新日期:1998-03-01 00:00:00
abstract::Variance in spatial abilities are thought to be determined by in utero levels of testosterone and oestrogen, measurable in adults by the length ratio of the 2nd and 4th digit (2D:4D). We confirmed the relationship between 2D:4D and spatial performance using rats in two different tasks (paired-associate task and waterm...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2018.04.012
更新日期:2018-05-01 00:00:00
abstract::Rett syndrome is an autism spectrum disorder and a leading cause of severe mental retardation in girls. The nature of the cognitive abnormalities in Rett, as described in humans and other animal models, and its potential reversibility and treatment are the subject of this review. Rett syndrome is associated with sever...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
doi:10.1016/j.nlm.2011.05.006
更新日期:2011-11-01 00:00:00
abstract::Epidemiological studies demonstrated association between head injury (HI) and the subsequent development of Alzheimer's disease (AD). Certain hallmarks of AD, e.g. amyloid-β (Aβ) containing deposits, may be found in patients following traumatic BI (TBI). Recent studies uncover the cellular prion protein, PrP(C), as a ...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2013.10.019
更新日期:2014-01-01 00:00:00