Abstract:
:We evaluated various forms of hippocampus-dependent learning and memory, and hippocampal synaptic plasticity in THY-Tau22 transgenic mice, a murine tauopathy model that expresses double-mutated 4-repeat human tau, and shows neuropathological tau hyperphosphorylation and aggregation throughout the brain. Focussing on hippocampus, immunohistochemical studies in aged THY-Tau22 mice revealed prominent hyper- and abnormal phosphorylation of tau in CA1 region, and an increase in glial fibrillary acidic protein (GFAP) in hippocampus, but without signs of neuronal loss. These mice displayed spatial, social, and contextual learning and memory defects that could not be reduced to subtle neuromotor disability. The behavioral defects coincided with changes in hippocampal synaptic functioning and plasticity as measured in paired-pulse and novel long-term depression protocols. These results indicate that hippocampal tauopathy without neuronal cell loss can impair neural and behavioral plasticity, and further show that transgenic mice, such as the THY-Tau22 strain, might be useful for preclinical research on tauopathy pathogenesis and possible treatment.
journal_name
Neurobiol Learn Memjournal_title
Neurobiology of learning and memoryauthors
Van der Jeugd A,Ahmed T,Burnouf S,Belarbi K,Hamdame M,Grosjean ME,Humez S,Balschun D,Blum D,Buée L,D'Hooge Rdoi
10.1016/j.nlm.2010.12.005subject
Has Abstractpub_date
2011-03-01 00:00:00pages
296-304issue
3eissn
1074-7427issn
1095-9564pii
S1074-7427(10)00209-1journal_volume
95pub_type
杂志文章abstract::Pre-verbal infants and non-human animals associate small numbers with the left space and large numbers with the right space. Birds and primates, trained to identify a given position in a sagittal series of identical positions, whenever required to respond on a left/right oriented series, referred the given position st...
journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2009.06.012
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
doi:10.1016/j.nlm.2016.07.034
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章,评审
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
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journal_title:Neurobiology of learning and memory
pub_type: 杂志文章
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