The consolidation of inhibitory avoidance memory in mice depends on the intensity of the aversive stimulus: The involvement of the amygdala, dorsal hippocampus and medial prefrontal cortex.

abstract：:Neuronal plasticity and neurogenesis occur in the adult hippocampus and in other brain structures such as the olfactory bulb and often involve the neural cell adhesion molecule NCAM. During an olfactory associative discrimination learning task, NCAM polysialylation triggers neuronal plasticity in the adult hippocampus...

journal_title：Neurobiology of learning and memory

authors： Mione J,Manrique C,Duhoo Y,Roman FS,Guiraudie-Capraz G

更新日期：2016-04-01 00:00:00

abstract：:Intrauterine adverse conditions may be responsible for long-lasting damages which impact health even during adult phase. Hypoxic-ischemic (HI) events are a relevant cause of newborn mortality and the principal factor leading to permanent brain lesions. Using a model in which the ovarian and uterine flux of a pregnant ...

journal_title：Neurobiology of learning and memory

authors： Cunha-Rodrigues MC,Balduci CTDN,Tenório F,Barradas PC

更新日期：2018-03-01 00:00:00

abstract：:Place navigation engrams acquired with intact brain can be retrieved with either eye and are stored in both hemispheres. The retrieval circuitry was examined by testing an overtrained rat under lidocaine inactivation of the hippocampus, visual cortex, and superior colliculus. Thirty-three hooded rats with implanted ca...

journal_title：Neurobiology of learning and memory

authors： Turner LF,Liu Z,Bures J

更新日期：1997-07-01 00:00:00

abstract：:The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lo...

journal_title：Neurobiology of learning and memory

authors： Freeman FM,Young IG

更新日期：2001-05-01 00:00:00

abstract：:We previously identified a set of 50 genes that were differentially transcribed in the hippocampal CA1 region of aged, learning-impaired rats compared to aged, superior learning animals during a Morris water maze paradigm. In the current study, we expressed three of these genes (Pctk1, Tcf12 and Ccnd1), which had show...

journal_title：Neurobiology of learning and memory

authors： Wu K,Li S,Bodhinathan K,Meyers C,Chen W,Campbell-Thompson M,McIntyre L,Foster TC,Muzyczka N,Kumar A

更新日期：2012-01-01 00:00:00

abstract：:Inappropriate defense-alerting reaction to fear is a common feature of neuropsychiatric diseases. Therefore, impairments in brain circuits, as well as in molecular pathways underlying the neurovegetative adjustments to fear may play an essential role on developing neuropsychiatric disorders. Here we tested the hypothe...

journal_title：Neurobiology of learning and memory

authors： Lazaroni TL,Bastos CP,Moraes MF,Santos RS,Pereira GS

更新日期：2016-01-01 00:00:00

abstract：:Rodents exhibit neophobia for novel tastes, demonstrated by an initial reluctance to drink novel-tasting, potentially-aversive solutions. Taste neophobia attenuates across days if the solution is not aversive, demonstrated by increased consumption as the solution becomes familiar. This attenuation of taste neophobia i...

journal_title：Neurobiology of learning and memory

authors： Grau-Perales AB,Levy ERJ,Fenton AA,Gallo M

更新日期：2019-01-01 00:00:00

abstract：:Agmatine is a new putative neurotransmitter; however, the physiological role(s) of this endogenous released polyamine is still to be determined. We investigated its cognitive effect in an inhibitory avoidance task in adult rats. Agmatine (0.1, 1, 10, and 20 mg/kg) or saline was administered ip immediately after traini...

journal_title：Neurobiology of learning and memory

authors： Arteni NS,Lavinsky D,Rodrigues AL,Frison VB,Netto CA

更新日期：2002-09-01 00:00:00

abstract：:Synaptic plasticity is subject to activity-dependent long-term modification (metaplasticity). We have recently described a novel form of heterosynaptic metaplasticity in hippocampal CA1, whereby 'priming' activity at one set of synapses confers a metaplastic state that inhibits subsequent LTP both within and between d...

journal_title：Neurobiology of learning and memory

authors： Jones OD,Hulme SR,Abraham WC

更新日期：2013-10-01 00:00:00

abstract：:The present experiments examined the effects of posttraining intra-dorsal striatal (i.e., caudate-putamen) injections of the phospholipid methylcarbamyl platelet-activating factor (mc-PAF) and the platelet-activating factor (PAF) antagonist BN 52021 on memory using a striatal-dependent cued water maze task. Male Long-...

journal_title：Neurobiology of learning and memory

authors： Packard MG,Teather LA,Bazan NG

更新日期：1996-09-01 00:00:00

abstract：:Environmental stimuli during neonatal periods play an important role in the development of cognitive function. In this study, we examined the long-term effects of neonatal tactile stimulation (TS) on spatial working memory (SWM) and related mechanisms. We also investigated whether TS-induced effects could be counterac...

journal_title：Neurobiology of learning and memory

authors： Zhang M,Cai JX

更新日期：2008-05-01 00:00:00

abstract：:The objective of the present study was to observe the effects of pre-training or post-training administration of dicyclomine, a M1 muscarinic antagonist, on inhibitory avoidance (IA) and contextual fear conditioning (CFC) and to investigate if the effects observed with the pre-training administration of dicyclomine ar...

journal_title：Neurobiology of learning and memory

authors： Soares JC,Fornari RV,Oliveira MG

更新日期：2006-09-01 00:00:00

abstract：:The dynamics of learning in the Active Avoidance test was analyzed at the trials level as well as at the level of daily sessions, each comprising numerous trials. The two scales (large scale for the sessions and small scale for the trials) were demonstrated to be mutually independent. The intermediate derived scales (...

journal_title：Neurobiology of learning and memory

authors： Giuliani A,Mancini AM,Ghirardi O,Ramacci MT,Voronina T,Sirabella P,Colosimo A

更新日期：1996-01-01 00:00:00

abstract：:Viral infection during early stage of life influences brain development and results in several neurodevelopmental disorders such as schizophrenia, autism and behavioral abnormalities. However, the mechanism through which infection causes long-term behavioral defects is not well known. To elucidate this, we have used s...

journal_title：Neurobiology of learning and memory

authors： Baghel MS,Singh B,Dhuriya YK,Shukla RK,Patro N,Khanna VK,Patro IK,Thakur MK

更新日期：2018-11-01 00:00:00

abstract：:Drug abuse, overeating, and smoking are all examples of instrumental behaviors that often involve chains or sequences of behavior. A behavior chain is minimally composed of a procurement response that is required in order for a subsequent consumption response to be reinforced. Despite the translational importance of b...

journal_title：Neurobiology of learning and memory

authors： Thrailkill EA,Bouton ME

更新日期：2016-09-01 00:00:00

abstract：:Neuroplastin 65 (NP65) is a brain-specific glycoprotein component of synaptic membrane, which is predominantly located in the forebrain such as the cortex, amygdala and striatum and hippocampus. Previous studies have shown that NP65 is implicated in synaptic plasticity, so it was hypothesized to play roles in cognitiv...

journal_title：Neurobiology of learning and memory

authors： Amuti S,Tang Y,Wu S,Liu L,Huang L,Zhang H,Li H,Jiang F,Wang G,Liu X,Yuan Q

更新日期：2016-01-01 00:00:00

abstract：:It is well established that neurons are plastic and can change the strength of their connections with other neurons depending on their recent history. While many molecular entities involved in plastic processes were already described, the role of a store-operated calcium channel ORAI1 in neuronal plasticity is not kno...

journal_title：Neurobiology of learning and memory

authors： Tshuva RY,Korkotian E,Segal M

更新日期：2017-04-01 00:00:00

abstract：:The neurosteroid pregnenolone (PREG) has been shown to have memory-enhancing and anti-depressant action. The present study addresses the question of whether intranasally applied pregnenolone (IN-PREG) also has promnestic properties in the rat. We examined the effects of IN-PREG at doses of 0.187 and 0.373mg/kg on memo...

journal_title：Neurobiology of learning and memory

authors： Abdel-Hafiz L,Chao OY,Huston JP,Nikolaus S,Spieler RE,de Souza Silva MA,Mattern C

更新日期：2016-09-01 00:00:00

abstract：:The present study examined the effects of posttraining ethanol administration upon retention of an appetitive task using a variety of retention behaviors associated with the task. Male C57BL/6J mice were individually trained to find a cheese pellet placed in the corner of an open field. Five behavioral measures were u...

journal_title：Neurobiology of learning and memory

authors： Ladner CJ,Babbini M,Davies DL,Parker ES,Alkana RL

更新日期：2001-01-01 00:00:00

abstract：:In the wild, house mice live in social groups, whereas in the laboratory male mice are often singly housed. Environmental enrichment such as that provided by social housing has been argued to improve the cognitive performance of laboratory animals in experimental tests. The aim of the present study was to test the cos...

journal_title：Neurobiology of learning and memory

authors： Fitchett AE,Collins SA,Barnard CJ,Cassaday HJ

更新日期：2005-11-01 00:00:00

abstract：:The present work shows that the dorsomedial telencephalic pallium of teleost fish, proposed as homologous to the amygdala of mammals, is involved in taste aversion learning (TAL). To analyze the behavioral properties of TAL in goldfish, in Experiment 1, we used a delayed procedure similar to that employed with mammals...

journal_title：Neurobiology of learning and memory

authors： Martín I,Gómez A,Salas C,Puerto A,Rodríguez F

更新日期：2011-09-01 00:00:00

abstract：:Epidemiological studies demonstrated association between head injury (HI) and the subsequent development of Alzheimer's disease (AD). Certain hallmarks of AD, e.g. amyloid-β (Aβ) containing deposits, may be found in patients following traumatic BI (TBI). Recent studies uncover the cellular prion protein, PrP(C), as a ...

journal_title：Neurobiology of learning and memory

authors： Bobkova NV,Medvinskaya NI,Kamynina AV,Aleksandrova IY,Nesterova IV,Samokhin AN,Koroev DO,Filatova MP,Nekrasov PV,Abramov AY,Leonov SV,Volpina OM

更新日期：2014-01-01 00:00:00

abstract：:Enriched environment (EE) has an important role in the development and plasticity of the brain. In this study, we investigated the maintenance of early EE exposure-induced changes of spatial sensitivity, and the possible underlying mechanisms of this maintenance. We found that, compared with the age-matched control, t...

journal_title：Neurobiology of learning and memory

authors： Cai R,Zhou X,Guo F,Xu J,Zhang J,Sun X

更新日期：2010-11-01 00:00:00

abstract：:When trained to peck a selected position in a sagittally-oriented series of identical food containers, and then required to generalize to an identical series rotated by 90°, chicks identify as correct only the target position from the left end, while choosing the right one at chance. Here we show that when accustomed ...

journal_title：Neurobiology of learning and memory

authors： Rugani R,Vallortigara G,Vallini B,Regolin L

更新日期：2011-03-01 00:00:00

abstract：:Fetal alcohol exposure in human and rodents produces a number of cognitive deficits including impairments in learning and memory. Recent evidence in our laboratory has shown that fetal alcohol-exposed (FAE) rats respond differently to systemic administration of cholinergic drugs when tested for vigilance and locomotor...

journal_title：Neurobiology of learning and memory

authors： Nagahara AH,Handa RJ

更新日期：1999-11-01 00:00:00

abstract：:Attempts were made to further analyze the role of 5-HT1A receptors in consolidation of learning by evaluating the role of these receptors in cognitively normal and impaired animals. The effects of post-training administration of 8-OH-DPAT and 5-HT1A receptor antagonists, WAY 100135, WAY 100635, and S-UH-301, plus the ...

journal_title：Neurobiology of learning and memory

authors： Meneses A,Hong E

更新日期：1999-03-01 00:00:00

abstract：:Formation of long-term memories requires coordinated gene expression, which can be regulated at transcriptional, post-transcriptional, and translational levels. Post-transcriptional stabilization and destabilization of mRNAs provides precise temporal and spatial regulation of gene expression, which is critical for con...

journal_title：Neurobiology of learning and memory

authors： Lee YS,Lee JA,Kaang BK

更新日期：2015-10-01 00:00:00

abstract：:Inactivation of the rodent medial prefrontal cortex (mPFC) and hippocampus or disconnection of the hippocampus from the mPFC produces deficits in spatial working memory tasks. Previous studies have shown that delay length determines the extent to which mPFC and hippocampus functionally interact, with both structures b...

journal_title：Neurobiology of learning and memory

authors： Layfield DM,Patel M,Hallock H,Griffin AL

更新日期：2015-11-01 00:00:00

abstract：:Non-selective inhibition of histone deacetylases (HDACs), enzymes that remove acetyl groups from histone core proteins, enhances cognition and NMDAR-dependent long-term potentiation at hippocampal CA3-CA1 synapses. It is not known whether this is a general mechanism by which HDACs modulate plasticity at other hippocam...

journal_title：Neurobiology of learning and memory

authors： Franklin AV,Rusche JR,McMahon LL

更新日期：2014-10-01 00:00:00

abstract：:Primary sensory cortices have been assumed to serve as stimulus analyzers while cognitive functions such as learning and memory have been allocated to "higher" cortical areas. However, the primary auditory cortex (A1) is now known to encode the acquired significance of sound as indicated by associatively-induced speci...

journal_title：Neurobiology of learning and memory

authors： Hui GK,Wong KL,Chavez CM,Leon MI,Robin KM,Weinberger NM

更新日期：2009-07-01 00:00:00