Heterodimerization of type II phytochromes in Arabidopsis.

abstract：:This presentation reviews Chandra's major contribution to the understanding of nearby galaxies. After a brief summary on significant advances in characterizing various types of discrete x-ray sources, the presentation focuses on the global hot gas in and around galaxies, especially normal ones like our own. The hot ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang QD

更新日期：2010-04-20 00:00:00

abstract：:The transcription factor SRY (sex-determining region)-box 2 (SOX2) is an important functional marker of neural precursor cells (NPCs) and plays a critical role in self-renewal and neuronal differentiation; however, the molecular mechanisms underlying its functions are poorly understood. Using human embryonic stem cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cimadamore F,Amador-Arjona A,Chen C,Huang CT,Terskikh AV

更新日期：2013-08-06 00:00:00

abstract：:Monosynaptic excitatory connections between cerebellar granule and Purkinje cells were studied in dissociated cell cultures, and identification of the transmitter and the postsynaptic receptor at this synapse was pharmacologically investigated. The presynaptic granule cell and the postsynaptic Purkinje cell were volta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirano T,Hagiwara S

更新日期：1988-02-01 00:00:00

abstract：:A target protein for nalidixic and oxolinic acids in Escherichia coli, the nalA gene product (Pnal), was purified to homogeneity as judged by gel electrophoresis, using an in vitro complementation assay. It is a dimer of identical 110,000-dalton subunits. A polypeptide of this molecular weight is uniquely induced by a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sugino A,Peebles CL,Kreuzer KN,Cozzarelli NR

更新日期：1977-11-01 00:00:00

abstract：:The regulation of protein function through ligand-induced conformational changes is crucial for many signal transduction processes. The binding of a ligand alters the delicate energy balance within the protein structure, eventually leading to such conformational changes. In this study, we elucidate the energetic and m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauer D,Merz DR,Pelz B,Theisen KE,Yacyshyn G,Mokranjac D,Dima RI,Rief M,Žoldák G

更新日期：2015-08-18 00:00:00

abstract：:A fraction of the unintegrated viral DNA that appears early after infection of mouse cells by Moloney leukemia virus is infectious. The infectivity could be deomonstrated by an XC plaque assay of the cells exposed to DNA co-precipitated with calcium phosphate. The number of plaques deriving from closed-circular, super...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smotkin D,Gianni AM,Rozenblatt S,Weinberg RA

更新日期：1975-12-01 00:00:00

abstract：:During endoplasmic reticulum-associated degradation, the multifunctional AAA ATPase p97 is part of a protein degradation complex. p97 associates via its N-terminal domain with various cofactors to recruit ubiquitinated substrates. It also interacts with alternative substrate-processing cofactors, such as Ufd2, Ufd3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Zhou X,Wang L,Li G,Schindelin H,Lennarz WJ

更新日期：2007-05-22 00:00:00

abstract：:Transgenic mice expressing the sequences coding for the envelope proteins of the hepatitis B virus (HBV) in the liver have been used as a model of the HBV chronic carrier state. We evaluated the possibility of inducing a specific immune response to the viral envelope antigens and thus potentially controlling chronic H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mancini M,Hadchouel M,Davis HL,Whalen RG,Tiollais P,Michel ML

更新日期：1996-10-29 00:00:00

abstract：:The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show that Pic, a class 2 SPATE protein produced b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Perez F,Wahid R,Faherty CS,Kolappaswamy K,Rodriguez L,Santiago A,Murphy E,Cross A,Sztein MB,Nataro JP

更新日期：2011-08-02 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:A simple method has been developed for fusing synaptic vesicles into spherical structures 20-50 micron in diameter. The method has been applied to purified cholinergic synaptic vesicles from Torpedo electric organ, and the membrane properties of these fused structures have been studied by the "cell"-attached version o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rahamimoff R,DeRiemer SA,Sakmann B,Stadler H,Yakir N

更新日期：1988-07-01 00:00:00

abstract：:Madagascar periwinkle (Catharanthus roseus) is the sole source of the anticancer drugs vinblastine and vincristine, bisindole alkaloids derived from the dimerization of the terpenoid indole alkaloids vindoline and catharanthine. Full elucidation of the biosynthetic pathways of these compounds is a prerequisite for met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liscombe DK,Usera AR,O'Connor SE

更新日期：2010-11-02 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disease in which genetic risk has been mapped to HLA, but precise allelic associations have been difficult to infer due to limitations in genotyping methodology. Mapping PD risk at highest possible resolution, we performed sequencing of 11 HLA genes in 1,597 PD cases and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hollenbach JA,Norman PJ,Creary LE,Damotte V,Montero-Martin G,Caillier S,Anderson KM,Misra MK,Nemat-Gorgani N,Osoegawa K,Santaniello A,Renschen A,Marin WM,Dandekar R,Parham P,Tanner CM,Hauser SL,Fernandez-Viña M,Oksenb

更新日期：2019-04-09 00:00:00

abstract：:A method is proposed for analyzing fast (10 μs) single-molecule rotation trajectories in F1 adenosinetriphosphatase ([Formula: see text]-ATPase). This method is based on the distribution of jumps in the rotation angle that occur in the transitions during the steps between subsequent catalytic dwells. The method is com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkán-Kacsó S,Le LQ,Zhu K,Su H,Marcus RA

更新日期：2019-12-17 00:00:00

abstract：:The clonal rat pituitary cell line GH4C1 expresses the genes for several voltage-dependent potassium channels including Kv1.5 and Kv1.4. Dexamethasone, a glucocorticoid agonist, induces a slowly inactivating potassium current in these cells but does not alter the amplitude of a rapidly inactivating component of potass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung S,Saal DB,Kaczmarek LK

更新日期：1995-06-20 00:00:00

abstract：:The accuracy of tail-anchored (TA) protein targeting to the endoplasmic reticulum (ER) depends on the Guided Entry of Tail-Anchored (Get) protein targeting machinery. The fate of TA proteins that become inappropriately inserted into other organelles, such as mitochondria, is unknown. Here, we identify Msp1, a conserve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okreglak V,Walter P

更新日期：2014-06-03 00:00:00

abstract：:Understanding mammalian spermatozoan development and the events surrounding fertilization has grown slowly, in part because of uncertainty about the number and identity of the cellular components involved. Determination of those transcripts expressed specifically by germ cells should provide an inclusive list of proba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schultz N,Hamra FK,Garbers DL

更新日期：2003-10-14 00:00:00

abstract：:The biosynthetic origin of the 10,000 molecular weight neurophysins, carriers of the peptide hormones oxytocin and vasopressin, has been studied by cell-free synthesis, Poly(A)-RNA was isolated from bovine hypothalamus and translated in a wheat germ system containing (35)S- or (3)H-labeled amino acids. A number of uni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giudice LC,Chaiken IM

更新日期：1979-08-01 00:00:00

abstract：:Neuronal remodeling is a fundamental process by which the brain responds to environmental influences, e.g., during stress. In the hippocampus, chronic stress causes retraction of dendrites in CA3 pyramidal neurons. We have recently identified the glycoprotein M6a as a stress-responsive gene in the hippocampal formatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alfonso J,Fernández ME,Cooper B,Flugge G,Frasch AC

更新日期：2005-11-22 00:00:00

abstract：:Protected areas are crucial for biodiversity conservation because they provide safe havens for species threatened by land-use change and resulting habitat loss. However, protected areas are only effective when they stop habitat loss within their boundaries, and are connected via corridors to other wild areas. The effe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radeloff VC,Stewart SI,Hawbaker TJ,Gimmi U,Pidgeon AM,Flather CH,Hammer RB,Helmers DP

更新日期：2010-01-12 00:00:00

abstract：:Faster aging is predicted in more active tissues and animals because of greater reactive oxygen species generation. Yet age-related cell loss is greater in less active cell types, such as type II muscle fibers. Mitochondrial uncoupling has been proposed as a mechanism that reduces reactive oxygen species production an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amara CE,Shankland EG,Jubrias SA,Marcinek DJ,Kushmerick MJ,Conley KE

更新日期：2007-01-16 00:00:00

abstract：:Increases in cytoplasmic free calcium ([Ca2+]i) can be induced in resting B cells either by a low molecular weight (12-kDa) B-cell growth factor (LMW-BCGF) or by crosslinking the B-cell antigen CD19 with monoclonal antibody (mAb). LMW-BCGF causes a slow [Ca2+]i increase in peripheral blood and tonsillar B cells but ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledbetter JA,Rabinovitch PS,June CH,Song CW,Clark EA,Uckun FM

更新日期：1988-03-01 00:00:00

abstract：:Blood vessels and nerves often follow parallel trajectories, suggesting that distal targets use common cues that induce vascularization and innervation. Netrins are secreted by the floor plate and attract commissural axons toward the midline of the neural tube. Here, we show that Netrin-1 is also a potent vascular mit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park KW,Crouse D,Lee M,Karnik SK,Sorensen LK,Murphy KJ,Kuo CJ,Li DY

更新日期：2004-11-16 00:00:00

abstract：:Immunoaffinity-purified interleukin 2 (IL2) stimulated proliferation of large but not small B cells. Stimulation was observed even when B cells were cultured at very low cell densities (3 X 10(4) per microwell containing 0.2 ml of medium). Addition of small numbers of purified splenic T cells did not enhance the IL2-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mond JJ,Thompson C,Finkelman FD,Farrar J,Schaefer M,Robb RJ

更新日期：1985-03-01 00:00:00

abstract：:Acute injury to the intestinal mucosa is a major dose-limiting complication of abdominal radiation therapy. We studied the role of the transcription factor NF-kappaB in protection against radiation-induced apoptosis in the intestinal epithelium in vivo. We use mice in which NF-kappaB signaling through IkappaB-kinase (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egan LJ,Eckmann L,Greten FR,Chae S,Li ZW,Myhre GM,Robine S,Karin M,Kagnoff MF

更新日期：2004-02-24 00:00:00

abstract：:We studied the coupled binding and folding of alpha-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structural distributions, and dynamics. Results reve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon AC,Gambin Y,Lemke EA,Deniz AA

更新日期：2009-04-07 00:00:00

abstract：:A mitochondrial gene from Saccharomyces cerevisiae encoding a hydrophobic membrane protein, subunit 8 of the F0/F1-type mitochondrial ATPase complex, has been functionally replaced by an artificial nuclear gene specifying an imported version of this protein. The experiments reported here utilized a multicopy expressio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nagley P,Farrell LB,Gearing DP,Nero D,Meltzer S,Devenish RJ

更新日期：1988-04-01 00:00:00

abstract：:Spatial organization of the binding sites for the priming substrate, the template DNA, and the transcription inhibitor rifampicin (Rif) in Escherichia coli RNA polymerase (EC 2.7.7.6) was probed with chimeric compounds in which Rif is covalently attached to a ribonucleotide. The compounds bind to RNA polymerase in bif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mustaev A,Zaychikov E,Severinov K,Kashlev M,Polyakov A,Nikiforov V,Goldfarb A

更新日期：1994-12-06 00:00:00

abstract：:A remarkable property of Ca2+ fluxes through the inositol 1,4,5-trisphosphate (InsP3)-gated Ca2+ channel is that successive increments of InsP3 induce repeated transient release of accumulated Ca2+. The initial aim of this study was to propose a model, based on hypotheses compatible with the current description of thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swillens S,Combettes L,Champeil P

更新日期：1994-10-11 00:00:00

abstract：:The satellite sequences (AGGGAG)(n) and Ty3/gypsy-like retrotransposons are known to localize at the barley centromeres. Using a gametocidal system, which induces chromosomal mutations in barley chromosomes added to common wheat, we obtained an isochromosome for the short arm of barley chromosome 7H (7HS) that lacked ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nasuda S,Hudakova S,Schubert I,Houben A,Endo TR

更新日期：2005-07-12 00:00:00