Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.

abstract：:Myelinated fibers can be demonstrated in thin unstained brain sections of freshly killed uninjected animals. With this method myelinated fibers stand out as clearly as in stained Weigert sections from formalin-fixed brains. Unstained unfixed sections can be viewed under ordinary light within minutes after death of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richter CP,Warner CL

更新日期：1974-03-01 00:00:00

abstract：:In polyandrous species, fathers benefit from attracting greater maternal investment toward their offspring at the expense of the offspring of other males, while mothers should usually allocate resources equally among offspring. This conflict can lead to an evolutionary arms race between the sexes, manifested through a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raunsgard A,Opedal ØH,Ekrem RK,Wright J,Bolstad GH,Armbruster WS,Pélabon C

更新日期：2018-11-06 00:00:00

abstract：:In all photosynthetic organisms, light energy is used to drive electrons from a donor chlorophyll species via a series of acceptors across a biological membrane. These light-induced electron-transfer processes display a remarkably high quantum efficiency, indicating a near-complete inhibition of unproductive charge re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makita H,Hastings G

更新日期：2017-08-29 00:00:00

abstract：:The mammalian target of rapamycin (mTOR) is a central regulator of cell growth and proliferation in response to growth factor and nutrient signaling. Consequently, this kinase is implicated in metabolic diseases including cancer and diabetes, so there is great interest in understanding the complete spectrum of mTOR-re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang BT,Ducker GS,Barczak AJ,Barbeau R,Erle DJ,Shokat KM

更新日期：2011-09-13 00:00:00

abstract：:Although soft devices (grippers, actuators, and elementary robots) are rapidly becoming an integral part of the broad field of robotics, autonomy for completely soft devices has only begun to be developed. Adaptation of conventional systems of control to soft devices requires hard valves and electronic controls. This ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Preston DJ,Rothemund P,Jiang HJ,Nemitz MP,Rawson J,Suo Z,Whitesides GM

更新日期：2019-04-16 00:00:00

abstract：:CD31 is an Ig-like molecule expressed by leukocytes and endothelial cells with an established role in the regulation of leukocyte trafficking. Despite genetic deletion of CD31 being associated with exacerbation of T cell-mediated autoimmunity, the contribution of this molecule to T-cell responses is largely unknown. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma L,Mauro C,Cornish GH,Chai JG,Coe D,Fu H,Patton D,Okkenhaug K,Franzoso G,Dyson J,Nourshargh S,Marelli-Berg FM

更新日期：2010-11-09 00:00:00

abstract：:Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little is known of the mechanisms underlying their regulation. Here we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biggs WH 3rd,Meisenhelder J,Hunter T,Cavenee WK,Arden KC

更新日期：1999-06-22 00:00:00

abstract：:Hepatitis C virus (HCV) is a global epidemic manifested mainly by chronic infection. One strategy that HCV employs to establish chronic infection is to use the viral Ser protease NS3/4A to cleave some unknown cellular targets involved in innate immunity. Here we show that the target of NS3/4A is the mitochondrial anti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li XD,Sun L,Seth RB,Pineda G,Chen ZJ

更新日期：2005-12-06 00:00:00

abstract：:Using a water-based prebiotic model of sugar synthesis involving glycolaldehyde self-condensation, we demonstrate that homochiral L-dipeptide catalysts lead to the stereospecific syntheses of tetroses. The asymmetric effect is largest for erythrose, which may reach a D-enantiomeric excess of >80% with L-Val-L-Val cata...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber AL,Pizzarello S

更新日期：2006-08-22 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease characterized by insulitis and islet β-cell loss. Thus, an effective therapy may require β-cell restoration and immune suppression. Currently, there is no treatment that can achieve both goals efficiently. We report here that GABA exerts antidiabetic effects by acting on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soltani N,Qiu H,Aleksic M,Glinka Y,Zhao F,Liu R,Li Y,Zhang N,Chakrabarti R,Ng T,Jin T,Zhang H,Lu WY,Feng ZP,Prud'homme GJ,Wang Q

更新日期：2011-07-12 00:00:00

abstract：:Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mann KM,Ward JM,Yew CC,Kovochich A,Dawson DW,Black MA,Brett BT,Sheetz TE,Dupuy AJ,Australian Pancreatic Cancer Genome Initiative.,Chang DK,Biankin AV,Waddell N,Kassahn KS,Grimmond SM,Rust AG,Adams DJ,Jenkins NA,Copela

更新日期：2012-04-17 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules are heterodimeric glycoproteins with one alpha and one beta polypeptide chain of similar molecular size. In this report, we describe the binding of an acetylated N-terminal peptide of myelin basic protein, [Ala4]MBP-(1-14), to purified individual alpha and beta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nag B,Wada HG,Deshpande SV,Passmore D,Kendrick T,Sharma SD,Clark BR,McConnell HM

更新日期：1993-02-15 00:00:00

abstract：:Colorectal cancer is the second leading cause of cancer-related deaths in the United States. Understanding the distinct genetic and epigenetic changes contributing to the establishment and growth of metastatic lesions is crucial for the development of novel therapeutic strategies. In a search for key regulators of col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rychahou PG,Kang J,Gulhati P,Doan HQ,Chen LA,Xiao SY,Chung DH,Evers BM

更新日期：2008-12-23 00:00:00

abstract：:Proactive policing, the strategic targeting of people or places to prevent crimes, is a well-studied tactic that is ubiquitous in modern law enforcement. A 2017 National Academies of Sciences report reviewed existing literature, entrenched in deterrence theory, and found evidence that proactive policing strategies can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Del Toro J,Lloyd T,Buchanan KS,Robins SJ,Bencharit LZ,Smiedt MG,Reddy KS,Pouget ER,Kerrison EM,Goff PA

更新日期：2019-04-23 00:00:00

abstract：:L-Asparaginase (EC 3.5.1.1) inhibited respiration in sensitive, but not resistant, lines of murine lymphoma 6C3HED. Glucose, in these tumor lines, was principally converted to lactate, and very little was oxidized in the citric acid cycle or hexose monophosphate shunt. The cells derived 70-80% of their respiratory CO(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavietes BB,Regan DH,Demopoulos HB

更新日期：1974-10-01 00:00:00

abstract：:Influenza is a paradigm for understanding viral infections. As an opportunistic pathogen exploiting the cellular endocytic machinery for infection, influenza is also a valuable model system for exploring the cell's constitutive endocytic pathway. We have studied the transport, acidification, and fusion of single influ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lakadamyali M,Rust MJ,Babcock HP,Zhuang X

更新日期：2003-08-05 00:00:00

abstract：:We report on the expression of thymidine kinase (tk) activity in synchronized populations of mouse cells that have been transformed to the tk+ phenotype with purified DNA from various sources or with metaphase chromosomes from human cells. The viral (herpes) tk gene is constitutively expressed but, in all other cases ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schlosser CA,Steglich C,deWet JR,Scheffler IE

更新日期：1981-02-01 00:00:00

abstract：:Ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) has been implicated in Parkinson's disease (PD) and is present in neurofibrillary tangles or Lewy bodies. However, the molecular basis for UCH-L1s involvement in proteinacious fibril formation is still elusive, especially in regard to the pathogenicity of the I93M muta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koharudin LM,Liu H,Di Maio R,Kodali RB,Graham SH,Gronenborn AM

更新日期：2010-04-13 00:00:00

abstract：:Studies of the fluorescence polarization of 1,6-diphenyl-1,3,5-hexatriene in membranes of normal, transformed, and revertant 3T3 cells allowed estimation of microviscosities (eta) of the lipid bilayers of these cells. Fluorescence polarization values observed with normal cells were significantly lower than those obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuchs P,Parola A,Robbins PW,Blout ER

更新日期：1975-09-01 00:00:00

abstract：:Few mechanisms are known that explain how transcription factors can adjust phenotypic outputs to accommodate differing environments. In Saccharomyces cerevisiae, the decision to mate or invade relies on environmental cues that converge on a shared transcription factor, Ste12. Specificity toward invasion occurs via Ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorrity MW,Cuperus JT,Carlisle JA,Fields S,Queitsch C

更新日期：2018-08-21 00:00:00

abstract：:Daily rhythmic processes are coordinated by circadian clocks, which are present in numerous central and peripheral tissues. In mammals, two circadian clocks, the food-entrainable oscillator (FEO) and methamphetamine-sensitive circadian oscillator (MASCO), are "black box" mysteries because their anatomical loci are unk...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pendergast JS,Oda GA,Niswender KD,Yamazaki S

更新日期：2012-08-28 00:00:00

abstract：:The past decade of scientific ocean drilling has revealed seemingly ubiquitous, slow-growing microbial life within a range of deep biosphere habitats. Integrated Ocean Drilling Program Expedition 337 expanded these studies by successfully coring Miocene-aged coal beds 2 km below the seafloor hypothesized to be "hot sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trembath-Reichert E,Morono Y,Ijiri A,Hoshino T,Dawson KS,Inagaki F,Orphan VJ

更新日期：2017-10-31 00:00:00

abstract：:The reproductive activity of Trypanosoma lewisi was strikingly enhanced and sometimes prolonged for 2 days when sublethal doses of adenine were given to rats. The drug was effective when given for 5 or 7 days in the diet and/or intraperitoneally, starting one or two days before infection through two days after infecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taliaferro WH,D'Alesandro PA

更新日期：1971-01-01 00:00:00

abstract：:Methanogenic archaea are major contributors to the global carbon cycle and were long thought to belong exclusively to the euryarchaeal phylum. Discovery of the methanogenesis gene cluster methyl-coenzyme M reductase (Mcr) in the Bathyarchaeota, and thereafter the Verstraetearchaeota, led to a paradigm shift, pushing b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berghuis BA,Yu FB,Schulz F,Blainey PC,Woyke T,Quake SR

更新日期：2019-03-12 00:00:00

abstract：:The concept of a charge density wave (CDW) permeates much of condensed matter physics and chemistry. CDWs have their origin rooted in the instability of a one-dimensional system described by Peierls. The extension of this concept to reduced dimensional systems has led to the concept of Fermi surface nesting (FSN), whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu X,Cao Y,Zhang J,Plummer EW,Guo J

更新日期：2015-02-24 00:00:00

abstract：:Chromosome segregation and mitotic exit are initiated by the 1.2-MDa ubiquitin ligase APC/C (anaphase-promoting complex/cyclosome) and its coactivator CDC20 (cell division cycle 20). To avoid chromosome missegregation, APC/C(CDC20) activation is tightly controlled. CDC20 only associates with APC/C in mitosis when APC/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiao R,Weissmann F,Yamaguchi M,Brown NG,VanderLinden R,Imre R,Jarvis MA,Brunner MR,Davidson IF,Litos G,Haselbach D,Mechtler K,Stark H,Schulman BA,Peters JM

更新日期：2016-05-10 00:00:00

abstract：:Arginine is an amino acid that serves as a substrate for nitric oxide synthase and arginase. As such, arginine has the potential to influence diverse fundamental processes in the lung. Here we report that the arginine transport protein, cationic amino acid transporter (CAT)2, has a critical role in regulating lung inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothenberg ME,Doepker MP,Lewkowich IP,Chiaramonte MG,Stringer KF,Finkelman FD,MacLeod CL,Ellies LG,Zimmermann N

更新日期：2006-10-03 00:00:00

abstract：:The pattern of antibody specificities in sera from patients with myasthenia gravis (MG) was determined by the ability of monoclonal antibodies against defined determinants on the acetylcholine receptor molecule to inhibit binding of the serum antibodies to receptor from human muscle. We found that MG patients produce ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzartos SJ,Seybold ME,Lindstrom JM

更新日期：1982-01-01 00:00:00

abstract：:Acquired resistance to androgen receptor (AR)-targeted therapies compels the development of novel treatment strategies for castration-resistant prostate cancer (CRPC). Here, we report a profound effect of endostatin on prostate cancer cells by efficient intracellular trafficking, direct interaction with AR, reduction ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee JH,Isayeva T,Larson MR,Sawant A,Cha HR,Chanda D,Chesnokov IN,Ponnazhagan S

更新日期：2015-02-03 00:00:00

abstract：:Stromal cell lines were established from canine long-term marrow cultures, cloned by limiting dilution, and maintained in stromal cell-conditioned medium. These cells grew adherent, maintained stable growth rate and morphology under standard conditions (in 20-30% conditioned medium; confluency, 70-90%), and supported ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huss R,Hong DS,McSweeney PA,Hoy CA,Deeg HJ

更新日期：1995-01-31 00:00:00