Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

abstract：:Cytoskeletal filaments assemble into dense parallel, antiparallel, or disordered networks, providing a complex environment for active cargo transport and positioning by molecular motors. The interplay between the network architecture and intrinsic motor properties clearly affects transport properties but remains poorl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richard M,Blanch-Mercader C,Ennomani H,Cao W,De La Cruz EM,Joanny JF,Jülicher F,Blanchoin L,Martin P

更新日期：2019-07-23 00:00:00

abstract：:Microarrays have enabled the determination of how thousands of genes are expressed to coordinate function within single organisms. Yet applications to natural or engineered communities where different organisms interact to produce complex properties are hampered by theoretical and technological limitations. Here we de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marcelino LA,Backman V,Donaldson A,Steadman C,Thompson JR,Preheim SP,Lien C,Lim E,Veneziano D,Polz MF

更新日期：2006-09-12 00:00:00

abstract：:Transcripts from mitochondrial (maxicircle) genes of kinetoplastid organisms undergo RNA editing characterized by a series of reactions that insert and delete uridine nucleotides within the sequence of the pre-mRNAs. Guide RNAs, which complement fully edited mRNAs, provide the information for the edited sequence by an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Göringer HU,Koslowsky DJ,Morales TH,Stuart K

更新日期：1994-03-01 00:00:00

abstract：:Elevated expression of the marORAB multiple antibiotic-resistance operon enhances the resistance of Escherichia coli to various medically significant antibiotics. Transcription of the operon is repressed in vivo by the marR-encoded protein, MarR, and derepressed by salicylate and certain antibiotics. The possibility t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin RG,Rosner JL

更新日期：1995-06-06 00:00:00

abstract：:Tsetse-transmitted African trypanosomes must develop into mammalian-infectious metacyclic cells in the fly's salivary glands (SGs) before transmission to a new host. The molecular mechanisms that underlie this developmental process, known as metacyclogenesis, are poorly understood. Blocking the few metacyclic parasite...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vigneron A,O'Neill MB,Weiss BL,Savage AF,Campbell OC,Kamhawi S,Valenzuela JG,Aksoy S

更新日期：2020-02-04 00:00:00

abstract：:An enconuclease activity that reacts with x-irradiated DNA is present in extracts of E. coli. By using centrifugal methods to monitor the conversion of the supercoiled, circular double-stranded DNA for phage phi-x-174 (replicative form) or PM2 to the relaxed circular form it was possible to quantitate the rate of radi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strniste GF,Wallace SS

更新日期：1975-06-01 00:00:00

abstract：:A 3- to 5-year cycle of vole abundances is a characteristic phenomenon in the ecology of northern regions, and their explanation stands as a central theoretical challenge in population ecology. Although many species of voles usually coexist and are in severe competition for food and breeding space, the role of intersp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen TF,Stenseth NC,Henttonen H,Tast J

更新日期：1999-02-02 00:00:00

abstract：:The transcription and processing of mitochondrial 21S rRNA in a petite strain of Saccharomyces cerevisiae has been examined by electron microscopic analysis of R-loop hybrids and by hybridization of labeled mitochondrial DNA probes to RNA transferred to diazobenzyloxymethyl paper. We have shown the presence of a large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merten S,Synenki RM,Locker J,Christianson T,Rabinowitz M

更新日期：1980-03-01 00:00:00

abstract：:A new model of an autoimmune disease of the neuromuscular junction was obtained by injection of acetylcholine receptor purified from rat denervated muscles into Balb/c mice. Anti-rat, then anti-mouse acetylcholine receptor antibodies, appear in mouse serum during the immunization procedure. Electrophysiological invest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Granato DA,Fulpius BW,Moody JF

更新日期：1976-08-01 00:00:00

abstract：:The magnetic circular dichroism of benzene and indole derivatives was measured down to 190 nM. The following pairs of molecules have magnetic circular dichroisms of the opposite sign in the B(2u) absorption region: aniline and benzonitrile, indene and indoline, indole and 4-aminoindole, and 4-aminoindole and 5-aminoin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Eyring H

更新日期：1973-12-01 00:00:00

abstract：:CTCF sites are abundant in the genomes of diverse species but their function is enigmatic. We used chromosome conformation capture to determine long-range interactions among CTCF/cohesin sites over 2 Mb on human chromosome 11 encompassing the beta-globin locus and flanking olfactory receptor genes. Although CTCF occup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hou C,Dale R,Dean A

更新日期：2010-02-23 00:00:00

abstract：:We have recently purified calorigen, the natural trigger for heat production in the inflorescences of Sauromatum guttatum Schott (voodoo lily), a thermogenic plant, and identified it as salicylic acid. Since then an analytical assay was developed that allows the quantitation of salicylic acid in plant tissues. This as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raskin I,Turner IM,Melander WR

更新日期：1989-04-01 00:00:00

abstract：:Fibroblasts can be reprogrammed to induced pluripotent stem cells (iPSCs) by application of transcription factors octamer-binding protein 4 (Oct4), SRY-box containing gene 2 (Sox2), Kruppel-like factor 4 (Klf4), and c-Myelocytomatosis oncogene (c-Myc) (OSKM), but the underlying mechanisms remain unclear. Here, we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang G,Guo X,Hong W,Liu Q,Wei T,Lu C,Gao L,Ye D,Zhou Y,Chen J,Wang J,Wu M,Liu H,Kang J

更新日期：2013-02-19 00:00:00

abstract：:Human Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, synaptic activity, and retinal homeostasis. Mutations in hBest1 cause the autosomal-dominant Best macular dystrophy (BMD). Because hBest1 mutations cause BMD, but a knockout does not, we wondered if hBest1 mutants...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bharill S,Fu Z,Palty R,Isacoff EY

更新日期：2014-04-29 00:00:00

abstract：:Supernumerary B chromosomes are optional additions to the basic set of A chromosomes, and occur in all eukaryotic groups. They differ from the basic complement in morphology, pairing behavior, and inheritance and are not required for normal growth and development. The current view is that B chromosomes are parasitic e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martis MM,Klemme S,Banaei-Moghaddam AM,Blattner FR,Macas J,Schmutzer T,Scholz U,Gundlach H,Wicker T,Šimková H,Novák P,Neumann P,Kubaláková M,Bauer E,Haseneyer G,Fuchs J,Doležel J,Stein N,Mayer KF,Houben A

更新日期：2012-08-14 00:00:00

abstract：:Mutations are introduced into rearranged Ig variable genes at a frequency of 10(-2) mutations per base pair by an unknown mechanism. Assuming that DNA repair pathways generate or remove mutations, the frequency and pattern of mutation will be different in variable genes from mice defective in repair. Therefore, hyperm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Winter DB,Phung QH,Umar A,Baker SM,Tarone RE,Tanaka K,Liskay RM,Kunkel TA,Bohr VA,Gearhart PJ

更新日期：1998-06-09 00:00:00

abstract：:Recent studies of human disease and transgenic animal experiments have clearly demonstrated the importance of desmosomes in normal tissue architecture. Furthermore, desmosomal components are down-regulated in certain types of carcinomas, suggesting a possible role for desmosomes in suppression of invasion and metastas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tselepis C,Chidgey M,North A,Garrod D

更新日期：1998-07-07 00:00:00

abstract：:We show that it is possible to direct particles entrained in a fluid along trajectories much like rays of light in classical optics. A microstructured, asymmetric post array forms the core hydrodynamic element and is used as a building block to construct microfluidic metamaterials and to demonstrate refractive, focusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton KJ,Loutherback K,Inglis DW,Tsui OK,Sturm JC,Chou SY,Austin RH

更新日期：2008-05-27 00:00:00

abstract：:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sachdeva V,Husain K,Sheng J,Wang S,Murugan A

更新日期：2020-06-09 00:00:00

abstract：:The patterns of variations in fisheries time series are known to result from a complex combination of species and fisheries dynamics all coupled with environmental forcing (including climate, trophic interactions, etc.). Disentangling the relative effects of these factors has been a major goal of fisheries science for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rouyer T,Fromentin JM,Ménard F,Cazelles B,Briand K,Pianet R,Planque B,Stenseth NC

更新日期：2008-04-08 00:00:00

abstract：:Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheinfeldt LB,Soi S,Tishkoff SA

更新日期：2010-05-11 00:00:00

abstract：:Campylobacter jejuni has a general N-linked glycosylation pathway (encoded by the pgl gene cluster), which culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac [where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover KJ,Weerapana E,Imperiali B

更新日期：2005-10-04 00:00:00

abstract：:There is a tightly coupled bidirectional interaction between visual cortex and visual thalamus [lateral geniculate nucleus (LGN)]. Using drifting sinusoidal grating stimuli, we compared the response of cells in the LGN with and without feedback from the visual cortex. Raster plots revealed a striking difference in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andolina IM,Jones HE,Wang W,Sillito AM

更新日期：2007-01-30 00:00:00

abstract：:The largest known DNA viruses infect Acanthamoeba and belong to two markedly different families. The Megaviridae exhibit pseudo-icosahedral virions up to 0.7 μm in diameter and adenine-thymine (AT)-rich genomes of up to 1.25 Mb encoding a thousand proteins. Like their Mimivirus prototype discovered 10 y ago, they enti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legendre M,Bartoli J,Shmakova L,Jeudy S,Labadie K,Adrait A,Lescot M,Poirot O,Bertaux L,Bruley C,Couté Y,Rivkina E,Abergel C,Claverie JM

更新日期：2014-03-18 00:00:00

abstract：:Type I Interferons (IFNs) are requisite components in antiviral innate immunity. Classically, a Toll-like receptor-dependent pathway induces type I interferons. However, recent recognition of melanoma differentiation associated gene-5 (MDA-5) and retinoic acid inducible gene-I (RIG-I) as primary sensors of RNA viruses...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar D,Desalle R,Fisher PB

更新日期：2008-11-04 00:00:00

abstract：:Inteins are intervening protein sequences that undergo self-excision from a precursor protein with concomitant joining of the flanking sequences. Here, we demonstrate intein trans-splicing in Nicotiana tabacum chloroplasts by using the naturally split Ssp DnaE intein. Trans-splicing occurred whether both intein fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin HG,Kim GD,Marin I,Mersha F,Evans TC Jr,Chen L,Xu MQ,Pradhan S

更新日期：2003-04-15 00:00:00

abstract：:Gene-environment interactions are important determinants of cancer risk. Traditionally, gene-environment interactions are thought to contribute to tumor-suppressor-gene penetrance by facilitating or inhibiting the acquisition of additional somatic mutations required for tumorigenesis. Here, we demonstrate that a disti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cook JD,Davis BJ,Cai SL,Barrett JC,Conti CJ,Walker CL

更新日期：2005-06-14 00:00:00

abstract：:Diverse motivations for preserving nature both inspire and hinder its conservation. Optimal conservation strategies may differ radically depending on the objective. For example, creating nature reserves may prevent extinctions through protecting severely threatened species, whereas incentivizing farmland hedgerows may...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karp DS,Mendenhall CD,Callaway E,Frishkoff LO,Kareiva PM,Ehrlich PR,Daily GC

更新日期：2015-09-01 00:00:00

abstract：:Molecular hybridization with (125)I-labeled citrus exocortis viroid RNA has been used to survey nucleic acid preparations from Gynura aurantiaca for viroid complementary molecules. A differential hybridization effect was detected between nucleic acid extracts from healthy and infected tissue in which significant RNase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grill LK,Semancik JS

更新日期：1978-02-01 00:00:00

abstract：:Selective inhibition of the intrinsic coagulation pathway is a promising strategy for developing safer anticoagulants that do not cause serious bleeding. Intrinsic tenase, the final and rate-limiting enzyme complex in the intrinsic coagulation pathway, is an attractive but less explored target for anticoagulants due t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao L,Wu M,Xiao C,Yang L,Zhou L,Gao N,Li Z,Chen J,Chen J,Liu J,Qin H,Zhao J

更新日期：2015-07-07 00:00:00