Abstract:
:Natural environments can present diverse challenges, but some genotypes remain fit across many environments. Such "generalists" can be hard to evolve, outcompeted by specialists fitter in any particular environment. Here, inspired by the search for broadly neutralizing antibodies during B cell affinity maturation, we demonstrate that environmental changes on an intermediate timescale can reliably evolve generalists, even when faster or slower environmental changes are unable to do so. We find that changing environments on timescales comparable with evolutionary transients in a population enhance the rate of evolving generalists from specialists, without enhancing the reverse process. The yield of generalists is further increased in more complex dynamic environments, such as a "chirp" of increasing frequency. Our work offers design principles for how nonequilibrium fitness "seascapes" can dynamically funnel populations to genotypes unobtainable in static environments.
journal_name
Proc Natl Acad Sci U S Aauthors
Sachdeva V,Husain K,Sheng J,Wang S,Murugan Adoi
10.1073/pnas.1914586117subject
Has Abstractpub_date
2020-06-09 00:00:00pages
12693-12699issue
23eissn
0027-8424issn
1091-6490pii
1914586117journal_volume
117pub_type
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