An embedded genus-one helicoid.

abstract：:The c-myc oncogene has been implicated in a wide spectrum of B-cell neoplasias. In normal cells, the level of expression of the c-myc gene correlates with growth status. In the present study, we examined the effect of receptor-mediated inhibition of growth on c-myc expression in a B-cell lymphoma. The murine lymphoma ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCormack JE,Pepe VH,Kent RB,Dean M,Marshak-Rothstein A,Sonenshein GE

更新日期：1984-09-01 00:00:00

abstract：:Substrate rigidity affects many physiological processes through mechanochemical signals from focal adhesion (FA) complexes that subsequently modulate gene expression. We find that shuttling of the LIM domain (domain discovered in the proteins, Lin11, Isl-1, and Mec-3) protein four-and-a-half LIM domains 2 (FHL2) betwe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakazawa N,Sathe AR,Shivashankar GV,Sheetz MP

更新日期：2016-11-01 00:00:00

abstract：:Skin wound infections are a significant health problem, and antibiotic resistance is on the rise. Mast cells (MCs) have been shown to contribute to host-defense responses in certain bacterial infections, but their role in skin wound superinfection is unknown. We subjected 2 MC-deficient mouse strains to Pseudomonas ae...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zimmermann C,Troeltzsch D,Giménez-Rivera VA,Galli SJ,Metz M,Maurer M,Siebenhaar F

更新日期：2019-10-08 00:00:00

abstract：:Immobilizing a protein, that is fully compatible with the patient, on the surface of a biomedical device should make it possible to avoid adverse responses such as inflammation, rejection, or excessive fibrosis. A surface that strongly binds and does not denature the compatible protein is required. Hydrophilic surface...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bilek MM,Bax DV,Kondyurin A,Yin Y,Nosworthy NJ,Fisher K,Waterhouse A,Weiss AS,dos Remedios CG,McKenzie DR

更新日期：2011-08-30 00:00:00

abstract：:It is generally acknowledged that cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4-deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4 weeks of birth, sug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verhagen J,Gabrysová L,Minaee S,Sabatos CA,Anderson G,Sharpe AH,Wraith DC

更新日期：2009-03-03 00:00:00

abstract：:Proteasome activator PA200 enhances proteasome-mediated cleavage after acidic residues in vitro; however, its role within cells is not known. Here, we show that, in response to ionizing radiation, PA200 forms hybrid proteasomes with 19S caps and 20S core proteasomes that accumulate on chromatin, leading to an increase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blickwedehl J,Agarwal M,Seong C,Pandita RK,Melendy T,Sung P,Pandita TK,Bangia N

更新日期：2008-10-21 00:00:00

abstract：:A single, modified nucleoside in Escherichia coli tRNA, 6-(3-methyl-2-butenylamino)-2-methyl-thio-9-beta-D-ribofuranosylpurine, has been desulfurized with Raney nickel to afford its probable biosynthetic precursor. The limitations of the reaction at the nucleoside and tRNA levels and its lack of inhibition of the amin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hecht SM,Kirkegaard LH,Bock RM

更新日期：1971-01-01 00:00:00

abstract：:We have reported previously that murine bone marrow-derived dendritic cells (DC) pulsed with whole tumor lysates can mediate potent antitumor immune responses both in vitro and in vivo. Because successful therapy was dependent on host immune T cells, we have now evaluated whether the systemic administration of the T c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu K,Fields RC,Giedlin M,Mulé JJ

更新日期：1999-03-02 00:00:00

abstract：:Activation of class II gene transcription may involve alleviation of transcription repression as well as stimulation of the assembly and function of the general RNA polymerase (RNAP) II transcription machinery. Here, we investigated whether activator-reversible transcription repression by NC2 (Dr1/DRAP1) contributes t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castaño E,Gross P,Wang Z,Roeder RG,Oelgeschläger T

更新日期：2000-06-20 00:00:00

abstract：:In the nervous system, glucocorticosteroid hormones play a major role during development and adult life. Myelin-forming cells are among the targets of glucocorticosteroids, which have been shown to promote myelination both in the central and peripheral nervous system. Glucocorticosteroid-stimulated gene transcription ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fonte C,Grenier J,Trousson A,Chauchereau A,Lahuna O,Baulieu EE,Schumacher M,Massaad C

更新日期：2005-10-04 00:00:00

abstract：:Nanometer-scale pores have demonstrated potential for the electrical detection, quantification, and characterization of molecules for biomedical applications and the chemical analysis of polymers. Despite extensive research in the nanopore sensing field, there is a paucity of theoretical models that incorporate the in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reiner JE,Kasianowicz JJ,Nablo BJ,Robertson JW

更新日期：2010-07-06 00:00:00

abstract：:The endoplasmic reticulum (ER)-mitochondria encounter structure (ERMES) comprises mitochondrial distribution and morphology 12 (Mdm12), maintenance of mitochondrial morphology 1 (Mmm1), Mdm34, and Mdm10 and mediates physical membrane contact sites and nonvesicular lipid trafficking between the ER and mitochondria in y...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong H,Park J,Jun Y,Lee C

更新日期：2017-11-07 00:00:00

abstract：:When the Mn(2+) and Ca(2+) ions normally present in concanavalin A are removed, the protein becomes incapable of binding saccharides. To explore the structural differences between the native and demetallized forms and their effects on the saccharide-binding properties of the protein, we have refined and compared the c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reeke GN Jr,Becker JW,Edelman GM

更新日期：1978-05-01 00:00:00

abstract：:We have isolated an Arabidopsis thaliana gene that codes for a receptor related to antifungal pathogenesis-related (PR) proteins. The PR5K gene codes for a predicted 665-amino acid polypeptide that comprises an extracellular domain related to the PR5 proteins, a central transmembrane-spanning domain, and an intracellu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Zafian P,Choudhary M,Lawton M

更新日期：1996-03-19 00:00:00

abstract：:Intracellular Ca(2+) release in many types of cells is mediated by ryanodine receptor Ca(2+) release channels (RyRCs) that are assembled into two-dimensional paracrystalline arrays in the endoplasmic/sarcoplasmic reticulum. However, the in situ operating mechanism of the RyRC array is unknown. Here, we found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang SQ,Stern MD,Ríos E,Cheng H

更新日期：2004-03-16 00:00:00

abstract：:A series of recombinant plasmids was generated in Escherichia coli in which the TEM beta-lactamase translocon (TnA) was inserted into the small plasmid RSF1010. RSF1010 is a 5.5 X 10(6) dalton nonconjugative plasmid which confers resistance to streptomycin and sulfonamide. The recombinant plasmids can be classified in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffron F,Rubens C,Falkow S

更新日期：1975-09-01 00:00:00

abstract：:Hereditary hemochromatosis (HH) is a common autosomal recessive disorder of iron metabolism that leads to excessive iron storage in the liver and other organs. Recently, between 83 and 100% of HH patients have been found to be homozygous for the same mutation in a novel major histocompatibility complex class I-like ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Parkkila S,Waheed A,Britton RS,Feder JN,Tsuchihashi Z,Schatzman RC,Bacon BR,Sly WS

更新日期：1997-03-18 00:00:00

abstract：:Antiviral and macrophage-priming activities in the supernatant medium of a subclone of a concanavalin A-stimulated mouse T-cell hybridoma were investigated. The two activities were associated with a molecular weight of approximately 50,000 and could not be separated by various approaches. Both activities were eliminat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pace JL,Russell SW,Schreiber RD,Altman A,Katz DH

更新日期：1983-06-01 00:00:00

abstract：:Ammonia oxidation to nitrite and its subsequent oxidation to nitrate provides energy to the two populations of nitrifying chemoautotrophs in the energy-starved dark ocean, driving a coupling between reduced inorganic nitrogen (N) pools and production of new organic carbon (C) in the dark ocean. However, the relationsh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Qin W,Hou L,Zakem EJ,Wan X,Zhao Z,Liu L,Hunt KA,Jiao N,Kao SJ,Tang K,Xie X,Shen J,Li Y,Chen M,Dai X,Liu C,Deng W,Dai M,Ingalls AE,Stahl DA,Herndl GJ

更新日期：2020-03-03 00:00:00

abstract：:Ceramide, a lipid mediator, has been most closely associated with antiproliferative activities. In this study, we examine the mechanism by which ceramide induces growth suppression and the role of the retinoblastoma gene product (Rb) in this process. Withdrawal of serum from the serum-dependent MOLT-4 cells resulted i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dbaibo GS,Pushkareva MY,Jayadev S,Schwarz JK,Horowitz JM,Obeid LM,Hannun YA

更新日期：1995-02-28 00:00:00

abstract：:Syringomycin, a peptide toxin and a virulence factor produced by the bacterial phytopathogen Pseudomonas syringae pv. syringae, stimulated the phosphorylation of several plasma membrane polypeptides of red beet storage tissue. Among these was a 100-kDa polypeptide, which corresponds in size to the proton pump ATPase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bidwai AP,Takemoto JY

更新日期：1987-10-01 00:00:00

abstract：:The structure of the antigen-binding fragment (Fab) of an anti-phenylarsonate monoclonal antibody (36-71) bearing a major crossreacting idiotype of A/J mice has been solved and refined to an R factor of 19.3% at a resolution of 2.9 A. An initial electron density map was obtained with phase information from a total of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rose DR,Strong RK,Margolies MN,Gefter ML,Petsko GA

更新日期：1990-01-01 00:00:00

abstract：:Overexpression of ErbB-2/Neu has been causally associated with mammary epithelial transformation. Here we report that blockade of the epidermal growth factor receptor (EGFR) kinase with AG-1478 markedly delays breast tumor formation in mouse mammary tumor virus (MMTV)/Neu + MMTV/transforming growth factor alpha bigeni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lenferink AE,Simpson JF,Shawver LK,Coffey RJ,Forbes JT,Arteaga CL

更新日期：2000-08-15 00:00:00

abstract：:A 60,000-dalton polypeptide (p60) has been identified in the feline leukemia virus (FeLV) pseudotype of Moloney sarcoma virus [MSV(FeLV)]. This polypeptide is present in the purified virus complex in concentrations greater than either the murine p30 or the feline p27. Purified p60 crossreacts immunologically with muri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oskarsson MK,Robey WG,Harris CL,Fischinger PJ,Haapala DK,Vande Woude GF

更新日期：1975-06-01 00:00:00

abstract：:Water freezing on solid surfaces is ubiquitous in nature. Even though icing/frosting impairs the performance and safety in many processes, its mechanism remains inadequately understood. Changing atmospheric conditions, surface properties, the complexity of icing physics, and the unorthodox behavior of water are the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung S,Tiwari MK,Poulikakos D

更新日期：2012-10-02 00:00:00

abstract：:It is well known that two regular tetrahedra can be combined with a single regular octahedron to tile (complete fill) three-dimensional Euclidean space . This structure was called the "octet truss" by Buckminster Fuller. It was believed that such a tiling, which is the Delaunay tessellation of the face-centered cubic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway JH,Jiao Y,Torquato S

更新日期：2011-07-05 00:00:00

abstract：:Dynamic coupling of blood supply with energy demand is a natural brain property that requires signaling between synapses and endothelial cells. Our previous work showed that cortical arteriole lumen diameter is regulated by N-methyl-d-aspartate receptors (NMDARs) expressed by brain endothelial cells. The purpose of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hogan-Cann AD,Lu P,Anderson CM

更新日期：2019-05-21 00:00:00

abstract：:The cytoskeleton provides structural integrity to cells and serves as a key component in mechanotransduction. Tensins are thought to provide a force-bearing linkage between integrins and the actin cytoskeleton; yet, direct evidence of tensin's role in mechanotransduction is lacking. We here report that local force app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheah JS,Jacobs KA,Heinrich V,Lo SH,Yamada S

更新日期：2019-10-01 00:00:00

abstract：:To investigate the contribution of interleukin-4 (IL-4) to airway inflammation in vivo and to explore directly its relationship to airway reactivity, we created transgenic mice in which the murine cDNA for IL-4 was regulated by the rat Clara cell 10 protein promoter. Expression was detected only in the lung and not in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rankin JA,Picarella DE,Geba GP,Temann UA,Prasad B,DiCosmo B,Tarallo A,Stripp B,Whitsett J,Flavell RA

更新日期：1996-07-23 00:00:00

abstract：:Protocell models are used to investigate how cells might have first assembled on Earth. Some, like oil-in-water droplets, can be seemingly simple models, while able to exhibit complex and unpredictable behaviors. How such simple oil-in-water systems can come together to yield complex and life-like behaviors remains a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Points LJ,Taylor JW,Grizou J,Donkers K,Cronin L

更新日期：2018-01-30 00:00:00