Abstract:
:We discuss the pulling force f required to extrude a lipid tube from a living cell as a function of the extrusion velocity L. The main feature is membrane friction on the cytoskeleton. As recently observed for neutrophils, the tether force exhibits a "shear thinning" response over a large range of pulling velocities, which was previously interpreted by assuming viscoelastic flows of the sliding membrane. Here, we propose an alternative explanation based on purely Newtonian flow: The diameter of the tether decreases concomitantly with the increase of the membrane tension in the lipid tube. The pulling force is found to vary as L(1/3), which is consistent with reported experimental data for various types of cells.
journal_name
Proc Natl Acad Sci U S Aauthors
Brochard-Wyart F,Borghi N,Cuvelier D,Nassoy Pdoi
10.1073/pnas.0602012103subject
Has Abstractpub_date
2006-05-16 00:00:00pages
7660-3issue
20eissn
0027-8424issn
1091-6490pii
0602012103journal_volume
103pub_type
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