Abstract:
:Visual deficits caused by abnormal visual experience during development are hard to recover in adult animals. Removal of chondroitin sulfate proteoglycans from the mature extracellular matrix with chondroitinase ABC promotes plasticity in the adult visual cortex. We tested whether chondroitinase ABC treatment of adult rats facilitates anatomical, functional, and behavioral recovery from the effects of a period of monocular deprivation initiated during the critical period for monocular deprivation. We found that chondroitinase ABC treatment coupled with reverse lid-suturing causes a complete recovery of ocular dominance, visual acuity, and dendritic spine density in adult rats. Thus, manipulations of the extracellular matrix can be used to promote functional recovery in the adult cortex.
journal_name
Proc Natl Acad Sci U S Aauthors
Pizzorusso T,Medini P,Landi S,Baldini S,Berardi N,Maffei Ldoi
10.1073/pnas.0602657103subject
Has Abstractpub_date
2006-05-30 00:00:00pages
8517-22issue
22eissn
0027-8424issn
1091-6490pii
0602657103journal_volume
103pub_type
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