ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes.

abstract：:Campylobacter jejuni is the leading cause of acute bacterial diarrhea worldwide and is implicated in development of Guillain-Barré syndrome. Two major surface features, the outer membrane lipooligosaccharide and flagella, are highly variable and are often targets for modification. Presumably, these modifications provi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cullen TW,Trent MS

更新日期：2010-03-16 00:00:00

abstract：:Asthma resistance to glucocorticoid treatment is a major health problem with unclear etiology. Glucocorticoids inhibit adrenal androgen production. However, androgens have potential benefits in asthma. HSD3B1 encodes for 3β-hydroxysteroid dehydrogenase-1 (3β-HSD1), which catalyzes peripheral conversion from adrenal de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zein J,Gaston B,Bazeley P,DeBoer MD,Igo RP Jr,Bleecker ER,Meyers D,Comhair S,Marozkina NV,Cotton C,Patel M,Alyamani M,Xu W,Busse WW,Calhoun WJ,Ortega V,Hawkins GA,Castro M,Chung KF,Fahy JV,Fitzpatrick AM,Israel

更新日期：2020-01-28 00:00:00

abstract：:During performance of attention-demanding cognitive tasks, certain regions of the brain routinely increase activity, whereas others routinely decrease activity. In this study, we investigate the extent to which this task-related dichotomy is represented intrinsically in the resting human brain through examination of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fox MD,Snyder AZ,Vincent JL,Corbetta M,Van Essen DC,Raichle ME

更新日期：2005-07-05 00:00:00

abstract：:25-Hydroxycholesterol is produced in mammalian tissues. The function of this oxysterol is unknown. Here we describe a central role for 25-hydroxycholesterol in regulating the immune system. In initial experiments, we found that stimulation of macrophage Toll-like receptors (TLR) induced expression of cholesterol 25-hy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bauman DR,Bitmansour AD,McDonald JG,Thompson BM,Liang G,Russell DW

更新日期：2009-09-29 00:00:00

abstract：:Amorphous silicon oxycarbide polymer-derived ceramics (PDCs), synthesized from organometallic precursors, contain carbon- and silica-rich nanodomains, the latter with extensive substitution of carbon for oxygen, linking Si-centered SiO(x)C(4-x) tetrahedra. Calorimetric studies demonstrated these PDCs to be thermodynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sen S,Widgeon SJ,Navrotsky A,Mera G,Tavakoli A,Ionescu E,Riedel R

更新日期：2013-10-01 00:00:00

abstract：:Repetitive brain stimulation protocols induce plasticity in the stimulated site in brain slice models. Recent evidence from network models has indicated that additional plasticity-related changes occur in nonstimulated remote regions. Despite increasing use of brain stimulation protocols in experimental and clinical s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abe M,Fukuyama H,Mima T

更新日期：2014-03-25 00:00:00

abstract：:The bacterial TATAAT -10 region sequence was the first promoter element to be identified, but how it functions is still not clear. Because the duplex element is melted during initiation, the effects of substitutions were studied in both single-and double-strand contexts. Band-shift results were particularly unexpected...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fenton MS,Gralla JD

更新日期：2001-07-31 00:00:00

abstract：:Arsenate is an abundant oxyanion that, because of its ability to mimic the phosphate group, is toxic to cells. Arsenate reductase (EC; encoded by the arsC gene in bacteria) participates to achieve arsenate resistance in both prokaryotes and yeast by reducing arsenate to arsenite; the arsenite is then exported by a spe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett MS,Guan Z,Laurberg M,Su XD

更新日期：2001-11-20 00:00:00

abstract：:Arabidopsis thaliana endosperm, a transient tissue that nourishes the embryo, exhibits extensive localized DNA demethylation on maternally inherited chromosomes. Demethylation mediates parent-of-origin-specific (imprinted) gene expression but is apparently unnecessary for the extensive accumulation of maternally biase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodrigues JA,Ruan R,Nishimura T,Sharma MK,Sharma R,Ronald PC,Fischer RL,Zilberman D

更新日期：2013-05-07 00:00:00

abstract：:Relative cerebral glucose metabolism was examined with positron-emission tomography (PET) as a measure of neuronal activation during performance of the classically conditioned eyeblink response in 12 young adult subjects. Each subject received three sessions: (i) a control session with PET scan in which unpaired prese...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Logan CG,Grafton ST

更新日期：1995-08-01 00:00:00

abstract：:The structural analysis of the Fab' fragment of human myeloma immunoglobulin IgGl(lambda) New has been extended to a nominal resolution of 2.0 A. Each of the structural subunits corresponding to the variable and to the constant homology regions of the light and heavy chains contains two irregular beta-sheets which are...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poljak RJ,Amzel LM,Chen BL,Phizackerley RP,Saul F

更新日期：1974-09-01 00:00:00

abstract：:Due to its remarkably long half-life, together with its wide in vivo distribution and its lack of enzymatic or immunological functions, human serum albumin (HSA) represents an optimal carrier for therapeutic peptides/proteins aimed at interacting with cellular or molecular components of the vascular and interstitial c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh P,Landais D,Lemaître M,Maury I,Crenne JY,Becquart J,Murry-Brelier A,Boucher F,Montay G,Fleer R

更新日期：1992-03-01 00:00:00

abstract：:The type II cell of the alveolar epithelium of adult rats has been studied by electron microscopy to determine its ability to endocytose electron-dense tracers of differing molecular charge and size. The tracers studied were native (anionic) ferritin, cationic ferritin, 70-kilodalton dextran, and colloidal carbon. Alv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams MC

更新日期：1984-10-01 00:00:00

abstract：:Immunoglobulin sequences were compared by using a technique that takes into account the dissimilarity in physicochemical properties of amino acids. Exterior residues showed greater structural variability than interior residues. High structural variability was found at positions known from crystallographic studies to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padlan EA

更新日期：1977-06-01 00:00:00

abstract：:The basal ganglia are critical for selecting actions and evaluating their outcome. Although the circuitry for selection is well understood, how these nuclei evaluate the outcome of actions is unknown. Here, we show in lamprey that a separate evaluation circuit, which regulates the habenula-projecting globus pallidus (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephenson-Jones M,Kardamakis AA,Robertson B,Grillner S

更新日期：2013-09-17 00:00:00

abstract：:Nature is rife with networks that are functionally optimized to propagate inputs to perform specific tasks. Whether via genetic evolution or dynamic adaptation, many networks create functionality by locally tuning interactions between nodes. Here we explore this behavior in two contexts: strain propagation in mechanic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rocks JW,Ronellenfitsch H,Liu AJ,Nagel SR,Katifori E

更新日期：2019-02-12 00:00:00

abstract：:Most studies of cytoskeletal organelles have concentrated on molecular analyses of abundant and biochemically accessible structures. In many of the classical cases, however, the nature of the system chosen has precluded a concurrent genetic analysis. The mitotic spindle of the yeast Saccharomyces cerevisiae is one exa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillus L,Solomon F

更新日期：1986-04-01 00:00:00

abstract：:Cryoelectron microscopy and X-ray crystallography have recently been used to generate structural models that likely represent the unliganded closed-channel conformation and the fully liganded open-channel conformation of different members of the nicotinic-receptor superfamily. To characterize the structure of the clos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Gutierrez G,Cuello LG,Nair SK,Grosman C

更新日期：2013-11-12 00:00:00

abstract：:Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation. By using immunohistochemical staining, we show that AQP5 expression in mouse lung is not restricted to type I cells, but is also detected in alveol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krane CM,Fortner CN,Hand AR,McGraw DW,Lorenz JN,Wert SE,Towne JE,Paul RJ,Whitsett JA,Menon AG

更新日期：2001-11-20 00:00:00

abstract：:We describe here the size and location of nephrin, the first protein to be identified at the glomerular podocyte slit diaphragm. In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruotsalainen V,Ljungberg P,Wartiovaara J,Lenkkeri U,Kestilä M,Jalanko H,Holmberg C,Tryggvason K

更新日期：1999-07-06 00:00:00

abstract：:Five DNA fragments have been cloned from yeast, chicken, and mouse DNA that titrate lac repressor in an Escherichia coli lac+ I+Z+ wild-type strain when on a multi-copy plasmid. The five repressor-binding sequences have been identified by DNA sequence determinations and DNase cleavage-inhibition patterns. They share t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simons A,Tils D,von Wilcken-Bergmann B,Müller-Hill B

更新日期：1984-03-01 00:00:00

abstract：:Loss or reduction in function of tumor suppressor genes contributes to tumorigenesis. Here, by allelic DNA copy number analysis using single-nucleotide polymorphism genotyping array and mass spectrometry, we report homozygous deletion in glioblastoma multiformes at chromosome 13q21, where DACH1 gene is located. We fou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe A,Ogiwara H,Ehata S,Mukasa A,Ishikawa S,Maeda D,Ueki K,Ino Y,Todo T,Yamada Y,Fukayama M,Saito N,Miyazono K,Aburatani H

更新日期：2011-07-26 00:00:00

abstract：:Preparations of partially purified chloroplast DNA-dependent RNA polymerase from maize and some other plants transcribe cloned chloroplast genes preferentially and much more actively from appropriately negatively supercoiled templates than from relaxed templates. We have found that the polymerase in such fractions doe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaitlin D,Hu J,Bogorad L

更新日期：1989-02-01 00:00:00

abstract：:The mitogenic neuropeptides bombesin and vasopressin markedly increased tyrosine and serine phosphorylation of multiple substrates in quiescent Swiss 3T3 fibroblasts, including two major bands of Mr 90,000 and 115,000. Tyrosine phosphorylation of these proteins was increased as judged by immunoprecipitation of 32Pi-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zachary I,Gil J,Lehmann W,Sinnett-Smith J,Rozengurt E

更新日期：1991-06-01 00:00:00

abstract：:BCL6 encodes a transcriptional repressor that is essential for the germinal center (GC) reaction and important in lymphomagenesis. Although its promoter has been well studied, little is known concerning its possible regulation by more distal elements. To gain such information, we mapped critical histone modifications ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandrareddy H,Bouska A,Shen Y,Ji M,Rizzino A,Chan WC,McKeithan TW

更新日期：2010-06-29 00:00:00

abstract：:Multiple-choice examinations play a critical role in university admissions across the world. A key question is whether imposing penalties for wrong answers on these examinations deters guessing from women more than men, disadvantaging female test-takers. We consider data from a large-scale, high-stakes policy change t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffman KB,Klinowski D

更新日期：2020-04-21 00:00:00

abstract：:Hapten coupled to isologous gamma globulin can substitute for anti-idiotypic antibody in the induction of neonatal chronic idiotype suppression. The immunologically suppressed animals fail to express an idiotypically defined subset of anti-hapten antibodies in later life and harbor regulatory T cells that prevent the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhisa T,Rajewsky K

更新日期：1985-06-01 00:00:00

abstract：:Osteogenin was recently purified and the amino acid sequences of tryptic peptides were determined. Osteogenin in conjunction with insoluble collagenous bone matrix induces cartilage and bone formation in vivo. To understand the mechanism of action of osteogenin, we examined its influence on periosteal cells, osteoblas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vukicevic S,Luyten FP,Reddi AH

更新日期：1989-11-01 00:00:00

abstract：:Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but Gln-tRNA is an exception to this rule. Gln-tRNA(Gln) is formed by this direct pathway in the eukaryotic cytosol and in protists or fungi mitochondria but is formed by an indirect transamidation pathwa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pujol C,Bailly M,Kern D,Maréchal-Drouard L,Becker H,Duchêne AM

更新日期：2008-04-29 00:00:00

abstract：:Amber suppressor tRNA genes were constructed by site-specific mutagenesis of the anticodons of human lysine-inserting tRNA (tRNA(Lys)) and glutamine-inserting tRNA (tRNA(Gln)) genes, and a Xenopus laevis tyrosine-inserting tRNA (tRNA(Tyr)) gene. As previous in vitro studies in prokaryotes have shown that substitution ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ho YS,Kan YW

更新日期：1987-04-01 00:00:00