Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.

abstract：:For the design of potent subunit vaccines, it is of paramount importance to identify all antigens immunologically recognized by a patient population infected with a pathogen. We have developed a rapid and efficient procedure to identify such commonly recognized antigens, and here we provide a comprehensive in vivo ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etz H,Minh DB,Henics T,Dryla A,Winkler B,Triska C,Boyd AP,Söllner J,Schmidt W,von Ahsen U,Buschle M,Gill SR,Kolonay J,Khalak H,Fraser CM,von Gabain A,Nagy E,Meinke A

更新日期：2002-05-14 00:00:00

abstract：:It has often been suggested that the frequently observed Watson-Crick base-pair compensatory substitutions in RNA helical structures occur mainly through a slightly deleterious G.U intermediate state. We have scored base substitutions in a set of 82 related Drosophila species for the D1 and D2 variable domains of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rousset F,Pélandakis M,Solignac M

更新日期：1991-11-15 00:00:00

abstract：:Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao T,Li W,Wang X,Xu H,Yang J,Wu Q,Huang Y,Geradts J,Jiang P,Fei T,Chi D,Zang C,Liao Q,Rennhack J,Andrechek E,Li N,Detre S,Dowsett M,Jeselsohn RM,Liu XS,Brown M

更新日期：2018-07-31 00:00:00

abstract：:A short, highly stereoselective (over 97%) synthesis of all-trans squalene is described. Starting with succinaldehyde, a tetraenedichlorodione having the complete squalene skeleton with the four internal trans olefinic bonds has been developed in four steps involving a sequence of two double Claisen rearrangements. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Werthemann L,Johnson WS

更新日期：1970-11-01 00:00:00

abstract：:We have produced a soluble form of a mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region of an immunoglobulin kappa light chain. These chimeric molecules composed of V alpha C alpha C kappa and V beta C beta C kappa chains were efficiently secreted (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grégoire C,Rebaï N,Schweisguth F,Necker A,Mazza G,Auphan N,Millward A,Schmitt-Verhulst AM,Malissen B

更新日期：1991-09-15 00:00:00

abstract：:Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4(+)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammarlund E,Dasgupta A,Pinilla C,Norori P,Früh K,Slifka MK

更新日期：2008-09-23 00:00:00

abstract：:The immunoglobulin light chain is thought to be organized into two structural domains, the constant and the variable regions, linked by a switch region of lesser tertiary organization. Light chains of homogeneous rabbit antibodies to pneumococcal polysaccharides labeled with (125)I were subjected to trypsin digestion ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poulsen K,Fraser KJ,Haber E

更新日期：1972-09-01 00:00:00

abstract：:The 26S proteasome, a molecular machine responsible for regulated protein degradation, consists of a proteolytic core particle (20S CP) associated with 19S regulatory particles (19S RPs) subdivided into base and lid subcomplexes. The assembly of 19S RP base subcomplex is mediated by multiple dedicated chaperones. Amon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrault MB,Richet N,Godard C,Murciano B,Le Tallec B,Rousseau E,Legrand P,Charbonnier JB,Le Du MH,Guérois R,Ochsenbein F,Peyroche A

更新日期：2012-04-24 00:00:00

abstract：:The S-M checkpoint delays mitosis until DNA replication is complete; cells defective in this checkpoint lose viability when DNA replication is inhibited. This inviability can be suppressed in fission yeast by overexpression of Cid1 or the related protein Cid13. Fission yeast contain six cid1/cid13-like genes, whereas ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Read RL,Martinho RG,Wang SW,Carr AM,Norbury CJ

更新日期：2002-09-17 00:00:00

abstract：:Vascular endothelial growth factor C (VEGF-C) recently has been described to be a relatively specific growth factor for the lymphatic vascular system. Here we report that ectopic application of recombinant VEGF-C also has potent angiogenic effects in vivo. VEGF-C is sufficiently potent to stimulate neovascularization ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Linden P,Farnebo J,Cao R,Eriksson A,Kumar V,Qi JH,Claesson-Welsh L,Alitalo K

更新日期：1998-11-24 00:00:00

abstract：:The activity of cullin-containing ubiquitin protein ligase complexes is stimulated by linkage to cullin of the ubiquitin-like protein Nedd8 ("neddylation"). Neddylation is inhibited by the tight binding of cullins to CAND1 (cullin-associated and neddylation-dissociated 1) protein, and Nedd8 is removed from cullins by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bornstein G,Ganoth D,Hershko A

更新日期：2006-08-01 00:00:00

abstract：:Complementary DNA (cDNA) clones encoding the adult human liver flavin-containing monooxygenase (FMO; dimethylaniline N-oxidase, EC 1.14.13.8) were isolated from lambda gt10 and lambda gt11 libraries. The cDNA libraries were screened with three synthetic 36-mer oligonucleotide probes derived from the nucleic acid seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lomri N,Gu Q,Cashman JR

更新日期：1992-03-01 00:00:00

abstract：:New advances in polarized light microscopy were used to image Congo red-stained cerebral amyloidosis in sharp relief. The rotating-polarizer method was used to separate the optical effects of transmission, linear birefringence, extinction, linear dichroism, and orientation of the electric dipole transition moments and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin LW,Claborn KA,Kurimoto M,Geday MA,Maezawa I,Sohraby F,Estrada M,Kaminksy W,Kahr B

更新日期：2003-12-23 00:00:00

abstract：:d-amino acids are present in some peptides from amphibian skin. These residues are derived from the corresponding L-amino acids present in the respective precursors. From skin secretions of Bombinae, we have isolated an enzyme that catalyzes the isomerization of an L-Ile in position 2 of a model peptide to D-allo-Ile....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jilek A,Mollay C,Tippelt C,Grassi J,Mignogna G,Müllegger J,Sander V,Fehrer C,Barra D,Kreil G

更新日期：2005-03-22 00:00:00

abstract：:Two precursors to Chinook salmon (Oncorhynchus tshawytscha) melanin-concentrating hormone, an important factor in teleosts involved in the control of skin pigmentation and stress responsiveness, have been identified from DNA sequence analysis. Both precursors encode proteins of 132 amino acids and they share 107/132 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minth CD,Qiu H,Akil H,Watson SJ,Dixon JE

更新日期：1989-06-01 00:00:00

abstract：:The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals that activate placebo effects. However, growing evidence suggest that behavior can be triggered by stimuli presented outside of co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jensen KB,Kaptchuk TJ,Kirsch I,Raicek J,Lindstrom KM,Berna C,Gollub RL,Ingvar M,Kong J

更新日期：2012-09-25 00:00:00

abstract：:Analysis, by the recovery of specific genetic "markers," of the effects of DNase I, physical shear, and temperature shock on DNA-cell complexes demonstrates that sequential attachment of both ends of bacteriophage SP82G DNA to Bacillus subtilis precedes entry of the DNA molecule into the cell, and that each attachment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams GL,Green DM

更新日期：1972-06-01 00:00:00

abstract：:Expressions are developed for weak single pair emission probability and strong emission average number of pairs. The water transparency cutoff is closely realized, showing that the fundamental time scale is even shorter. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwinger J

更新日期：1993-05-15 00:00:00

abstract：:The possibility that glycolate oxidation in unicellular green algae is linked to mitochondrial electron transport, rather than to peroxisomal metabolism as in higher plants and animals, was studied in a mutant of Chlamydomonas reinhardtii (dk97) deficient in cytochrome oxidase. This mutant had normal rates of dark res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Husic DW,Tolbert NE

更新日期：1987-03-01 00:00:00

abstract：:Current knowledge of the evolution of the postcranial skeleton in the genus Homo is hampered by a geographically and chronologically scattered fossil record. Here we present a complete characterization of the postcranium of the middle Pleistocene paleodeme from the Sima de los Huesos (SH) and its paleobiological impli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL,Carretero JM,Lorenzo C,Gómez-Olivencia A,Pablos A,Rodríguez L,García-González R,Bonmatí A,Quam RM,Pantoja-Pérez A,Martínez I,Aranburu A,Gracia-Téllez A,Poza-Rey E,Sala N,García N,Alcázar de Velasco A,Cuenca-B

更新日期：2015-09-15 00:00:00

abstract：:Voltage-gated sodium (Na(V)) and potassium (K(V)) channels are critical components of neuronal action potential generation and propagation. Here, we report that Na(V)β1 encoded by SCN1b, an integral subunit of Na(V) channels, coassembles with and modulates the biophysical properties of K(V)1 and K(V)7 channels, but no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen HM,Miyazaki H,Hoshi N,Smith BJ,Nukina N,Goldin AL,Chandy KG

更新日期：2012-11-06 00:00:00

abstract：:Inhibitory gamma-aminobutyric acid-mediated synaptic currents were studied in dissociated primary cultures of neonatal rat cortex with the whole-cell patch-clamp technique. Immunocytochemical staining of the cultures showed the presence of a large number of glutamic acid decarboxylase-containing neurons, and electrica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vicini S,Alho H,Costa E,Mienville JM,Santi MR,Vaccarino FM

更新日期：1986-12-01 00:00:00

abstract：:The mosquito midgut plays a central role in the sporogonic development of malaria parasites. We have found that polyclonal sera, produced against mosquito midguts, blocked the passage of Plasmodium falciparum ookinetes across the midgut, leading to a significant reduction of infections in mosquitoes. Anti-midgut mAbs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lal AA,Patterson PS,Sacci JB,Vaughan JA,Paul C,Collins WE,Wirtz RA,Azad AF

更新日期：2001-04-24 00:00:00

abstract：:Epstein-Barr virus (EBV) and Kaposi's sarcoma herpesvirus (KSHV) cause ∼2% of all human cancers. RNase R-resistant RNA sequencing revealed that both gammaherpesviruses encode multiple, uniquely stable, circular RNAs (circRNA). EBV abundantly expressed both exon-only and exon-intron circRNAs from the BamHI A rightward ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toptan T,Abere B,Nalesnik MA,Swerdlow SH,Ranganathan S,Lee N,Shair KH,Moore PS,Chang Y

更新日期：2018-09-11 00:00:00

abstract：:Protein-protein interactions allow the retinoid X receptor (RXR) to bind to cognate DNA as a homo- or a heterodimer and to participate in mediating the effects of a variety of hormones on gene transcription. Here we report a systematic study of the oligomeric state of RXR in the absence of a DNA template. We have used...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kersten S,Kelleher D,Chambon P,Gronemeyer H,Noy N

更新日期：1995-09-12 00:00:00

abstract：:The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). In fish, a PKR-like kinase activity has been detected, but the enzyme responsible has elude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothenburg S,Deigendesch N,Dittmar K,Koch-Nolte F,Haag F,Lowenhaupt K,Rich A

更新日期：2005-02-01 00:00:00

abstract：:Rhinoviruses (RVs) are the major causes of common colds in humans. They have a nonenveloped, icosahedral capsid surrounding a positive-strand RNA genome. Here we report that the antigen-binding (Fab) fragment of a neutralizing antibody (C5) can trigger genome release from RV-B14 to form emptied particles and neutraliz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dong Y,Liu Y,Jiang W,Smith TJ,Xu Z,Rossmann MG

更新日期：2017-07-25 00:00:00

abstract：:Using a novel technique of modulated photo-dissociation of carbon monoxide from hemoglobin, we have obtained the rates for conversion between the two quaternary states, R, and T, at 3-fold ligation. Our measurements at pH 7 and 22 degrees give rates of 780 +/- 40 sec-1 for going from R to T, and 2500 +/- 200 sec-1 fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrone FA,Hopfield JJ

更新日期：1976-12-01 00:00:00

abstract：:Proteolytic removal of the pre-segment from growing nascent chains of pre-human placental lactogen (hPL) occurred during in vitro translation of placental mRNA if crude membranes derived from ascites lysates, dog pancreas, or rat liver rough endoplasmic reticulum were added to the translation mixtures. The cotranslati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strauss AW,Zimmerman M,Boime I,Ashe B,Mumford RA,Alberts AW

更新日期：1979-09-01 00:00:00

abstract：:To study the protein structure-function relationship, we propose a method to efficiently create three-dimensional maps of structure space using a very large dataset of > 30,000 Structural Classification of Proteins (SCOP) domains. In our maps, each domain is represented by a point, and the distance between any two poi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osadchy M,Kolodny R

更新日期：2011-07-26 00:00:00