Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice.

abstract：:Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rif(r)) isolates were stable, suggesting that they had arisen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sánchez-Romero MA,Casadesús J

更新日期：2014-01-07 00:00:00

abstract：:Although mathematical models and laboratory experiments have shown that species interactions can generate chaos, field evidence of chaos in natural ecosystems is rare. We report on a pristine rocky intertidal community located in one of the world's oldest marine reserves that has displayed a complex cyclic succession ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benincà E,Ballantine B,Ellner SP,Huisman J

更新日期：2015-05-19 00:00:00

abstract：:Members of the polo subfamily of protein kinases play pivotal roles in cell-cycle control and proliferation. In addition to a high degree of sequence similarity in the kinase domain, polo kinases contain a strikingly conserved motif termed "polo-box" in the noncatalytic C-terminal domain. We have previously shown that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee KS,Song S,Erikson RL

更新日期：1999-12-07 00:00:00

abstract：:PIK3CA mutations are reported to be present in approximately 25% of breast cancer (BC), particularly the estrogen receptor-positive (ER+) and HER2-overexpressing (HER2+) subtypes, making them one of the most common genetic aberrations in BC. In experimental models, these mutations have been shown to activate AKT and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loi S,Haibe-Kains B,Majjaj S,Lallemand F,Durbecq V,Larsimont D,Gonzalez-Angulo AM,Pusztai L,Symmans WF,Bardelli A,Ellis P,Tutt AN,Gillett CE,Hennessy BT,Mills GB,Phillips WA,Piccart MJ,Speed TP,McArthur GA,Sotiriou

更新日期：2010-06-01 00:00:00

abstract：:Soret-excited resonance Raman spectroscopy yields direct information regarding the iron-carbon bonding interactions in the cyanomet and carbonmonoxy complexes of hemoglobin III from Chironomus thummi thummi (CTT III) in solution. By isotope exchange in cyanide (13CN-, C15N-, and 13C15N-) and carbon monoxide (13CO, C18...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu NT,Benko B,Kerr EA,Gersonde K

更新日期：1984-08-01 00:00:00

abstract：:cDNA fragments of the homologues of the Drosophila head homeotic genes labial (lab), proboscipedia (pb), and Deformed (Dfd) have been isolated from the crustacean Porcellio scaber. Because the accumulation domains of the head homeotic complex (Hox) genes had not been previously reported for crustaceans, we studied the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abzhanov A,Kaufman TC

更新日期：1999-08-31 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Park SH,Pantazides BG,Karpiuk O,Warren MD,Hardy CW,Duong DM,Park SJ,Kim HS,Vassilopoulos A,Seyfried NT,Johnsen SA,Gius D,Yu DS

更新日期：2013-08-13 00:00:00

abstract：:KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

更新日期：2021-02-09 00:00:00

abstract：:A sensitive test for kinetic unfolding intermediates in ribonuclease A (EC 3.1.27.5) is performed under conditions where the enzyme unfolds slowly (10 degrees C, pH 8.0, 4.5 M guanidinium chloride). Exchange of peptide NH protons (2H-1H) is used to monitor structural opening of individual hydrogen bonds during unfoldi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiefhaber T,Baldwin RL

更新日期：1995-03-28 00:00:00

abstract：:Photoperiodic control of testis growth in Passer domesticus (house sparrow) is mediated entirely by extraretinal photoreceptors in the brain. The eyes do not participate in photoperiodically significant photoreception. Removal of the pineal organ does not affect either the response to light or, to a first approximatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menaker M,Roberts R,Elliott J,Underwood H

更新日期：1970-09-01 00:00:00

abstract：:Activation-induced cytidine deaminase (AID) introduces single-strand breaks (SSBs) to initiate class switch recombination (CSR), gene conversion (GC), and somatic hypermutation (SHM). CSR is mediated by double-strand breaks (DSBs) at donor and acceptor switch (S) regions, followed by pairing of DSB ends in two S regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sabouri S,Kobayashi M,Begum NA,Xu J,Hirota K,Honjo T

更新日期：2014-02-11 00:00:00

abstract：:T-regulatory cells (Treg) and mast cells (MC) are abundant in colorectal cancer (CRC) tumors. Interaction between the two is known to promote immune suppression or loss of Treg functions and autoimmunity. Here, we demonstrate that in both human CRC and murine polyposis the outcome of this interaction is the generation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blatner NR,Bonertz A,Beckhove P,Cheon EC,Krantz SB,Strouch M,Weitz J,Koch M,Halverson AL,Bentrem DJ,Khazaie K

更新日期：2010-04-06 00:00:00

abstract：:The neotropical Heliconius butterflies are famous examples of Müllerian mimicry, due to the diverse array of shared, brightly colored wing patterns that advertise the butterflies' unpalatability. The parallel geographical variation in these patterns within several widespread species has been invoked to support the con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower AV

更新日期：1994-07-05 00:00:00

abstract：:Activins and inhibins, members of the type beta transforming growth factor superfamily of growth regulatory proteins, are produced in multiple tissues and affect diverse physiologic processes. Using embryonic stem cell technology, we previously demonstrated that inhibin can function as a gonadal tumor suppressor. In t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matzuk MM,Finegold MJ,Mather JP,Krummen L,Lu H,Bradley A

更新日期：1994-09-13 00:00:00

abstract：:RsbR is a regulator of sigma(B), the RNA polymerase sigma factor subunit responsible for transcribing the general stress response genes when environmental stress is imposed on Bacillus subtilis. The C-terminal domain of RsbR and its paralogues is a substrate for the kinase function of another sigma(B) regulator, RsbT,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray JW,Delumeau O,Lewis RJ

更新日期：2005-11-29 00:00:00

abstract：:The generation of high-titer, helper-free retroviruses by transient transfection has been achieved by using the highly transfectable 293T cell line into which are stably introduced constructs that express retroviral packaging functions. The resulting ecotropic virus packaging cell line BOSC 23 produces infectious retr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pear WS,Nolan GP,Scott ML,Baltimore D

更新日期：1993-09-15 00:00:00

abstract：:Several dual route models of human speech processing have been proposed suggesting a large-scale anatomical division between cortical regions that support motor-phonological aspects vs. lexical-semantic aspects of speech processing. However, to date, there is no complete agreement on what areas subserve each route or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridriksson J,Yourganov G,Bonilha L,Basilakos A,Den Ouden DB,Rorden C

更新日期：2016-12-27 00:00:00

abstract：:Although it has long been recognized that the enteric community of bacteria that inhabit the human distal intestinal track broadly impacts human health, the biochemical details that underlie these effects remain largely undefined. Here, we report a broad MS-based metabolomics study that demonstrates a surprisingly lar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wikoff WR,Anfora AT,Liu J,Schultz PG,Lesley SA,Peters EC,Siuzdak G

更新日期：2009-03-10 00:00:00

abstract：:The olivo-cerebellar network is a key neuronal circuit that provides high-level motor control in the vertebrate CNS. Functionally, its network dynamics is organized around the oscillatory membrane potential properties of inferior olive (IO) neurons and their electrotonic connectivity. Because IO action potentials are ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazantsev VB,Nekorkin VI,Makarenko VI,Llinás R

更新日期：2004-12-28 00:00:00

abstract：:Reactive oxygen species (ROS) mediate abscisic acid (ABA) signaling in guard cells. To dissect guard cell ABA-ROS signaling genetically, a cell type-specific functional genomics approach was used to identify 2 MAPK genes, MPK9 and MPK12, which are preferentially and highly expressed in guard cells. To provide genetic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jammes F,Song C,Shin D,Munemasa S,Takeda K,Gu D,Cho D,Lee S,Giordo R,Sritubtim S,Leonhardt N,Ellis BE,Murata Y,Kwak JM

更新日期：2009-12-01 00:00:00

abstract：:KRAS mutant tumors are largely recalcitrant to targeted therapies. Genetically engineered mouse models (GEMMs) of Kras mutant cancer recapitulate critical aspects of this disease and are widely used for preclinical validation of targets and therapies. Through comprehensive profiling of exomes and matched transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung WJ,Daemen A,Cheng JH,Long JE,Cooper JE,Wang BE,Tran C,Singh M,Gnad F,Modrusan Z,Foreman O,Junttila MR

更新日期：2017-12-19 00:00:00

abstract：:Prostaglandin E1 and the beta-adrenergic hormone l-isoproterenol stimulated cyclic AMP formation in both nucleated and enucleated myeloid leukemic cells that could be induced to differentiate normally to mature cells by the macrophage- and granulocyte-inducing protein MGI (MGI+D+ cells). Enucleated as well as nucleate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simantov R,Shkolnik T,Sachs L

更新日期：1980-08-01 00:00:00

abstract：:Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AM,Milner B,Petrides M,Evans AC

更新日期：1996-08-20 00:00:00

abstract：:The biotic recovery from Earth's most severe extinction event at the Permian-Triassic boundary largely reestablished the preextinction structure of marine trophic networks, with marine reptiles assuming the predator roles. However, the highest trophic level of today's marine ecosystems, i.e., macropredatory tetrapods ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fröbisch NB,Fröbisch J,Sander PM,Schmitz L,Rieppel O

更新日期：2013-01-22 00:00:00

abstract：:The double-stranded RNA (dsRNA)-dependent protein kinase (PKR) is induced as part of the IFN response in mammals and acts to shut down protein synthesis by the phosphorylation of eukaryotic initiation factor 2alpha (eIF2alpha). In fish, a PKR-like kinase activity has been detected, but the enzyme responsible has elude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothenburg S,Deigendesch N,Dittmar K,Koch-Nolte F,Haag F,Lowenhaupt K,Rich A

更新日期：2005-02-01 00:00:00

abstract：:After primary infection, human cytomegalovirus (HCMV) persists as a life-long latent infection, with host immunosuppression often resulting in clinical reactivation. During lytic infection, major changes in the expression of secreted cellular proteins (the secretome) occur that have profound effects on host-cell inter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mason GM,Poole E,Sissons JG,Wills MR,Sinclair JH

更新日期：2012-09-04 00:00:00

abstract：:Identifying the drivers and processes that determine globally the geographic range size of species is crucial to understanding the geographic distribution of biodiversity and further predicting the response of species to current global changes. However, these drivers and processes are still poorly understood, and no e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carvajal-Quintero J,Villalobos F,Oberdorff T,Grenouillet G,Brosse S,Hugueny B,Jézéquel C,Tedesco PA

更新日期：2019-07-02 00:00:00

abstract：:The mammary gland consists of an adipose tissue that, in a process called branching morphogenesis, is invaded by a ductal epithelial network comprising basal and luminal epithelial cells. Stem and progenitor cells drive mammary growth, and their proliferation is regulated by multiple extracellular cues. One of the key...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessenbrock K,Smith P,Steenbeek SC,Pervolarakis N,Kumar R,Minami Y,Goga A,Hinck L,Werb Z

更新日期：2017-03-21 00:00:00

abstract：:MicroRNAs (miRNAs) play essential, conserved roles in diverse developmental processes through association with the miRNA-induced silencing complex (miRISC). Whereas fundamental insights into the mechanistic framework of miRNA biogenesis and target gene silencing have been established, posttranslational modifications t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alessi AF,Khivansara V,Han T,Freeberg MA,Moresco JJ,Tu PG,Montoye E,Yates JR 3rd,Karp X,Kim JK

更新日期：2015-12-29 00:00:00

abstract：:Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance of oxidative stress. Cells lacking E2F1 are hypersensitive to oxidati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves JD,Lee YJ,Liu K,Li G,Lin FT,Lin WC

更新日期：2020-06-30 00:00:00