IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist.

abstract：:Transgenic mice expressing the Pim-1 kinase are predisposed to develop T-cell lymphomas with a long latency period of about 7-9 months. However, the exact functional basis of the oncogenic activity of Pim-1 remains obscure. C57BL/6 mice homozygous for the lpr mutation develop a well-described lymphoproliferative syndr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Möröy T,Grzeschiczek A,Petzold S,Hartmann KU

更新日期：1993-11-15 00:00:00

abstract：:Future nuclear arms reduction efforts will require technologies to verify that warheads slated for dismantlement are authentic without revealing any sensitive weapons design information to international inspectors. Despite several decades of research, no technology has met these requirements simultaneously. Recent wor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vavrek JR,Henderson BS,Danagoulian A

更新日期：2018-04-24 00:00:00

abstract：:The recently evolved Hawaiian species Drosophila silvestris has a subdivided population structure and shows great spatial heterogeneity in chromosome inversion distributions and frequencies within its extremely limited geographic range. Pattern analysis of the 11 chromosomal polymorphisms in the context of the recentl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craddock EM,Carson HL

更新日期：1989-06-01 00:00:00

abstract：:Acute and chronic injuries to the heart result in perturbation of intracellular calcium signaling, which leads to pathological cardiac hypertrophy and remodeling. Calcium/calmodulin-dependent protein kinase II (CaMKII) has been implicated in the transduction of calcium signals in the heart, but the specific isoforms o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Backs J,Backs T,Neef S,Kreusser MM,Lehmann LH,Patrick DM,Grueter CE,Qi X,Richardson JA,Hill JA,Katus HA,Bassel-Duby R,Maier LS,Olson EN

更新日期：2009-02-17 00:00:00

abstract：:We studied regional cerebral blood flow using the H2(15)O method while normal subjects performed four similar tasks involving three-letter word beginnings (stems). Prior to each task, subjects studied a list of words. Local blood flow was then monitored during a 40-sec period while subjects (i) silently viewed word st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Squire LR,Ojemann JG,Miezin FM,Petersen SE,Videen TO,Raichle ME

更新日期：1992-03-01 00:00:00

abstract：:The neighbor-exclusion principle is one of the most general and interesting rules describing intercalative DNA binding by small molecules. It suggests that such binding can only occur at every other base-pair site, reflecting a very large negative cooperativity in the binding process. We have carried out molecular mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao SN,Kollman PA

更新日期：1987-08-01 00:00:00

abstract：:Clinical research should conform to high standards of ethical and scientific integrity, given that human lives are at stake. However, economic incentives can generate conflicts of interest for investigators, who may be inclined to withhold unfavorable results or even tamper with data in order to achieve desired outcom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Adda J,Decker C,Ottaviani M

更新日期：2020-06-16 00:00:00

abstract：:Society places value on the multiple functions of ecosystems from soil fertility to erosion control to wildlife-carrying capacity, and these functions are potentially threatened by ongoing biodiversity losses. Recent empirically based models using individual species' traits suggest that higher species richness is requ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zavaleta ES,Pasari JR,Hulvey KB,Tilman GD

更新日期：2010-01-26 00:00:00

abstract：:One of the issues currently being debated in the ongoing discussion of the pros and cons of today's globalization concerns the effects of greater world trade as well as of the changes in technology on a country's internal distribution of income, especially on skilled versus unskilled wage rates. In this article, I att...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones RW

更新日期：2003-09-16 00:00:00

abstract：:We provide a framework for structural multiscale geometric organization of graphs and subsets of R(n). We use diffusion semigroups to generate multiscale geometries in order to organize and represent complex structures. We show that appropriately selected eigenfunctions or scaling functions of Markov matrices, which d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coifman RR,Lafon S,Lee AB,Maggioni M,Nadler B,Warner F,Zucker SW

更新日期：2005-05-24 00:00:00

abstract：:By indirect immunofluorescence techniques, microtubules and mitochondria were localized in normal rat kidney cells, human WI38 fibroblasts, mouse peritoneal macrophages, and a putative smooth muscle rat cell line, in monolayer culture. The mitochondria were found to be arranged along the cytoplasmic microtubules in ea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heggeness MH,Simon M,Singer SJ

更新日期：1978-08-01 00:00:00

abstract：:From within an albino melanocyte line grown in vitro we identified and cloned cells that apparently had reverted to wild type. We sequenced a part of the tyrosinase gene, encompassing a candidate mutation, from wild-type, albino, and revertant cell DNAs. The revertant cells contain, on one chromosome, a perfect base r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson IJ,Bennett DC

更新日期：1990-09-01 00:00:00

abstract：:Pyrimethamine (Pyr) targets dihydrofolate reductase of Plasmodium vivax (PvDHFR) as well as other malarial parasites, but its use as antimalarial is hampered by the widespread high resistance. Comparison of the crystal structures of PvDHFR from wild-type and the Pyr-resistant (SP21, Ser-58 --> Arg + Ser-117 --> Asn) s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kongsaeree P,Khongsuk P,Leartsakulpanich U,Chitnumsub P,Tarnchompoo B,Walkinshaw MD,Yuthavong Y

更新日期：2005-09-13 00:00:00

abstract：:3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is markedly elevated under several pathological conditions, including Huntington disease and human immunodeficiency virus infection. Here we demonstrate that micromolar concentrations (1-100 microM) of 3-HK cause cell death in primary neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okuda S,Nishiyama N,Saito H,Katsuki H

更新日期：1996-10-29 00:00:00

abstract：:How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin DM,Yang YH,Scolnick JA,Brunet LJ,Marsh H,Peng V,Okazaki Y,Hayashizaki Y,Speed TP,Ngai J

更新日期：2004-08-24 00:00:00

abstract：:In prokaryotes, in the absence of protein serine/threonine/tyrosine kinases, protein histidine kinases play a major role in signal transduction involved in cellular adaptation to various environmental changes and stresses. Histidine kinases phosphorylate their cognate response regulators at a specific aspartic acid re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park H,Saha SK,Inouye M

更新日期：1998-06-09 00:00:00

abstract：:In mitosis, chromosome, cytoskeleton, and organelle dynamics must be coordinated for successful cell division. Here, we present evidence for a role for Arf1, a small GTPase associated with the Golgi apparatus, in the orchestration of mitotic Golgi breakdown, chromosome segregation, and cytokinesis. We show that early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altan-Bonnet N,Phair RD,Polishchuk RS,Weigert R,Lippincott-Schwartz J

更新日期：2003-11-11 00:00:00

abstract：:SapB is a morphogenetic peptide that is important for aerial mycelium formation by the filamentous bacterium Streptomyces coelicolor. Production of SapB commences during aerial mycelium formation and depends on most of the genes known to be required for the morphogenesis of aerial hyphae. Furthermore, the application ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kodani S,Hudson ME,Durrant MC,Buttner MJ,Nodwell JR,Willey JM

更新日期：2004-08-03 00:00:00

abstract：:We have previously reported that in four transcription factor families the DNA-recognition rules can be described as (i) chemical rules, which list possible pairings between the 20 amino acid residues and the four DNA bases, and (ii) stereochemical rules, which describe the base and amino acid positions in contact. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki M,Yagi N

更新日期：1994-12-20 00:00:00

abstract：:A compact, well-organized, and natural motif, stabilized by three disulfide bonds, is proposed as a basic scaffold for protein engineering. This motif contains 37 amino acids only and is formed by a short helix on one face and an antiparallel triple-stranded beta-sheet on the opposite face. It has been adopted by scor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vita C,Roumestand C,Toma F,Ménez A

更新日期：1995-07-03 00:00:00

abstract：:We examine the IFN-alpha/beta-independent activation of cellular transcription that constitutes an early antiviral response of cells against influenza A and B viruses, which cause widespread epidemics in humans. We show that influenza B virus induces the synthesis in human cells of several mature mRNAs encoded by gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim MJ,Latham AG,Krug RM

更新日期：2002-07-23 00:00:00

abstract：:Many cells exhibit periodic transient increases in cytosolic calcium levels rather than a sustained rise when stimulated by a hormone or growth factor. We propose here a molecular model that accounts for periodic calcium spiking induced by a constant stimulus. Four elements give rise to repetitive calcium transients: ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer T,Stryer L

更新日期：1988-07-01 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:Twenty years after their discovery, knots in proteins are now quite well understood. They are believed to be functionally advantageous and provide extra stability to protein chains. In this work, we go one step further and search for links-entangled structures, more complex than knots, which consist of several compone...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabrowski-Tumanski P,Sulkowska JI

更新日期：2017-03-28 00:00:00

abstract：:We introduce a family of fast ordered upwind methods for approximating solutions to a wide class of static Hamilton-Jacobi equations with Dirichlet boundary conditions. Standard techniques often rely on iteration to converge to the solution of a discretized version of the partial differential equation. Our fast method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sethian JA,Vladimirsky A

更新日期：2001-09-25 00:00:00

abstract：:The relation between changes in brain and plasma concentrations of neurosteroids and the function and structure of gamma-aminobutyric acid type A (GABAA) receptors in the brain during pregnancy and after delivery was investigated in rats. In contrast with plasma, where all steroids increased in parallel, the kinetics ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Concas A,Mostallino MC,Porcu P,Follesa P,Barbaccia ML,Trabucchi M,Purdy RH,Grisenti P,Biggio G

更新日期：1998-10-27 00:00:00

abstract：:There are approximately 350 non-odorant G protein-coupled receptors (GPCRs) encoded by the human genome, many of which are predicted to be potential therapeutic targets, but there are only two structures available to represent the whole of the family. We hypothesized that improving the detergent stability of these rec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Serrano-Vega MJ,Magnani F,Shibata Y,Tate CG

更新日期：2008-01-22 00:00:00

abstract：:Induction of longstanding immunologic tolerance is essential for survival of transplanted organs and tissues. Despite recent advances in immunosuppression protocols, allograft damage inflicted by antibody specific for donor organs continues to represent a major obstacle to graft survival. Here we report that activatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi JY,Eskandari SK,Cai S,Sulkaj I,Assaker JP,Allos H,AlHaddad J,Muhsin SA,Alhussain E,Mansouri A,Yeung MY,Seelen MAJ,Kim HJ,Cantor H,Azzi JR

更新日期：2020-03-17 00:00:00

abstract：:LMB-7 [B3(Fv)-PE38] is a single-chain immunotoxin constructed from the murine monoclonal antibody B3 and a truncated from of Pseudomonas exotoxin PE38. Antibody B3 recognizes a carbohydrate epitope found on solid tumors that frequently invade the intrathecal space and cause neoplastic meningitis. We tested the therape...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pastan IH,Archer GE,McLendon RE,Friedman HS,Fuchs HE,Wang QC,Pai LH,Herndon J,Bigner DD

更新日期：1995-03-28 00:00:00

abstract：:In 2005 four outstanding multiple burials were discovered near Eulau, Germany. The 4,600-year-old graves contained groups of adults and children buried facing each other. Skeletal and artifactual evidence and the simultaneous interment of the individuals suggest the supposed families fell victim to a violent event. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haak W,Brandt G,de Jong HN,Meyer C,Ganslmeier R,Heyd V,Hawkesworth C,Pike AW,Meller H,Alt KW

更新日期：2008-11-25 00:00:00