Abstract:
:How olfactory sensory neurons converge on spatially invariant glomeruli in the olfactory bulb is largely unknown. In one model, olfactory sensory neurons interact with spatially restricted guidance cues in the bulb that orient and guide them to their target. Identifying differentially expressed molecules in the olfactory bulb has been extremely difficult, however, hindering a molecular analysis of convergence. Here, we describe several such genes that have been identified in a screen that compiled microarray data to create a three-dimensional model of gene expression within the mouse olfactory bulb. The expression patterns of these identified genes form the basis of a nascent spatial map of differential gene expression in the bulb.
journal_name
Proc Natl Acad Sci U S Aauthors
Lin DM,Yang YH,Scolnick JA,Brunet LJ,Marsh H,Peng V,Okazaki Y,Hayashizaki Y,Speed TP,Ngai Jdoi
10.1073/pnas.0404872101keywords:
subject
Has Abstractpub_date
2004-08-24 00:00:00pages
12718-23issue
34eissn
0027-8424issn
1091-6490pii
0404872101journal_volume
101pub_type
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