Isolation and characterization of muscle membranes using surface-specific labels.

abstract：:In the human, cone photoreceptors (L, M, and S) and the melanopsin-containing, intrinsically photosensitive retinal ganglion cells (ipRGCs) are active at daytime light intensities. Signals from cones are combined both additively and in opposition to create the perception of overall light and color. Similar mechanisms ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spitschan M,Jain S,Brainard DH,Aguirre GK

更新日期：2014-10-28 00:00:00

abstract：:In this model gravitation results from the emission and absorption of quanta (gravitons) that are scattered a few times in crossing a typical galaxy. Many features of the universe can be explained in terms of this model, although theoretical justification for the scattering of gravitons is lacking. Gravitons follow a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Britten RJ

更新日期：1992-05-01 00:00:00

abstract：:Bullvalene is a structurally unique dynamic molecule thought to interconvert among 1.2 million degenerate isomers. The incorporation of different chemical substituents onto the bullvalene core should lead to a "shape-shifting" molecule that can interconvert among thousands of discrete structural isomers. Previous NMR ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He M,Bode JW

更新日期：2011-09-06 00:00:00

abstract：:CCAAT/enhancer-binding protein δ (C/EBPδ) recently emerged as an essential player in the inflammatory response to bacterial infections. C/EBPδ levels increase rapidly after a proinflammatory stimulus, and increasing C/EBPδ levels seem to be indispensable for amplification of the inflammatory response. Here we aimed to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duitman J,Schouten M,Groot AP,Borensztajn KS,Daalhuisen JB,Florquin S,van der Poll T,Spek CA

更新日期：2012-06-05 00:00:00

abstract：:The mutation spectrum induced by the widely used antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP) showed that cisDDP[d(ApG)] adducts, although they account for only 25% of the lesions formed, are approximately 5 times more mutagenic than the major GG adduct. We report the construction of vectors bearing a sin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burnouf D,Gauthier C,Chottard JC,Fuchs RP

更新日期：1990-08-01 00:00:00

abstract：:Muscle plasminogen activators (PAs), such as urokinase-like PA and, to a lesser extent, tissue PA, increase dramatically after denervation induced by axotomy. The PA/plasmin system has also been implicated in degradation of specific components of the muscle fiber basement membrane after local activation of plasminogen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hantaï D,Rao JS,Festoff BW

更新日期：1990-04-01 00:00:00

abstract：:Euplotes raikovi of the wild-type strain 13 was found to be heterozygous (mat-1/mat-2) for the genetic locus mat, which is supposed to control the mating-type specificity of freely released mating pheromones ("euplomones"), and capable of yielding the two types of corresponding homozygotes (mat-1/mat-1, mat-2/mat-2). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luporini P,Raffioni S,Concetti A,Miceli C

更新日期：1986-05-01 00:00:00

abstract：:Nerve cells depend on specific interactions with glial cells for proper function. Myelinating glial cells are thought to associate with neuronal axons, in part, via the cell-surface adhesion protein, myelin-associated glycoprotein (MAG). MAG is also thought to be a major inhibitor of neurite outgrowth (axon regenerati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang LJ,Zeller CB,Shaper NL,Kiso M,Hasegawa A,Shapiro RE,Schnaar RL

更新日期：1996-01-23 00:00:00

abstract：:This communication reports a modulating effect of intracellular ATP on the steady-state and kinetic properties of the delayed rectifier of the giant axon of the squid. When internally dialyzed or perfused giant axons from Loligo plei or Loligo pealei are voltage clamped at -60 mV and washed free of ATP, the potassium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bezanilla F,Caputo C,DiPolo R,Rojas H

更新日期：1986-04-01 00:00:00

abstract：:The soil-transmitted helminths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that infect more than 1 billion of the poorest peoples and are leading causes of morbidity worldwide. Few anthelmintics are available for treatment, and only one is commonly used in mass drug administrations. New anthelminti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Y,Platzer EG,Bellier A,Aroian RV

更新日期：2010-03-30 00:00:00

abstract：:Gene expression networks are complicated by the assortment of regulatory factors that bind DNA and modulate transcription combinatorially. Single-cell measurements can reveal biological mechanisms hidden by population averages, but their value has not been fully explored in the context of mRNA regulation. Here, we ada...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Brugge JS,Janes KA

更新日期：2011-10-04 00:00:00

abstract：:Novel antibiotics are urgently needed to combat multidrug-resistant pathogens. Venoms represent previously untapped sources of novel drugs. Here we repurposed mastoparan-L, the toxic active principle derived from the venom of the wasp Vespula lewisii, into synthetic antimicrobials. We engineered within its N terminus ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva ON,Torres MDT,Cao J,Alves ESF,Rodrigues LV,Resende JM,Lião LM,Porto WF,Fensterseifer ICM,Lu TK,Franco OL,de la Fuente-Nunez C

更新日期：2020-10-27 00:00:00

abstract：:Guamanian amyotrophic lateral sclerosis (ALS-G) and parkinsonism dementia (PD-G) have been epidemiologically linked to an environment severely deficient in calcium (Ca2+) and magnesium (Mg2+). Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein containing both channel and kinase domains that ha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hermosura MC,Nayakanti H,Dorovkov MV,Calderon FR,Ryazanov AG,Haymer DS,Garruto RM

更新日期：2005-08-09 00:00:00

abstract：:The results of electron-nuclear double resonance and electron paramagnetic resonance (EPR) studies on the hydrogen peroxide compound of yeast cytochrome c peroxidase are inconsistent with previous proposals for the source of the EPR signal in this compound, in particular with its identification with an aromatic amino ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman BM,Roberts JE,Brown TG,Kang CH,Margoliash E

更新日期：1979-12-01 00:00:00

abstract：:Synthetic radionuclides, such as the transuranic actinides plutonium, americium, and curium, present severe health threats as contaminants, and understanding the scope of the biochemical interactions involved in actinide transport is instrumental in managing human contamination. Here we show that siderocalin, a mammal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allred BE,Rupert PB,Gauny SS,An DD,Ralston CY,Sturzbecher-Hoehne M,Strong RK,Abergel RJ

更新日期：2015-08-18 00:00:00

abstract：:In this study we sought to better understand the role of the glycoprotein quality control machinery in the assembly of MHC class I molecules with high-affinity peptides. The lectin-like chaperone calreticulin (CRT) and the thiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wearsch PA,Peaper DR,Cresswell P

更新日期：2011-03-22 00:00:00

abstract：:AvrXa7 is a member of the avrBs3 avirulence gene family, which encodes proteins targeted to plant cells by a type III secretion apparatus. AvrXa7, the product of avrXa7, is also a virulence factor in strain PXO86 of Xanthomonas oryzae pv. oryzae. Avirulence and virulence specificities are associated with the central r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang B,Zhu W,Johnson LB,White FF

更新日期：2000-08-15 00:00:00

abstract：:Plasma levels of corticosterone are often used as a measure of "stress" in wild animal populations. However, we lack conclusive evidence that different stress levels reflect different survival probabilities between populations. Galápagos marine iguanas offer an ideal test case because island populations are affected d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Romero LM,Wikelski M

更新日期：2001-06-19 00:00:00

abstract：:Glucose entry, as measured by 5-min uptake into the acid-soluble fraction, is enhanced 15-30 times by long-term (12-24 hr) hexose starvation of chick fibroblasts. The rate of galactose accumulation in the cells increases only 5 times under the same conditions of starvation. Several carbon and energy sources that were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martineau R,Kohlbacher M,Shaw SN,Amos H

更新日期：1972-11-01 00:00:00

abstract：:A core operation in speech production is the preparation of words from a semantic base. The theory of lexical access reviewed in this article covers a sequence of processing stages beginning with the speaker's focusing on a target concept and ending with the initiation of articulation. The initial stages of preparatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levelt WJ

更新日期：2001-11-06 00:00:00

abstract：:Variants of A/PR/8/34 (HON1) influenza virus, having hemagglutinin molecules with probably a single altered antigenic determinant, were isolated by growing the virus in the presence of the monoclonal hybridoma antibody PEG-1. The variants were analyzed by peptide mapping and characterized antigenically by using PEG-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laver WG,Gerhard W,Webster RG,Frankel ME,Air GM

更新日期：1979-03-01 00:00:00

abstract：:The increasing frequency of antibiotic resistance in hospital-acquired infections is a major public health concern that has both biological and economic causes. Here we develop conceptual mathematical models that couple the economic incentives and population biology of hospital infection control (HIC). We show that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DL,Levin SA,Laxminarayan R

更新日期：2005-02-22 00:00:00

abstract：:The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanekiyo T,Ban T,Aritake K,Huang ZL,Qu WM,Okazaki I,Mohri I,Murayama S,Ozono K,Taniike M,Goto Y,Urade Y

更新日期：2007-04-10 00:00:00

abstract：:Chlamydia trachomatis R2c is the prototype for a recently discovered group of ribonucleotide reductase R2 proteins that use a heterodinuclear Mn/Fe redox cofactor for radical generation and storage. Here, we show that the Mycobacterium tuberculosis protein Rv0233, an R2 homologue and a potential virulence factor, cont...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andersson CS,Högbom M

更新日期：2009-04-07 00:00:00

abstract：:The dissociation and association of an immobilized preparation of the octameric enzyme porphobilinogen synthase [5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing), EC 4.2.1.24] is described. On treatment of the immobilized preparation with 4 M urea, four subunits per octamer are removed which can ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gurne D,Chen J,Shemin D

更新日期：1977-04-01 00:00:00

abstract：:Previous work has shown that the kinetoplast minicircle DNA of Leishmania species exhibits species-specific sequence divergence and this observation has led to the development of a DNA probe-based diagnostic test for leishmaniasis. In the work reported here, we demonstrate that the minicircle is composed of three type...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers WO,Wirth DF

更新日期：1987-01-01 00:00:00

abstract：:The memory for a new episode is formed immediately upon experience and can last up to a lifetime. It has been shown that the hippocampal network plays a fundamental role in the rapid acquisition of a memory of a one-time experience, in which the novelty component of the experience promotes the prompt formation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagatsuma A,Okuyama T,Sun C,Smith LM,Abe K,Tonegawa S

更新日期：2018-01-09 00:00:00

abstract：:Quantitative immunohistochemical analysis of the sphenopalatine ganglion in normal cats revealed that virtually all ganglion cells (98.5%) were immunoreactive to vasoactive intestinal polypeptide (VIP). After surgical removal of this ganglion, the content of both VIP and choline acetyltransferase (acetyl-CoA:choline O...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Anggård A,Emson P,Fahrenkrug J,Hökfelt T

更新日期：1981-08-01 00:00:00

abstract：:Cerebral malaria is the most deadly manifestation of infection with Plasmodium falciparum. The pathology of cerebral malaria is characterized by the accumulation of infected erythrocytes (IEs) in the microvasculature of the brain caused by parasite adhesins on the surface of IEs binding to human receptors on microvasc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Claessens A,Adams Y,Ghumra A,Lindergard G,Buchan CC,Andisi C,Bull PC,Mok S,Gupta AP,Wang CW,Turner L,Arman M,Raza A,Bozdech Z,Rowe JA

更新日期：2012-06-26 00:00:00

abstract：:Cell membrane proteins synthesized after infection of Escherichia coli B with wild-type phage T4 and rIIA mutants were analyzed by dodecyl sulfate-polyacrylamide gel electrophoresis. A protein with an approximate molecular weight of 74,000 is present in membranes isolated from T4r(+)-infected cells, but is not found i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ennis HL,Kievitt KD

更新日期：1973-05-01 00:00:00