Integrated logic circuits using single-atom transistors.

Abstract:

:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. Single-atom transistors, SATs, cascaded in a circuit are proposed as a promising route that is compatible with existing technology. We demonstrate the use of quantum degrees of freedom to perform logic operations in a complementary-metal-oxide-semiconductor device. Each SAT performs multilevel logic by electrically addressing the electronic states of a dopant atom. A single electron transistor decodes the physical multivalued output into the conventional binary output. A robust scalable circuit of two concatenated full adders is reported, where by utilizing charge and quantum degrees of freedom, the functionality of the transistor is pushed far beyond that of a simple switch.

authors

Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

doi

10.1073/pnas.1109935108

subject

Has Abstract

pub_date

2011-08-23 00:00:00

pages

13969-72

issue

34

eissn

0027-8424

issn

1091-6490

pii

1109935108

journal_volume

108

pub_type

杂志文章
  • Modification of RelA by O-linked N-acetylglucosamine links glucose metabolism to NF-κB acetylation and transcription.

    abstract::The molecular mechanisms linking glucose metabolism with active transcription remain undercharacterized in mammalian cells. Using nuclear factor-κB (NF-κB) as a glucose-responsive transcription factor, we show that cells use the hexosamine biosynthesis pathway and O-linked β-N-acetylglucosamine (O-GlcNAc) transferase ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1208468109

    authors: Allison DF,Wamsley JJ,Kumar M,Li D,Gray LG,Hart GW,Jones DR,Mayo MW

    更新日期:2012-10-16 00:00:00

  • Natural language indicators of differential gene regulation in the human immune system.

    abstract::Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1707373114

    authors: Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

    更新日期:2017-11-21 00:00:00

  • Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.

    abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is an emerging cause of catheter-associated urinary tract infection (CAUTI), which frequently progresses to more serious invasive infections. We adapted a mouse model of CAUTI to investigate how catheterization increases an individual's susceptibility to MRSA UTI. Thi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1707572114

    authors: Walker JN,Flores-Mireles AL,Pinkner CL,Schreiber HL 4th,Joens MS,Park AM,Potretzke AM,Bauman TM,Pinkner JS,Fitzpatrick JAJ,Desai A,Caparon MG,Hultgren SJ

    更新日期:2017-10-10 00:00:00

  • Extremely high-gain source-gated transistors.

    abstract::Despite being a fundamental electronic component for over 70 years, it is still possible to develop different transistor designs, including the addition of a diode-like Schottky source electrode to thin-film transistors. The discovery of a dependence of the source barrier height on the semiconductor thickness and deri...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1820756116

    authors: Zhang J,Wilson J,Auton G,Wang Y,Xu M,Xin Q,Song A

    更新日期:2019-03-12 00:00:00

  • Deactivation kinetics of acid-sensing ion channel 1a are strongly pH-sensitive.

    abstract::Acid-sensing ion channels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological range. Recent reports have revealed that postsynaptically localized ASICs contribute to the excitatory postsynaptic current by responding to the transient acidification of the synaptic cleft that acco...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1620508114

    authors: MacLean DM,Jayaraman V

    更新日期:2017-03-21 00:00:00

  • A far-red fluorescent protein with fast maturation and reduced oligomerization tendency from Entacmaea quadricolor (Anthozoa, Actinaria).

    abstract::We performed the biochemical and biophysical characterization of a red fluorescent protein, eqFP611, from the sea anemone Entacmaea quadricolor cloned in Escherichia coli. With an excitation maximum at 559 nm and an emission maximum at 611 nm, the recombinant protein shows the most red-shifted emission and the largest...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.182157199

    authors: Wiedenmann J,Schenk A,Röcker C,Girod A,Spindler KD,Nienhaus GU

    更新日期:2002-09-03 00:00:00

  • Protein-tyrosine-phosphatase CD45 is phosphorylated transiently on tyrosine upon activation of Jurkat T cells.

    abstract::The leukocyte common antigen (CD45) is an abundant lymphocyte surface antigen that has been reported to be involved in signaling through the T-cell antigen receptor. CD45 is a transmembrane protein-tyrosine-phosphatase. An internal segment comprises two domains each of which is homologous to other protein-tyrosine-pho...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.17.7704

    authors: Stover DR,Charbonneau H,Tonks NK,Walsh KA

    更新日期:1991-09-01 00:00:00

  • Central nervous system activity associated with the pain evoked by bradykinin and its alteration by morphine and aspirin.

    abstract::Synthetic bradykinin, a nonapeptide formed from alpha-2 globulin in plasma, injected intra-arterially or intraperitoneally in cats in doses of 10-50 mug, evoked activity in the central nervous system in pathways associated with the signaling of pain. Similar injections of bradykinin in intact normal cats and dogs evok...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.63.3.705

    authors: Lim RK,Krauthamer G,Guzman F,Fulp RR

    更新日期:1969-07-01 00:00:00

  • Building more accurate decision trees with the additive tree.

    abstract::The expansion of machine learning to high-stakes application domains such as medicine, finance, and criminal justice, where making informed decisions requires clear understanding of the model, has increased the interest in interpretable machine learning. The widely used Classification and Regression Trees (CART) have ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1816748116

    authors: Luna JM,Gennatas ED,Ungar LH,Eaton E,Diffenderfer ES,Jensen ST,Simone CB 2nd,Friedman JH,Solberg TD,Valdes G

    更新日期:2019-10-01 00:00:00

  • Association of the lethal yellow (Ay) coat color mutation with an ecotropic murine leukemia virus genome.

    abstract::The dilute (d) coat color mutation on chromosome 9 is closely associated with an ecotropic murine leukemia virus (MuLV) genome [Jenkins, N.A., Copeland, N.G., Taylor, B.A. & Lee, B.K. (1981) Nature 293, 370-374]. DBA/2J mice homozygous for the reverse mutation to wild type at the dilute locus (d+2J) lack ecotropic vir...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.1.247

    authors: Copeland NG,Jenkins NA,Lee BK

    更新日期:1983-01-01 00:00:00

  • Dissipative structures, catastrophes, and pattern formation: a bifurcation analysis.

    abstract::A model chemical network involving reactions and diffusion is studied. Spatially and temporally ordered solutions of the equations are found by bifurcation theory. These solutions are calculated analytically and their stability is studied. Properties of these dissipative structures are discussed, and a comparison with...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.7.2748

    authors: Nicolis G,Auchmuty JF

    更新日期:1974-07-01 00:00:00

  • Anterior hypothalamic vasopressin regulates pair-bonding and drug-induced aggression in a monogamous rodent.

    abstract::After pair-bonding, male prairie voles (Microtus ochrogaster) display aggression toward novel females but not toward their female partner. Here we show that this selective aggression in pair-bonded male prairie voles is associated with increased release of vasopressin (AVP) in the anterior hypothalamus (AH). Pharmacol...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0908620106

    authors: Gobrogge KL,Liu Y,Young LJ,Wang Z

    更新日期:2009-11-10 00:00:00

  • Rlip depletion prevents spontaneous neoplasia in TP53 null mice.

    abstract::TP53 (p53) is a tumor suppressor whose functions are lost or altered in most malignancies. p53 homozygous knockout (p53-/-) mice uniformly die of spontaneous malignancy, typically T-cell lymphoma. RALBP1 (RLIP76, Rlip) is a stress-protective, mercapturic acid pathway transporter protein that also functions as a Ral ef...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1719586115

    authors: Awasthi S,Tompkins J,Singhal J,Riggs AD,Yadav S,Wu X,Singh S,Warden C,Liu Z,Wang J,Slavin TP,Weitzel JN,Yuan YC,Awasthi M,Srivastava SK,Awasthi YC,Singhal SS

    更新日期:2018-04-10 00:00:00

  • Companies' contribution to sustainability through global supply chains.

    abstract::Global supply chains play a critical role in many of the most pressing environmental stresses and social struggles identified by the United Nations' Sustainable Development Goals (SDGs). Responding to calls from the global community, companies are adopting a variety of voluntary practices to improve the environmental ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1716695115

    authors: Thorlakson T,de Zegher JF,Lambin EF

    更新日期:2018-02-27 00:00:00

  • Early onset preeclampsia in a model for human placental trophoblast.

    abstract::We describe a model for early onset preeclampsia (EOPE) that uses induced pluripotent stem cells (iPSCs) generated from umbilical cords of EOPE and control (CTL) pregnancies. These iPSCs were then converted to placental trophoblast (TB) representative of early pregnancy. Marker gene analysis indicated that both sets o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1816150116

    authors: Sheridan MA,Yang Y,Jain A,Lyons AS,Yang P,Brahmasani SR,Dai A,Tian Y,Ellersieck MR,Tuteja G,Schust DJ,Schulz LC,Ezashi T,Roberts RM

    更新日期:2019-03-05 00:00:00

  • Neural systems predicting long-term outcome in dyslexia.

    abstract::Individuals with developmental dyslexia vary in their ability to improve reading skills, but the brain basis for improvement remains largely unknown. We performed a prospective, longitudinal study over 2.5 y in children with dyslexia (n = 25) or without dyslexia (n = 20) to discover whether initial behavioral or brain...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1008950108

    authors: Hoeft F,McCandliss BD,Black JM,Gantman A,Zakerani N,Hulme C,Lyytinen H,Whitfield-Gabrieli S,Glover GH,Reiss AL,Gabrieli JD

    更新日期:2011-01-04 00:00:00

  • The Plant Homeo Domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5.

    abstract::In facultative photoperiodic flowering plants, noninductive photoperiods result in a delay in flowering, but such plants eventually flower, illustrating plasticity in an important developmental transition, flowering. The model plant, Arabidopsis, has a facultative photoperiod response. Although the inductive flowering...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1010834107

    authors: Kim DH,Sung S

    更新日期:2010-09-28 00:00:00

  • Pelizaeus-Merzbacher disease: a valine to phenylalanine point mutation in a putative extracellular loop of myelin proteolipid.

    abstract::In the central nervous system, myelin proteolipid protein isoforms (PLP and DM20) play an essential structural role in myelination. It has been shown in several species that myelination is impaired by molecular defects resulting from single base mutations in the PLP gene. We have used DNA amplification by polymerase c...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.17.7562

    authors: Pham-Dinh D,Popot JL,Boespflug-Tanguy O,Landrieu P,Deleuze JF,Boué J,Jollès P,Dautigny A

    更新日期:1991-09-01 00:00:00

  • Equivariant algebraic vector bundles over representations of reductive groups: theory.

    abstract::Let G be a reductive algebraic group and let B be an affine variety with an algebraic action of G. Everything is defined over the field C of complex numbers. Consider the trivial G-vector bundle B x S = S over B where S is a G-module. From the endomorphism ring R of the G-vector bundle S a construction of G-vector bun...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.20.9061

    authors: Masuda M,Petrie T

    更新日期:1991-10-15 00:00:00

  • Evidence for an ancient adaptive episode of convergent molecular evolution.

    abstract::Documented cases of convergent molecular evolution due to selection are fairly unusual, and examples to date have involved only a few amino acid positions. However, because convergence mimics shared ancestry and is not accommodated by current phylogenetic methods, it can strongly mislead phylogenetic inference when it...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0900233106

    authors: Castoe TA,de Koning AP,Kim HM,Gu W,Noonan BP,Naylor G,Jiang ZJ,Parkinson CL,Pollock DD

    更新日期:2009-06-02 00:00:00

  • Simple model for tuberculosis in cattle and badgers.

    abstract::As an aid to the study of bovine tuberculosis (TB), a simple model has been developed of an epidemic involving two species, cattle and badgers. Each species may infect the other. The proportion of animals affected is assumed relatively small so that the usual nonlinear aspects of epidemic theory are avoided. The model...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0509003102

    authors: Cox DR,Donnelly CA,Bourne FJ,Gettinby G,McInerney JP,Morrison WI,Woodroffe R

    更新日期:2005-12-06 00:00:00

  • ssRNA phage penetration triggers detachment of the F-pilus.

    abstract::Although the F-specific ssRNA phage MS2 has long had paradigm status, little is known about penetration of the genomic RNA (gRNA) into the cell. The phage initially binds to the F-pilus using its maturation protein (Mat), and then the Mat-bound gRNA is released from the viral capsid and somehow crosses the bacterial e...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2011901117

    authors: Harb L,Chamakura K,Khara P,Christie PJ,Young R,Zeng L

    更新日期:2020-10-13 00:00:00

  • Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis.

    abstract::Apolipoprotein L-1 (APOL1), the trypanolytic factor of human serum, can lyse several African trypanosome species including Trypanosoma brucei brucei, but not the human-infective pathogens T. brucei rhodesiense and T. brucei gambiense, which are resistant to lysis by human serum. Lysis follows the uptake of APOL1 into ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1421953112

    authors: Thomson R,Finkelstein A

    更新日期:2015-03-03 00:00:00

  • In vivo studies of fullerene-based materials using endohedral metallofullerene radiotracers.

    abstract::Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Hox@C82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Hox@C82(OH)y. This metallofullerol was then neutron-activated (165Ho[n,g...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.9.5182

    authors: Cagle DW,Kennel SJ,Mirzadeh S,Alford JM,Wilson LJ

    更新日期:1999-04-27 00:00:00

  • Selective induction of neocortical GABAergic neurons by the PDK1-Akt pathway through activation of Mash1.

    abstract::Extracellular stimuli regulate neuronal differentiation and subtype specification during brain development, although the intracellular signaling pathways that mediate these processes remain largely unclear. We now show that the PDK1-Akt pathway regulates differentiation of telencephalic neural precursor cells (NPCs). ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0808400106

    authors: Oishi K,Watatani K,Itoh Y,Okano H,Guillemot F,Nakajima K,Gotoh Y

    更新日期:2009-08-04 00:00:00

  • Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase.

    abstract::HsPKS1 from Huperzia serrata is a type III polyketide synthase (PKS) with remarkable substrate tolerance and catalytic potential. Here we present the synthesis of unnatural unique polyketide-alkaloid hybrid molecules by exploiting the enzyme reaction using precursor-directed and structure-based approaches. HsPKS1 prod...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1107782108

    authors: Morita H,Yamashita M,Shi SP,Wakimoto T,Kondo S,Kato R,Sugio S,Kohno T,Abe I

    更新日期:2011-08-16 00:00:00

  • Conserved mechanism for coordinating replication fork helicase assembly with phosphorylation of the helicase.

    abstract::Dbf4-dependent kinase (DDK) phosphorylates minichromosome maintenance 2 (Mcm2) during S phase in yeast, and Sld3 recruits cell division cycle 45 (Cdc45) to minichromosome maintenance 2-7 (Mcm2-7). We show here DDK-phosphoryled Mcm2 preferentially interacts with Cdc45 in vivo, and that Sld3 stimulates DDK phosphorylati...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1509608112

    authors: Bruck I,Kaplan DL

    更新日期:2015-09-08 00:00:00

  • Differential effects of perhydrohistrionicotoxin on neurally and iontophoretically evoked endplate currents.

    abstract::Perhydrohistrionicotoxin, at concentrations of 10(-12)-10(-7) M, depressed the current generated by iontophoretic application of acetylcholine to endplate regions of soleus and extensor digitorum longus muscles of rats. However, no changes in the amplitude or time course of spontaneous miniature endplate potentials or...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.75.3.1596

    authors: Albuquerque EX,Gage PW

    更新日期:1978-03-01 00:00:00

  • Tropomyosin synthesis accompanies formation of actin filaments in embryonal carcinoma cells induced to differentiate by hexamethylene bisacetamide.

    abstract::Hexamethylene bisacetamide (HMBA) induces in vitro the cytodifferentiation of PCC3/A/1 mouse embryonal carcinoma (EC) cells. In EC cells, actin is associated with surface structures but microfilament bundles are not seen. After 2 days of HMBA treatment, rounded EC cells are converted to flat adhesive ones with a devel...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.4.1891

    authors: Paulin D,Perreau J,Jakob H,Jacob F,Yaniv M

    更新日期:1979-04-01 00:00:00

  • Early differentiation of glucagon-producing cells in embryonic pancreas: a possible developmental role for glucagon.

    abstract::Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule cha...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.12.3478

    authors: Rall LB,Pictet RL,Williams RH,Rutter WJ

    更新日期:1973-12-01 00:00:00