Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience.

abstract：:The ability to predictably control the coassembly of multiple nanoscale building blocks, especially those with disparate chemical and physical properties such as biomolecules and inorganic nanoparticles, has far-reaching implications in catalysis, sensing, and photonics, but a generalizable strategy for engineering sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodin JD,Auyeung E,Mirkin CA

更新日期：2015-04-14 00:00:00

abstract：:The ASCAPE agent-based modeling environment greatly eases the task of designing and investigating agent-based models. However, effective design can still require a relatively deep knowledge of programming and agent-based modeling. This issue has almost certainly slowed the adoption of agent-based modeling approaches t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inchiosa ME,Parker MT

更新日期：2002-05-14 00:00:00

abstract：:We have examined the affinity of two recently synthesized flavin analogs for the isoalloxazine binding site of riboflavin-binding protein (RBP). The results showed that pyrimidopteridines could bind to RBP (Kd 160-250 microM). This suggested that, at the FMN or FAD level, these analogs might also bind to other apoflav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wessiak A,Schopfer LM,Yuan LC,Bruice TC,Massey V

更新日期：1984-07-01 00:00:00

abstract：:Effects of the anti-T-cell monoclonal antibodies OKT3, OKT5, and OKT8 on T-cell surface properties and cell functions were evaluated. Incubation of mononuclear cells isolated from peripheral blood for 48 hr with each monoclonal antibody in the absence of complement resulted in modulation of their respective surface an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Antel J,Oger JJ,Jackevicius S,Kuo HH,Arnason BG

更新日期：1982-05-01 00:00:00

abstract：:Ocular cicatricial pemphigoid (OCP) is an autoimmune disease that affects mainly conjunctiva and other squamous epithelia. OCP is histologically characterized by a separation of the epithelium from underlying tissues within the basement membrane zone. Immunopathological studies demonstrate the deposition of anti-basem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tyagi S,Bhol K,Natarajan K,Livir-Rallatos C,Foster CS,Ahmed AR

更新日期：1996-12-10 00:00:00

abstract：:We report on label-free imaging, detection, and mass/size measurement of single viral particles in solution by high-resolution surface plasmon resonance microscopy. Diffraction of propagating plasmon waves along a metal surface by the viral particles creates images of the individual particles, which allow us to detect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang S,Shan X,Patel U,Huang X,Lu J,Li J,Tao N

更新日期：2010-09-14 00:00:00

abstract：:Cofilin-actin rods are inclusion-like structures that are induced by certain chemical or physical stresses in cultured cells, and the rods formed in neurons are thought to be associated with neurodegeneration. Here, we cloned an Aplysia cofilin homolog and overexpressed it in cultured neurons. Overexpressed cofilin fo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang DH,Han JH,Lee SH,Lee YS,Park H,Lee SH,Kim H,Kaang BK

更新日期：2005-11-01 00:00:00

abstract：:Lactate racemase is the first enzyme known to possess a metal pincer active site. The enzyme interconverts d- and l-lactic acid, which is important for the assembly of cell walls in many microorganisms. Here, we report a synthetic model of the active site of lactate racemase, which features a pyridinium-based SCS pinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu T,Wodrich MD,Scopelliti R,Corminboeuf C,Hu X

更新日期：2017-02-07 00:00:00

abstract：:c-myc, N-myc, and L-myc genes are subject to highly variable degrees of tissue-specific regulation. Their aberrant expression has also been implicated in the pathogenesis of a variety of malignant tumors. The recently identified max protein dimerizes with c-myc to promote its sequence-specific DNA binding. max exists ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prochownik EV,VanAntwerp ME

更新日期：1993-02-01 00:00:00

abstract：:The formation of amyloid-like aggregates by expanded polyglutamine (polyGln) sequences is suspected to play a critical role in the neuropathology of Huntington's disease and other expanded CAG-repeat diseases. To probe the folding of the polyGln sequence in the aggregate, we replaced Gln-Gln pairs at different sequenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thakur AK,Wetzel R

更新日期：2002-12-24 00:00:00

abstract：:Noncatalytic carbohydrate binding modules (CBMs) are components of glycoside hydrolases that attack generally inaccessible substrates. CBMs mediate a two- to fivefold elevation in the activity of endo-acting enzymes, likely through increasing the concentration of the appended enzymes in the vicinity of the substrate. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cuskin F,Flint JE,Gloster TM,Morland C,Baslé A,Henrissat B,Coutinho PM,Strazzulli A,Solovyova AS,Davies GJ,Gilbert HJ

更新日期：2012-12-18 00:00:00

abstract：:The origin of the two-phase (cap, no cap) macroscopic kinetic model of the end of a microtubule is reviewed. The model is then applied to a new theoretical problem, namely, the Mitchison-Kirschner [Mitchison, T. & Kirschner, M. W. (1984) Nature (London) 312, 237-242] experiment in which aggregated microtubules in solu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Hill TL

更新日期：1985-06-01 00:00:00

abstract：:The highly ordered and reproducible structure of the fungal prion HET-s makes it an excellent model system for studying the inherent properties of prions, self-propagating infectious proteins that have been implicated in a number of fatal diseases. In particular, the HET-s prion-forming domain readily folds into a rel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan W,Stubbs G

更新日期：2014-04-08 00:00:00

abstract：:Annual reproductive success and senescence patterns vary substantially among individuals in the wild. However, it is still seldom considered that senescence may not only affect an individual but also affect age-specific reproductive success in its offspring, generating transgenerational reproductive senescence. We use...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroeger SB,Blumstein DT,Armitage KB,Reid JM,Martin JGA

更新日期：2020-03-03 00:00:00

abstract：:Expression of the bovine papillomavirus E2 regulatory protein in human cervical carcinoma cell lines repressed expression of the resident human papillomavirus E6 and E7 oncogenes and within a few days caused essentially all of the cells to synchronously display numerous phenotypic markers characteristic of cells under...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodwin EC,Yang E,Lee CJ,Lee HW,DiMaio D,Hwang ES

更新日期：2000-09-26 00:00:00

abstract：:By the use of a rapid radioautographic screening procedure, two mutants of Bacillus brevis ATCC 8185 that have lost the ability to produce gramicidin have been isolated. These mutants produced normal levels of tyrocidine and sporulated at the same frequency as the parent strain. Their spores, however, were more heat-s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mukherjee PK,Paulus H

更新日期：1977-02-01 00:00:00

abstract：:Tetherin/BST2 is a type-II membrane protein that inhibits the release of a range of enveloped viruses, including HIV-1. Here we report three crystal structures of human tetherin, including the full-length ectodomain, a triple cysteine mutant and an ectodomain truncation. These structures show that tetherin forms a con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang H,Wang J,Jia X,McNatt MW,Zang T,Pan B,Meng W,Wang HW,Bieniasz PD,Xiong Y

更新日期：2010-10-26 00:00:00

abstract：:Electrical stimulation of the cervical vagus nerve in anesthetized guinea pigs induced a rapid increase in respiratory insufflation pressure, suggesting increased airway resistance. After intravenous administration of a substance P (SP) antagonist, [D-Arg(1),D-Pro(2),D-Trp(7,9),Leu(11)]SP, the insufflation pressure re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lundberg JM,Saria A,Brodin E,Rosell S,Folkers K

更新日期：1983-02-01 00:00:00

abstract：:The nuclear envelope is a unique topological structure formed by lipid membranes in eukaryotic cells. Unlike other membrane structures, the nuclear envelope comprises two concentric membrane shells fused at numerous sites with toroid-shaped pores that impart a "geometric" genus on the order of thousands. Despite the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torbati M,Lele TP,Agrawal A

更新日期：2016-10-04 00:00:00

abstract：:H2O2, in concentrations achieved in the proximity of stimulated leukocytes, induces injury and lysis of target cells. This may be an important aspect of inflammatory injury of tissues. Cell lysis in two target cells, the murine macrophage-like tumor cell line P388D1 and human peripheral lymphocytes, was found to be as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schraufstatter IU,Hyslop PA,Hinshaw DB,Spragg RG,Sklar LA,Cochrane CG

更新日期：1986-07-01 00:00:00

abstract：:Between 1776 and 1920, the US Congress designed more than 200 distinct securities and stated the maximum amount of each that the Treasury could sell. Between 1917 and 1939, Congress gradually delegated all decisions about designing US debt instruments to the Treasury. In 1939, Congress began imposing a limit on the pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hall GJ,Sargent TJ

更新日期：2018-03-20 00:00:00

abstract：:The primary product of biological nitrogen fixation, ammonia, reversibly regulates nitrogenase activity in a variety of diazotrophs by a process called "NH4(+)-switch-off/on." Strong correlative evidence from work in Azospirillum lipoferum and Rhodospirillum rubrum indicates that this regulation involves both the inac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu H,Burris RH,Roberts GP

更新日期：1990-03-01 00:00:00

abstract：:The brain contains an astonishing diversity of neurons, each expressing only one set of ion channels out of the billions of potential channel combinations. Simple organizing principles are required for us to make sense of this abundance of possibilities and wealth of related data. We suggest that energy minimization s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hasenstaub A,Otte S,Callaway E,Sejnowski TJ

更新日期：2010-07-06 00:00:00

abstract：:Replication of severe acute respiratory syndrome (SARS) coronavirus (SARS-CoV) requires proteolytic processing of the replicase polyprotein by two viral cysteine proteases, a chymotrypsin-like protease (3CLpro) and a papain-like protease (PLpro). These proteases are important targets for development of antiviral drugs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratia K,Saikatendu KS,Santarsiero BD,Barretto N,Baker SC,Stevens RC,Mesecar AD

更新日期：2006-04-11 00:00:00

abstract：:Wnt/beta-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of Ezh2 in adi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Jin Q,Lee JE,Su IH,Ge K

更新日期：2010-04-20 00:00:00

abstract：:The environmental topology of complex structures is used by Escherichia coli to create traveling waves of high cell density, a prelude to quorum sensing. When cells are grown to a moderate density within a confining microenvironment, these traveling waves of cell density allow the cells to find and collapse into confi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Wolanin PM,Yuzbashyan EA,Lin H,Darnton NC,Stock JB,Silberzan P,Austin R

更新日期：2003-11-25 00:00:00

abstract：:Membrane lipids were once thought to be homogenously distributed in the 2D surface of a membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition away from other membrane lipids. Lipid raft theory further implicates these cholesterol-rich domains in many processes such as signaling and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Foster LJ,De Hoog CL,Mann M

更新日期：2003-05-13 00:00:00

abstract：:Molecular adaptation is typically assumed to proceed by sequential fixation of beneficial mutations. In diploids, this picture presupposes that for most adaptive mutations, the homozygotes have a higher fitness than the heterozygotes. Here, we show that contrary to this expectation, a substantial proportion of adaptiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sellis D,Callahan BJ,Petrov DA,Messer PW

更新日期：2011-12-20 00:00:00

abstract：:C.B-17 severe combined immunodeficient (scid) mice carry the scid mutation and are severely deficient in both T cell- and B cell-mediated immunity, apparently as a result of defective V(D)J joining of the immunoglobulin and T-cell receptor gene elements. In the present studies, we have defined the tissue, cellular, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biedermann KA,Sun JR,Giaccia AJ,Tosto LM,Brown JM

更新日期：1991-02-15 00:00:00

abstract：:We report an approach for the detection of magnetic resonance imaging without superconducting magnets and cryogenics: optical atomic magnetometry. This technique possesses a high sensitivity independent of the strength of the static magnetic field, extending the applicability of magnetic resonance imaging to low magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Yashchuk VV,Donaldson MH,Rochester SM,Budker D,Pines A

更新日期：2006-08-22 00:00:00