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Real-time control of the energy landscape by force directs the folding of RNA molecules.

Abstract：

:The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules can be induced into either native or misfolding pathways by modulating the relaxation rate of applied force and even be redirected during the folding process to switch from misfolding to native folding pathways. Controlling folding pathways at the single-molecule level provides a way to survey the manifold of folding trajectories and intermediates, a capability that previously was available only to theoretical studies.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Li PT,Bustamante C,Tinoco I Jr

doi

10.1073/pnas.0702137104

subject

Has Abstract

pub_date

2007-04-24 00:00:00

pages

7039-44

issue

17

eissn

0027-8424

issn

1091-6490

pii

0702137104

journal_volume

104

pub_type

杂志文章

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