Differentiation of embryonic mesenchymal cells to odontoblast-like cells by overexpression of dentin matrix protein 1.

abstract：:Examples from various plant and animal groups indicate that there has been a general increase in potential versatility of form, determined by the number and range of independently varying morphogenetic parameters, among taxa appearing at successively younger stages in the fossil record. Taxa or body plans with higher ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vermeij GJ

更新日期：1973-07-01 00:00:00

abstract：:Combinations of molecular tags visible in light and electron microscopes become particularly advantageous in the analysis of dynamic cellular components like the Golgi apparatus. This organelle disassembles at the onset of mitosis and, after a sequence of poorly understood events, reassembles after cytokinesis. The pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gaietta GM,Giepmans BN,Deerinck TJ,Smith WB,Ngan L,Llopis J,Adams SR,Tsien RY,Ellisman MH

更新日期：2006-11-21 00:00:00

abstract：:We have tried to find out why Ascaris hemoglobin has such an exceptionally high oxygen affinity (P50 approximately 0.004 mmHg; 1 mmHg = 133 Pa). Following Kloek et al., we have synthesized the N-terminal globin domain of Ascaris hemoglobin in Escherichia coli [Kloek, A. P., Yang, J., Mathews, F. S. & Goldberg, D. (199...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Perutz MF,Kiger L,Marden MC,Poyart C

更新日期：1994-02-15 00:00:00

abstract：:Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherry B,Zybarth G,Alfano M,Dubrovsky L,Mitchell R,Rich D,Ulrich P,Bucala R,Cerami A,Bukrinsky M

更新日期：1998-02-17 00:00:00

abstract：:Many materials phenomena are governed by the interaction between chemistry and mechanics. However, it was only in the second half of the 20th century that the theory of open system elasticity by Francis Larché and John W. Cahn concatenated the fields of solid mechanics and alloy chemistry. As the theory's central mate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi S,Markmann J,Weissmüller J

更新日期：2018-10-23 00:00:00

abstract：:Rett syndrome (RTT) is a severe neurodevelopmental disorder that affects about 1 in 10,000 female live births. The underlying cause of RTT is mutations in the X-linked gene, methyl-CpG-binding protein 2 (MECP2); however, the molecular mechanism by which these mutations mediate the RTT neuropathology remains enigmatic....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Osenberg S,Karten A,Sun J,Li J,Charkowick S,Felice CA,Kritzer M,Nguyen MVC,Yu P,Ballas N

更新日期：2018-06-05 00:00:00

abstract：:We have shown that a scanning transmission electron microscope with a high brightness field emission source is capable of obtaining better than 3 A resolution using 30 to 40 keV electrons. Elastic dark field images of single atoms of uranium and mercury are shown which demonstrate this fact as determined by a modified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall J,Langmore J,Isaacson M,Crewe AV

更新日期：1974-01-01 00:00:00

abstract：:We have used a microfluidic mass sensor to measure the density of single living cells. By weighing each cell in two fluids of different densities, our technique measures the single-cell mass, volume, and density of approximately 500 cells per hour with a density precision of 0.001 g mL(-1). We observe that the intrins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grover WH,Bryan AK,Diez-Silva M,Suresh S,Higgins JM,Manalis SR

更新日期：2011-07-05 00:00:00

abstract：:The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer DJ,Stephenson EW,Johnson L,Cochran BH,Schwartz J

更新日期：1993-07-15 00:00:00

abstract：:Estrogens control many physiological and behavioral processes, some of which are connected to reproduction. These include sexual and other social behaviors. Here we implicate four gene products in a micronet required for mammalian social recognition, through which an individual learns to recognize other individuals. F...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choleris E,Gustafsson JA,Korach KS,Muglia LJ,Pfaff DW,Ogawa S

更新日期：2003-05-13 00:00:00

abstract：:A fundamental aspect of climate change is the potential shifts in flowering phenology and pollen initiation associated with milder winters and warmer seasonal air temperature. Earlier floral anthesis has been suggested, in turn, to have a role in human disease by increasing time of exposure to pollen that causes aller...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ziska L,Knowlton K,Rogers C,Dalan D,Tierney N,Elder MA,Filley W,Shropshire J,Ford LB,Hedberg C,Fleetwood P,Hovanky KT,Kavanaugh T,Fulford G,Vrtis RF,Patz JA,Portnoy J,Coates F,Bielory L,Frenz D

更新日期：2011-03-08 00:00:00

abstract：:Conformational aspects of the acetylcholine receptor (AcChoR) of Electrophorus electricus have been examined by studies of its interaction with structurally related, constrained aromatic bis quaternary compounds. Among the compounds synthesized was 3,3'-bis[alpha-(trimethylammonium)-methyl]azobenzene dibromide (3,3'-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wassermann NH,Bartels E,Erlanger BF

更新日期：1979-01-01 00:00:00

abstract：:Protein-DNA interactions were studied in vivo at the region containing a human DNA replication origin, located at the 3' end of the lamin B2 gene and partially overlapping the promoter of another gene, located downstream. DNase I treatment of nuclei isolated from both exponentially growing and nonproliferating HL-60 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dimitrova DS,Giacca M,Demarchi F,Biamonti G,Riva S,Falaschi A

更新日期：1996-02-20 00:00:00

abstract：:The 2-deoxy-D-glucose method was used to study asymmetries in cerebral metabolic activity in neonatal rats. Left-right asymmetries in 2-deoxy-D-glucose uptake were observed in hippocampus, diencephalon, cortex, and medulla-pons: 2-deoxy-D-glucose incorporation was greater in right hippocampus, right diencephalon, left...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ross DA,Glick SD,Meibach RC

更新日期：1981-03-01 00:00:00

abstract：:Once-abundant aerial insectivores, such as the Tree Swallow (Tachycineta bicolor), have declined steadily in the past several decades, making it imperative to understand all aspects of their ecology. Aerial insectivores forage on a mixture of aquatic and terrestrial insects that differ in fatty acid composition, speci...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Twining CW,Brenna JT,Lawrence P,Shipley JR,Tollefson TN,Winkler DW

更新日期：2016-09-27 00:00:00

abstract：:The immunoglobulin heavy-chain-associated tetrapeptide, tuftsin (Thr-Lys-Pro-Arg), known for its phagocytosis-stimulating activity, was found to augment the antigen-specific, macrophage-dependent education of T lymphocytes. The investigation of stereospecific characteristics of the tetrapeptide, by use of structural a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tzehoval E,Segal S,Stabinsky Y,Fridkin M,Spirer Z,Feldman M

更新日期：1978-07-01 00:00:00

abstract：:The temporal dynamics of electrical activity in an olfactory organ, the procerebral lobe of the terrestrial mollusc Limax maximus, is studied. The lobe exhibits intrinsic oscillations in its field potential. Intracellular recordings show that the lobe contains two classes of neurons, both with activity phase-locked to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delaney KR,Gelperin A,Fee MS,Flores JA,Gervais R,Tank DW,Kleinfeld D

更新日期：1994-01-18 00:00:00

abstract：:Sexual arousal is a dynamical, highly coordinated neurophysiological process that is often induced by visual stimuli. Numerous studies have proposed that the cognitive processing stage of responding to sexual stimuli is the first stage, in which sex differences occur, and the divergence between men and women has been ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitricheva E,Kimura R,Logothetis NK,Noori HR

更新日期：2019-07-30 00:00:00

abstract：:Using an inducible, inflammatory model of breast cellular transformation, we describe the transcriptional regulatory network mediated by STAT3, NF-κB, and AP-1 factors on a genomic scale. These proinflammatory regulators form transcriptional complexes that directly regulate the expression of hundreds of genes in oncog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ji Z,He L,Regev A,Struhl K

更新日期：2019-05-07 00:00:00

abstract：:We have evaluated the effect of ligand binding on expression of the receptor for IgE on rat basophilic leukemia (RBL) cells. RBL cells were grown in the presence or absence of 131I-labeled IgE and sometimes were also surface labeled with 125I. We found that cells grown in the presence of IgE continued to accumulate re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi K,Rivera J,Isersky C

更新日期：1985-03-01 00:00:00

abstract：:The heme-copper oxidases constitute a superfamily of terminal dioxygen-reducing enzymes located in the inner mitochondrial or in the bacterial cell membrane. The presence of a mechanistically important covalent bond between a histidine ligand of the copper ion (Cu(B)) in the active site and a generally conserved tyros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rauhamäki V,Baumann M,Soliymani R,Puustinen A,Wikström M

更新日期：2006-10-31 00:00:00

abstract：:The electrical transport through self-assembled monolayers of alkanedithiols was studied in large-area molecular junctions and described by the Simmons model [Simmons JG (1963) J Appl Phys 34:1793-1803 and 2581-2590] for tunneling through a practical barrier, i.e., a rectangular barrier with the image potential includ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akkerman HB,Naber RC,Jongbloed B,van Hal PA,Blom PW,de Leeuw DM,de Boer B

更新日期：2007-07-03 00:00:00

abstract：:We sublocalized the yeast nucleoporin Nup82 to the cytoplasmic side of the nuclear pore complex (NPC) by immunoelectron microscopy. Moreover, by in vitro binding assays we showed that Nup82 interacts with the C-terminal region of Nup159, a yeast nucleoporin that previously was also localized to the cytoplasmic side of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurwitz ME,Strambio-de-Castillia C,Blobel G

更新日期：1998-09-15 00:00:00

abstract：:Model compositions of Earth, Venus, and Mercury are calculated from the premise that planets and chondrites underwent four identical fractionation processes in the solar nebula. Because elements of similar properties stay together in these processes, five constraints suffice to define the composition of a planet: mass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morgan JW,Anders E

更新日期：1980-12-01 00:00:00

abstract：:The programmed activation/repression of transcription factors in early hematopoietic differentiation has not yet been explored. The DNA-binding protein GATA-1 is required for normal erythroid development and regulates erythroid-expressed genes in maturing erythroblasts. We analyzed GATA-1 expression in early human adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sposi NM,Zon LI,Carè A,Valtieri M,Testa U,Gabbianelli M,Mariani G,Bottero L,Mather C,Orkin SH

更新日期：1992-07-15 00:00:00

abstract：:Despite significant infiltration into tumors and atherosclerotic plaques, the role of T lymphocytes in these pathological conditions is still unclear. We have demonstrated that tumor-infiltrating lymphocytes (TILs) and plaque-infiltrating lymphocytes (PILs) produce heparin-binding epidermal growth factor-like growth f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peoples GE,Blotnick S,Takahashi K,Freeman MR,Klagsbrun M,Eberlein TJ

更新日期：1995-07-03 00:00:00

abstract：:Receptors for platelet-derived growth factor (PDGF) have previously only been found on cells of mesenchymal and glial origin. This study shows PDGF receptors on an anaplastic thyroid carcinoma cell line, C 643, that was found to express thyroglobulin mRNA, confirming its origin from thyroid epithelium. Northern blot a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heldin NE,Gustavsson B,Claesson-Welsh L,Hammacher A,Mark J,Heldin CH,Westermark B

更新日期：1988-12-01 00:00:00

abstract：:Classical genetic selection was combined with site-directed mutagenesis to study bacteriophage T4 DNA polymerase 3'----5' exonuclease activity. A mutant DNA polymerase with very little (less than or equal to 1%) 3'----5' exonuclease activity was generated. In vivo, the 3'----5' exonuclease-deficient DNA polymerase pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reha-Krantz LJ,Stocki S,Nonay RL,Dimayuga E,Goodrich LD,Konigsberg WH,Spicer EK

更新日期：1991-03-15 00:00:00

abstract：:Histone H3 lysine 4 (H3K4) methylation is catalyzed by the highly evolutionarily conserved multiprotein complex known as Set1/COMPASS or MLL/COMPASS-like complexes from yeast to human, respectively. Here we have reconstituted fully functional yeast Set1/COMPASS and human MLL/COMPASS-like complex in vitro and have iden...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi YH,Westfield GH,Oleskie AN,Trievel RC,Shilatifard A,Skiniotis G

更新日期：2011-12-20 00:00:00

abstract：:Understanding the ecological impacts of climate change is a crucial challenge of the twenty-first century. There is a clear lack of general rules regarding the impacts of global warming on biota. Here, we present a metaanalysis of the effect of climate change on body size of ectothermic aquatic organisms (bacteria, ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daufresne M,Lengfellner K,Sommer U

更新日期：2009-08-04 00:00:00