Role of cyclophilin A in the uptake of HIV-1 by macrophages and T lymphocytes.

abstract：:Gene expression has a stochastic component because of the single-molecule nature of the gene and the small number of copies of individual DNA-binding proteins in the cell. We show how the statistics of such systems can be mapped onto quantum many-body problems. The dynamics of a single gene switch resembles the spin-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sasai M,Wolynes PG

更新日期：2003-03-04 00:00:00

abstract：:Recent analyses of high-throughput protein interaction data coupled with large-scale investigations of evolutionary properties of interaction networks have left some unanswered questions. To what extent do protein interactions act as constraints during evolution of the protein sequence? How does the type of interactio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mintseris J,Weng Z

更新日期：2005-08-02 00:00:00

abstract：:Spider-like forms of purified reovirus RNA have been characterized by electron microscopy. These structures contained 11.3 +/- 0.8 mum of double-stranded RNA and up to 20 arms, each of distinct length. Length measurements of 64 "spiders" suggest that in these structures the viral genome is folded fairly specifically. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavenoff R,Talcove D,Mudd JA

更新日期：1975-11-01 00:00:00

abstract：:Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kringelbach ML,Cruzat J,Cabral J,Knudsen GM,Carhart-Harris R,Whybrow PC,Logothetis NK,Deco G

更新日期：2020-04-28 00:00:00

abstract：:Adult rats were trained to detect the occurrence of a two-element sound sequence in a background of nine other nontarget sound pairs. Training resulted in a modest, enduring, static expansion of the cortical areas of representation of both target stimulus sounds. More importantly, once the initial stimulus A in the ta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou X,de Villers-Sidani E,Panizzutti R,Merzenich MM

更新日期：2010-08-17 00:00:00

abstract：:Synergism between transcriptional activators is a powerful way of potentiating their function. Here we show that the glial POU domain protein Tst-1 (also known as Oct-6 and SCIP) and large tumor antigen (T antigen) synergistically increased transcription from both the early and the late promoters of papovavirus JC in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Renner K,Leger H,Wegner M

更新日期：1994-07-05 00:00:00

abstract：:Allosteric regulation of oxygen delivery by RBCs may have significant effects on tumor growth. Indeed, angiogenesis, the formation of new blood vessels, is induced in growing tumors by low oxygen partial pressure. Hypoxia-inducible genes are switched on, among which are the VEGF gene and its receptors. Most important,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kieda C,Greferath R,Crola da Silva C,Fylaktakidou KC,Lehn JM,Nicolau C

更新日期：2006-10-17 00:00:00

abstract：:Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP is maintained by the trabecular meshwork (TM) and the elevation of IOP in open-angle glaucoma is associated with dysfunction and loss of the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu W,Gramlich OW,Laboissonniere L,Jain A,Sheffield VC,Trimarchi JM,Tucker BA,Kuehn MH

更新日期：2016-06-21 00:00:00

abstract：:Methicillin-resistant Staphylococcus aureus (MRSA) represents a serious threat to the health of hospitalized patients. Attempts to reduce the spread of MRSA have largely depended on hospital hygiene and patient isolation. These measures have met with mixed success: although some countries have almost eliminated MRSA o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cooper BS,Medley GF,Stone SP,Kibbler CC,Cookson BD,Roberts JA,Duckworth G,Lai R,Ebrahim S

更新日期：2004-07-06 00:00:00

abstract：:Scaling down the size of computing circuits is about to reach the limitations imposed by the discrete atomic structure of matter. Reducing the power requirements and thereby dissipation of integrated circuits is also essential. New paradigms are needed to sustain the rate of progress that society has become used to. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mol JA,Verduijn J,Levine RD,Remacle F,Rogge S

更新日期：2011-08-23 00:00:00

abstract：:TIM-4, a member of the TIM family expressed on antigen-presenting cells, binds to phosphatidylserine exposed on the surface of apoptotic bodies. However, the significance of this interaction in vivo remains unknown because other receptors have been implicated in the clearance of apoptotic bodies and could compensate f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Manzanet R,Sanjuan MA,Wu HY,Quintana FJ,Xiao S,Anderson AC,Weiner HL,Green DR,Kuchroo VK

更新日期：2010-05-11 00:00:00

abstract：:We have reported previously that murine bone marrow-derived dendritic cells (DC) pulsed with whole tumor lysates can mediate potent antitumor immune responses both in vitro and in vivo. Because successful therapy was dependent on host immune T cells, we have now evaluated whether the systemic administration of the T c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu K,Fields RC,Giedlin M,Mulé JJ

更新日期：1999-03-02 00:00:00

abstract：:A transcript generated by the distal part of the Duchenne Muscular Dystrophy (DMD) gene was initially detected in cells where the full size 14-kilobase (kb) messenger RNA is not found at a significant level. This transcript, approximately 4.5 kb long, corresponds to the cysteine-rich and carboxyl-terminal domains of d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hugnot JP,Gilgenkrantz H,Vincent N,Chafey P,Morris GE,Monaco AP,Berwald-Netter Y,Koulakoff A,Kaplan JC,Kahn A

更新日期：1992-08-15 00:00:00

abstract：:The ability of antibodies to extravasate out of blood vessels is critical for therapeutic activity, because molecular targets for most diseases are located outside of the endothelial lining. By performing detailed biodistribution studies with a novel IL9-armed cancer-specific antibody, we identified a clear correlatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Venetz D,Hess C,Lin CW,Aebi M,Neri D

更新日期：2015-02-17 00:00:00

abstract：:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal column...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumann S,Skinner K,Basbaum AI

更新日期：2005-11-15 00:00:00

abstract：:DEAD-box RNA helicase proteins use the energy of ATP hydrolysis to drive the unwinding of duplex RNA. However, the mechanism that couples ATP utilization to duplex RNA unwinding is unknown. We measured ATP utilization and duplex RNA unwinding by DbpA, a non-processive bacterial DEAD-box RNA helicase specifically activ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henn A,Cao W,Licciardello N,Heitkamp SE,Hackney DD,De La Cruz EM

更新日期：2010-03-02 00:00:00

abstract：:Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Immune cells play important roles in wound healing by following instructions from the microenvironment. Here, we developed a technology to bioengineer the wound microenvironment and enhance healing abilities of the immune...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vågesjö E,Öhnstedt E,Mortier A,Lofton H,Huss F,Proost P,Roos S,Phillipson M

更新日期：2018-02-20 00:00:00

abstract：:Eukaryotes engage in a multitude of beneficial and deleterious interactions with bacteria. Hamiltonella defensa, an endosymbiont of aphids and other sap-feeding insects, protects its aphid host from attack by parasitoid wasps. Thus H. defensa is only conditionally beneficial to hosts, unlike ancient nutritional symbio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Degnan PH,Yu Y,Sisneros N,Wing RA,Moran NA

更新日期：2009-06-02 00:00:00

abstract：:Temperate-zone species have responded to warming temperatures by shifting their distributions poleward and upslope. Thermal tolerance data suggests that tropical species may respond to warming temperatures even more strongly than temperate-zone species, but this prediction has yet to be tested. We addressed this data ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freeman BG,Class Freeman AM

更新日期：2014-03-25 00:00:00

abstract：:Tissues from rhesus monkeys were screened by PCR for the presence of sequences homologous to known adeno-associated virus (AAV) serotypes 1-6. DNA spanning entire rep-cap ORFs from two novel AAVs, called AAV7 and AAV8, were isolated. Sequence comparisons among these and previously described AAVs revealed the greatest ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao GP,Alvira MR,Wang L,Calcedo R,Johnston J,Wilson JM

更新日期：2002-09-03 00:00:00

abstract：:A comprehensive mapping of interactions among Epstein-Barr virus (EBV) proteins and interactions of EBV proteins with human proteins should provide specific hypotheses and a broad perspective on EBV strategies for replication and persistence. Interactions of EBV proteins with each other and with human proteins were as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calderwood MA,Venkatesan K,Xing L,Chase MR,Vazquez A,Holthaus AM,Ewence AE,Li N,Hirozane-Kishikawa T,Hill DE,Vidal M,Kieff E,Johannsen E

更新日期：2007-05-01 00:00:00

abstract：:The phytohormone cytokinin influences many aspects of plant growth and development, several of which also involve the cellular process of autophagy, including leaf senescence, nutrient remobilization, and developmental transitions. The Arabidopsis type-A response regulators (type-A ARR) are negative regulators of cyto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acheampong AK,Shanks C,Cheng CY,Schaller GE,Dagdas Y,Kieber JJ

更新日期：2020-10-27 00:00:00

abstract：:Several gene fusions have been constructed in which coding sequences for antigenic regions of the pre-S sequences of hepatitis B virus, hepatitis B surface antigen, and the envelope protein of human immunodeficiency virus were linked to the 3' end of that for the first 144 residues of hepatitis B core antigen. The seq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stahl SJ,Murray K

更新日期：1989-08-01 00:00:00

abstract：:Ig heavy chain (IgH) isotypes (e.g., IgM, IgG, and IgE) are generated as secreted/soluble antibodies (sIg) or as membrane-bound (mIg) B cell receptors (BCRs) through alternative RNA splicing. IgH isotype dictates soluble antibody function, but how mIg isotype influences B cell behavior is not well defined. We examined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong P,Granato A,Zuo T,Chaudhary N,Zuiani A,Han SS,Donthula R,Shrestha A,Sen D,Magee JM,Gallagher MP,van der Poel CE,Carroll MC,Wesemann DR

更新日期：2017-10-03 00:00:00

abstract：:Experimentally, protein engineering and phi-value analysis is the method of choice to characterize the structure in folding transition state ensemble (TSE) of any protein. Combining experimental phi values and computer simulations has led to a deeper understanding of how proteins fold. In this report, we construct the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Shakhnovich EI

更新日期：2001-11-06 00:00:00

abstract：:Female mosquitoes feed sequentially on carbohydrates (nectar) and proteins (blood) during each gonadotrophic cycle to become reproductively competent and effective disease vectors. Accordingly, metabolism is synchronized to support this reproductive cyclicity. However, regulatory pathways linking metabolism to reprodu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ling L,Raikhel AS

更新日期：2021-02-09 00:00:00

abstract：:During cell division, the mitotic spindle segregates the sister chromatids into two nascent cells, such that each daughter cell inherits one complete set of chromosomes. Errors in spindle formation can result in both chromosome missegregation and cytokinesis defects and hence lead to genomic instability. To ensure the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nousiainen M,Silljé HH,Sauer G,Nigg EA,Körner R

更新日期：2006-04-04 00:00:00

abstract：:Group II intron RNAs self-splice in vitro but only at high salt and/or Mg2+ concentrations and have been thought to require proteins to stabilize their active structure for efficient splicing in vivo. Here, we show that a DEAD-box protein, CYT-19, can by itself promote the splicing and reverse splicing of the yeast aI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohr S,Matsuura M,Perlman PS,Lambowitz AM

更新日期：2006-03-07 00:00:00

abstract：:A complete experimental format is given for the reconstitution of human hemoglobin from the separated heme-free alpha- and beta-globin chains (alpha degrees, beta degrees) and hemin, by two alternative routes. Based on their oxygen binding properties, the reaction of the ferri-forms with reducing agent, and the respon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yip YK,Waks M,Beychok S

更新日期：1977-01-01 00:00:00

abstract：:In this article we report an experiment that examines how demand-side bidding can discipline generators in a market for electric power. First we develop a treatment without demand-side bidding; two large firms are allocated baseload and intermediate cost generators such that either firm might unilaterally withhold the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rassenti SJ,Smith VL,Wilson BJ

更新日期：2003-03-04 00:00:00