Abstract:
:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal columns will regenerate, presumably because their intrinsic growth capacity is enhanced by the priming peripheral nerve lesion. As the effective priming lesion is made before the spinal cord injury it would clearly have no clinical utility, and unfortunately, a priming lesion made after a spinal cord injury results in an abortive regenerative response. Here, we show that two priming lesions, one made at the time of a spinal cord injury and a second 1 week after a spinal cord injury, in fact, promote dramatic regeneration, within and beyond the lesion. The first lesion, we hypothesize, enhances intrinsic growth capacity, and the second one sustains it, providing a paradigm for promoting CNS regeneration after injury.
journal_name
Proc Natl Acad Sci U S Aauthors
Neumann S,Skinner K,Basbaum AIdoi
10.1073/pnas.0508538102keywords:
subject
Has Abstractpub_date
2005-11-15 00:00:00pages
16848-52issue
46eissn
0027-8424issn
1091-6490pii
0508538102journal_volume
102pub_type
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